Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells.

W e report that osteopontin (OPN), a secreted, kg-Gly-Asp-containing phosphoprotein expressed at high levels in the kidney, suppresses nitric oxide (NO) synthesis induced by the inflammatory mediators y-interferon and lipopolysaccharide in primary mouse kidney proximal tubule epithelial cells.Northe...

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Main Authors: S.M. Hwang, Cecilia A. Lopez, Diane E. Heck, Carol R. Gardner, Debra L. Laskin, Jeffrey D. Laskin, David T. Denhardt
格式: Artigo
语言:英语
出版: 1994
在线阅读:https://doi.org/10.1016/s0021-9258(17)42407-0
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