Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

UBQLN2 mutations have recently been associated with familial forms of amyotrophic lateral sclerosis (ALS) and ALS-dementia. UBQLN2 encodes for ubiquilin-2, a member of the ubiquitin-like protein family which facilitates delivery of ubiquitinated proteins to the proteasome for degradation. To study t...

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Main Authors: Carolina Ceballos‐Diaz, Awilda M. Rosario, Hyojin Park, Paramita Chakrabarty, Amanda N. Sacino, Pedro E. Cruz, Zoe Siemienski, Nicolas Lara, Corey Moran, Natalia Ravelo, Todd E. Golde, Nikolaus R. McFarland
Format: Artigo
Jezik:angleščina
Izdano: 2015
Online dostop:https://doi.org/10.1186/s13024-015-0026-7
https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-015-0026-7
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https://doi.org/10.1186/s13024-015-0026-7
https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-015-0026-7

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