Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice
Abstract There are well-characterized age-related changes in the peripheral repertoire of CD8 T cells characterized by reductions in the ratio of naive:memory T cells and the development of large clonal expansions in the memory pool. In addition, the TCR repertoire of naive T cells is reduced with a...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | inglese |
| Pubblicazione: |
2009
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| Accesso online: | https://doi.org/10.4049/jimmunol.182.2.784 https://journals.aai.org/jimmunol/article-pdf/182/2/784/1273201/zim00209000784.pdf |
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