Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1. Comparison of the effects of native and urea-treated forms of vitronectin

Kinetic studies are presented which show that native human vitronectin, but not urea-treated vitronectin, accelerates the inactivation of human alpha-thrombin by human plasminogen activator inhibitor-1 (PAI-1). We demonstrate that although urea-treated vitronectin binds PAI-1 with an affinity greate...

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Autors principals: Michael C. Naski, Daniel A. Lawrence, Deane F. Mosher, Thomas J. Podor, David Ginsburg
Format: Artigo
Idioma:anglès
Publicat: 1993
Accés en línia:https://doi.org/10.1016/s0021-9258(18)31399-1
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