Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
The retinoblastoma gene product (Rb), a nuclear phosphoprotein, functions as a tumor suppressor that is inactivated in retinoblastoma and other malignancies. The hypophosphorylated forms of Rb are observed in the G0/G1 phase of the cell cycle, whereas the hyperphosphorylated forms predominate in S a...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
1992
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| Online Access: | https://doi.org/10.1016/s0021-9258(18)35858-7 |
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