Autocrine Deactivation of Macrophages in Transgenic Mice Constitutively Overexpressing IL-10 Under Control of the Human CD68 Promoter
Abstract IL-10 plays an essential role in blocking cytokine production by activated macrophages. To analyze the consequences of enforced expression of IL-10 by macrophages on innate and adaptive immune responses, we generated transgenic mice (macIL-10tg mice) expressing an epitope-tagged IL-10 (Flag...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | inglese |
| Pubblicazione: |
2002
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| Accesso online: | https://doi.org/10.4049/jimmunol.168.7.3402 |
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