Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.

The retinoblastoma gene product (Rb), a nuclear phosphoprotein, functions as a tumor suppressor that is inactivated in retinoblastoma and other malignancies. The hypophosphorylated forms of Rb are observed in the G0/G1 phase of the cell cycle, whereas the hyperphosphorylated forms predominate in S a...

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Main Authors: Richard C. Chao, Waris Khan, Y A Hannun
Formato: Artigo
Idioma:inglés
Publicado: 1992
Acceso en liña:https://doi.org/10.1016/s0021-9258(18)35858-7
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