Novel Path to Activation of Vascular Smooth Muscle Cells: Up-Regulation of gp130 Creates an Autocrine Activation Loop by IL-6 and Its Soluble Receptor
Abstract This study describes a novel path to the activation of smooth muscle cells (SMC) by the IL-6/soluble IL-6 receptor (sIL-6R) system. Human vascular SMC constitutively express only scant amounts of IL-6R and so do not respond to stimulation with this cytokine. We show that SMC also do not con...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| Online-Zugang: | https://doi.org/10.4049/jimmunol.163.8.4583 https://journals.aai.org/jimmunol/article-pdf/163/8/4583/1110092/im209904583p.pdf |
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