<i>In vitro</i> inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6
Aims To examine the potency of ticlopidine (TCL) as an inhibitor of cytochrome P450s (CYP450s) in vitro using human liver microsomes (HLMs) and recombinant human CYP450s. Methods Isoform‐specific substrate probes of CYP1A2, 2C19, 2C9, 2D6, 2E1 and 3A4 were incubated in HLMs or recombinant CYPs with...
שמור ב:
| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | אנגלית |
| יצא לאור: |
2000
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| גישה מקוונת: | https://doi.org/10.1046/j.1365-2125.2000.00175.x |
| תגים: |
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