Aβ1‐42‐mediated down‐regulation of Uch‐L1 is dependent on NF‐κB activation and impaired BACE1 lysosomal degradation
Summary Amyloid‐β 1‐42 accumulation is the major pathogenetic event in Alzheimer’s disease (AD), believed to be responsible for synaptic dysfunction and neuronal cell death. However, the physiologic activity of Aβ peptides remains elusive: Aβ might not only play a toxic role, but also act as a funct...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
2012
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| ऑनलाइन पहुंच: | https://doi.org/10.1111/j.1474-9726.2012.00854.x |
| टैग: |
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