Combined EGFR and Autophagy Modulation Impairs Cell Migration and Enhances Radiosensitivity in Human Glioblastoma Cells

Combined EGFR and Autophagy Modulation Impairs Cell Migration and Enhances Radiosensitivity in Human Glioblastoma Cells

Glioblastoma (GBM) remains the most aggressive and lethal brain tumor due to its molecular heterogeneity and high motility and invasion capabilities of its cells, resulting in high resistance to current standard treatments (surgery, followed by ionizing radiation combined with Temozolomide chemother...

Fuld beskrivelse

Saved in:

Bibliografiske detaljer
Main Authors:	Silvia Palumbo, Paolo Tini, Marzia Toscano, Giulia Allavena, Francesca Angeletti, Federico Manai, Clelia Miracco, Sergio Comincini, Luigi Pirtoli
Format:	Artigo
Sprog:	engelsk
Udgivet:	2014
Online adgang:	https://doi.org/10.1002/jcp.24640 https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.24640
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!

Lignende værker

microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells
af: Comincini, Sergio, et al.
Udgivet: (2013)

microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells
af: Sergio Comincini, et al.
Udgivet: (2013)

AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells
af: Fassina, L., et al.
Udgivet: (2012)

Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells
af: Giulia Barbieri, et al.
Udgivet: (2011)

Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma
af: Tini, Paolo, et al.
Udgivet: (2015)

β-catenin and Gli1 are prognostic markers in glioblastoma
af: Marco Rossi, et al.
Udgivet: (2011)

Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy
af: Tini, Paolo, et al.
Udgivet: (2017)

The prognostic role of Beclin 1 protein expression in high-grade gliomas
af: Luigi Pirtoli, et al.
Udgivet: (2009)

A Husband and a Wife with Simultaneous Presentation of Glioblastoma Multiforme: A Case Report
af: Roviello, Giandomenico, et al.
Udgivet: (2013)

Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR
af: Moritz, Stefanie, et al.
Udgivet: (2021)

The In Vitro Effects of Enzymatic Digested Gliadin on the Functionality of the Autophagy Process
af: Manai, Federico, et al.
Udgivet: (2018)

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells
af: Angeletti, Francesca, et al.
Udgivet: (2016)

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells
af: Francesca Angeletti, et al.
Udgivet: (2016)

CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy
af: Nardone, Valerio, et al.
Udgivet: (2021)

Identification of Autophagy-Related Genes and Their Regulatory miRNAs Associated with Celiac Disease in Children
af: Comincini, Sergio, et al.
Udgivet: (2017)

Biochemical Signatures of Doppel Protein in Human Astrocytomas to Support Prediction in Tumor Malignancy
af: Rognoni, Paola, et al.
Udgivet: (2010)

Extracellular vesicles in degenerative retinal diseases: A new therapeutic paradigm
af: Federico Manai, et al.
Udgivet: (2023)

Trehalose Modulates Autophagy Process to Counteract Gliadin Cytotoxicity in an In Vitro Celiac Disease Model
af: Manai, Federico, et al.
Udgivet: (2019)

Glioblastoma radiosensitization by pimozide
af: Rath, Barbara H., et al.
Udgivet: (2016)

Notch1 ablation radiosensitizes glioblastoma cells
af: Han, Na, et al.
Udgivet: (2017)

LAPTM4B knockdown increases the radiosensitivity of EGFR-overexpressing radioresistant nasopharyngeal cancer cells by inhibiting autophagy
af: Chu, Chu, et al.
Udgivet: (2019)

The Radiosensitizing Effect of AZD0530 in Glioblastoma and Glioblastoma Stem-like Cells
af: Yun, Hong Shik, et al.
Udgivet: (2021)

Autophagy and radiosensitization in cancer
af: Sharma, Khushboo, et al.
Udgivet: (2014)

Radioresistance in Glioblastoma and the Development of Radiosensitizers
af: Ali, Md Yousuf, et al.
Udgivet: (2020)

Radioresistance in Glioblastoma and the Development of Radiosensitizers
af: Md. Yousuf Ali, et al.
Udgivet: (2020)

Berberine Photo-Activation Potentiates Cytotoxicity in Human Astrocytoma Cells through Apoptosis Induction
af: Carriero, Francesca, et al.
Udgivet: (2021)

Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem‐like cells and identifies additional targets for radiosensitization
af: Barbara H. Rath, et al.
Udgivet: (2015)

Temozolomide induces autophagy in primary and established glioblastoma cells in an EGFR independent manner
af: Würstle, Silvia, et al.
Udgivet: (2017)

Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
af: Zhang, Xin, et al.
Udgivet: (2017)

Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
af: Xin Zhang, et al.
Udgivet: (2017)

LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway
af: Yang, Ji-An, et al.
Udgivet: (2015)

Development of Berberine-Loaded Nanoparticles for Astrocytoma Cells Administration and Photodynamic Therapy Stimulation
af: Sergio Comincini, et al.
Udgivet: (2023)

Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests
af: Kriegs, Malte, et al.
Udgivet: (2016)

Gene Expression Analysis of an EGFR Indirectly Related Pathway Identified PTEN and MMP9 as Reliable Diagnostic Markers for Human Glial Tumor Specimens
af: Comincini, Sergio, et al.
Udgivet: (2009)

The Combination of Metformin and Disulfiram-Cu for Effective Radiosensitization on Glioblastoma Cells
af: Rezaei, Narges, et al.
Udgivet: (2020)

A new class of radiosensitizers for glioblastoma
af: Abounader, Roger, et al.
Udgivet: (2021)

Saikosaponin-d Increases the Radiosensitivity of Hepatoma Cells by Adjusting Cell Autophagy
af: Tian, Yin-Di, et al.
Udgivet: (2019)

Radiosensitizers in the temozolomide era for newly diagnosed glioblastoma
af: Mathen, Peter, et al.
Udgivet: (2020)

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers
af: Zoi, Vasiliki, et al.
Udgivet: (2022)

Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma
af: Ruiz-Garcia, Henry, et al.
Udgivet: (2021)