Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses
T cell-to-T cell Ag presentation is increasingly attracting attention. In this study, we demonstrated that active CD4+ T (aT) cells with uptake of OVA-pulsed dendritic cell-derived exosome (EXO(OVA)) express exosomal peptide/MHC class I and costimulatory molecules. These EXO(OVA)-uptaken (targeted)...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2007
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| Online Access: | https://doi.org/10.4049/jimmunol.179.5.2731 https://journals.aai.org/jimmunol/article-pdf/179/5/2731/1247919/zim01707002731.pdf |
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