Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice
UBQLN2 mutations have recently been associated with familial forms of amyotrophic lateral sclerosis (ALS) and ALS-dementia. UBQLN2 encodes for ubiquilin-2, a member of the ubiquitin-like protein family which facilitates delivery of ubiquitinated proteins to the proteasome for degradation. To study t...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2015
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| 在线阅读: | https://doi.org/10.1186/s13024-015-0026-7 https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-015-0026-7 |
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