检索结果 - Timothy A. Lewis

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  1. 1
    Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia

    Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia 由 Timothy A. Lewis, David B. Sykes, Jason M. Law, Benito Muñoz, Joane K. Rustiguel, Maria Cristina Nonato, David T. Scadden, Stuart L. Schreiber

    出版 2016
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  2. 2
    Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

    Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress 由 Alice T. Shaw, Monte M. Winslow, Margaret Magendantz, Chensi Ouyang, James A. Dowdle, Aravind Subramanian, Timothy A. Lewis, Rebecca L. Maglathin, Nicola Tolliday, Tyler Jacks

    出版 2011
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  3. 3
    Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis

    Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis 由 Danny Hung‐Chieh Chou, Edward B. Holson, Florence F. Wagner, Alicia J. Tang, Rebecca L. Maglathlin, Timothy A. Lewis, Stuart L. Schreiber, Bridget K. Wagner

    出版 2012
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  4. 4
    Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

    Small molecules enhance autophagy and reduce toxicity in Huntington's disease models 由 Sovan Sarkar, Ethan Perlstein, Sara Imarisio, Sandra Pineau, Axelle Cordenier, Rebecca L. Maglathlin, John Webster, Timothy A. Lewis, Cahir J. O’Kane, Stuart L. Schreiber, David C. Rubinsztein

    出版 2007
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  5. 5
    Development of small-molecule probes that selectively kill cells induced to express mutant RAS

    Development of small-molecule probes that selectively kill cells induced to express mutant RAS 由 Michel Weïwer, Joshua A. Bittker, Timothy A. Lewis, Kaoru Shimada, Wan Seok Yang, Lawrence MacPherson, Sivaraman Dandapani, Michelle Palmer, Brent R. Stockwell, Stuart L. Schreiber, Benito Muñoz

    出版 2011
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  6. 6
    Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

    Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin 由 Daniel M. Fass, Rishita Shah, Balaram Ghosh, Krista M. Hennig, Stephanie Norton, Wen‐Ning Zhao, Surya A. Reis, Peter S. Klein, Ralph Mazitschek, Rebecca L. Maglathlin, Timothy A. Lewis, Stephen J. Haggarty

    出版 2010
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  7. 7
    Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

    Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells 由 Cecilia Lopez-Sambrooks, Shiteshu Shrimal, Carol Khodier, Daniel P. Flaherty, Natalie Rinis, Jonathan Charest, Ningguo Gao, Peng Zhao, Lance Wells, Timothy A. Lewis, Mark A. Lehrman, Reid Gilmore, Jennifer E. Golden, Joseph N. Contessa

    出版 2016
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  8. 8
    A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein

    A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein 由 Marius S. Pop, Nicolas Stransky, Colin W. Garvie, Jean‐Philippe Theurillat, Emily C. Hartman, Timothy A. Lewis, Cheng Zhong, Elizabeth K. Culyba, Fallon Lin, Douglas S. Daniels, Raymond Pagliarini, Lucienne Ronco, Angela N. Koehler, Levi A. Garraway

    出版 2014
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  9. 9
    Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

    Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity 由 A. Schuetz, Jinrong Min, Abdellah Allali‐Hassani, Matthieu Schapira, Michael Shuen, P. Loppnau, Ralph Mazitschek, N.P. Kwiatkowski, Timothy A. Lewis, Rebecca L. Maglathin, Thomas H. McLean, Alexey Bochkarev, A.N. Plotnikov, Masoud Vedadi, C.H. Arrowsmith

    出版 2008
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  10. 10
    Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

    Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction 由 Longqin Hu, Sadagopan Magesh, Lin Chen, Lili Wang, Timothy A. Lewis, Yu Chen, Carol Khodier, Daigo Inoyama, Lesa J. Beamer, Thomas J. Emge, Jian Shen, John E. Kerrigan, Ah‐Ng Tony Kong, Sivaraman Dandapani, Michelle Palmer, Stuart L. Schreiber, Benito Muñoz

    出版 2013
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  11. 11
    A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

    A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint 由 Marcel A.T.M. van Vugt, Alexandra K. Gardino, Rune Linding, Gerard J. Ostheimer, Hans Christian Reinhardt, Shao‐En Ong, Chris Soon Heng Tan, Hua Miao, Susan M. Keezer, Jeijin Li, Tony Pawson, Timothy A. Lewis, Steven A. Carr, Stephen J. Smerdon, Thijn R. Brummelkamp, Michael B. Yaffe

    出版 2010
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  12. 12
    Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL

    Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL 由 Raghuveer Singh Mali, Baskar Ramdas, Peilin Ma, Jianjian Shi, Veerendra Munugalavadla, Emily Sims, Lei Wei, Sasidhar Vemula, Sarah C. Nabinger, Charles B. Goodwin, Rebecca J. Chan, Fabı́ola Traina, Valeria Visconte, Ramón V. Tiu, Timothy A. Lewis, Andrew M. Stern, Qiang Wen, John D. Crispino, H. Scott Boswell, Reuben Kapur

    出版 2011
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  13. 13
    Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

    Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy 由 Jinyan Du, Paula Bernasconi, Karl R. Clauser, D.R. Mani, Stephen P. Finn, Rameen Beroukhim, Melissa Burns, Bina Julian, Xiao Peng, Haley Hieronymus, Rebecca L. Maglathlin, Timothy A. Lewis, Linda M. Liau, Phioanh L. Nghiemphu, Ingo K. Mellinghoff, David N. Louis, Massimo Loda, Steven A. Carr, Andrew L. Kung, Todd R. Golub

    出版 2008
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  14. 14
    Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

    Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics 由 Luc de Waal, Timothy A. Lewis, Matthew G. Rees, Aviad Tsherniak, Xiaoyun Wu, Peter S. Choi, Lara Gechijian, Christina R. Hartigan, Patrick W. Faloon, Mark J. Hickey, Nicola Tolliday, Steven A. Carr, Paul A. Clemons, Benito Muñoz, Bridget K. Wagner, Alykhan F. Shamji, Angela N. Koehler, Monica Schenone, Alex B. Burgin, Stuart L. Schreiber, Heidi Greulich, Matthew Meyerson

    出版 2015
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  15. 15
    Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

    Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase 由 Colin W. Garvie, Xiaoyun Wu, Malvina Papanastasiou, Sooncheol Lee, James R. Fuller, Gavin R. Schnitzler, Steven W. Horner, Andrew Baker, Terry Zhang, James Mullahoo, Lindsay Westlake, Stephanie Hoyt, Marcus Toetzl, Matthew J. Ranaghan, Luc de Waal, Joseph McGaunn, Bethany Kaplan, Federica Piccioni, Xiaoping Yang, Martin Lange, Adrian Tersteegen, D.D. Raymond, Timothy A. Lewis, Steven A. Carr, Andrew D. Cherniack, Christopher T. Lemke, Matthew Meyerson, Heidi Greulich

    出版 2021
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  16. 16
    Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

    Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia 由 David B. Sykes, Youmna Kfoury, François Mercier, Mathias J. Wawer, Jason M. Law, Mark K. Haynes, Timothy A. Lewis, Amir Schajnovitz, Esha Jain, Dongjun Lee, Hanna Meyer, Kerry A. Pierce, Nicola Tolliday, Anna Waller, Steven Ferrara, Ashley Eheim, Detlef Stoeckigt, Katrina Maxcy, Julien Cobert, Jacqueline Bachand, Brian A. Szekely, Siddhartha Mukherjee, Larry A. Sklar, Joanne Kotz, Clary B. Clish, Ruslan I. Sadreyev, Paul A. Clemons, Andreas Janzer, Stuart L. Schreiber, David T. Scadden

    出版 2016
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  17. 17
    Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

    Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription 由 Nicholas B. Struntz, Andrew Chen, Anja Deutzmann, Robert M. Wilson, Eric Stefan, Helen L. Evans, Maricela A. Ramirez, Tong Liang, Francisco Caballero, Mattheus H. E. Wildschut, Dylan V. Neel, David B. Freeman, Marius S. Pop, Marie McConkey, Sandrine Muller, Brice H. Curtin, Hanna Tseng, Kristen R. Frombach, Vincent L. Butty, Stuart S. Levine, Clémentine Féau, Sarah Elmiligy, Jiyoung A. Hong, Timothy A. Lewis, Amedeo Vetere, Paul A. Clemons, Scott Malstrom, Benjamin L. Ebert, Charles Y. Lin, Dean W. Felsher, Angela N. Koehler

    出版 2019
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  18. 18
    Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL

    Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL 由 Qiang Wen, Benjamin Goldenson, Serena J. Silver, Monica Schenone, Vlado Dančík, Zan Huang, Ling-Zhi Wang, Timothy A. Lewis, W. Frank An, Xiaoyu Li, Mark‐Anthony Bray, Clarisse Thiollier, Lauren Diebold, Laure Gilles, Martha S. Vokes, Christopher B. Moore, Meghan Bliss‐Moreau, Lynn VerPlank, Nicola Tolliday, Rama K. Mishra, Sasidhar Vemula, Jianjian Shi, Lei Wei, Reuben Kapur, Cécile K. Lopez, Bastien Gerby, Paola Ballerini, Françoise Pflumio, D. Gary Gilliland, Liat Goldberg, Yehudit Birger, Shai Izraeli, Alan S. Gamis, Franklin O. Smith, William G. Woods, Jeffrey W. Taub, Christina Scherer, James E. Bradner, Boon Cher Goh, Thomas Mercher, Anne E. Carpenter, Robert J. Gould, Paul A. Clemons, Steven A. Carr, David E. Root, Stuart L. Schreiber, Andrew M. Stern, John D. Crispino

    出版 2012
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  19. 19
    Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

    Diversity-oriented synthesis yields novel multistage antimalarial inhibitors 由 Nobutaka Kato, Eamon Comer, Tomoyo Sakata‐Kato, Arvind Sharma, Manmohan Sharma, Micah Maetani, Jessica Bastien, Nicolas M. B. Brancucci, Joshua A. Bittker, Victoria Corey, David C. Clarke, Emily R. Derbyshire, Gillian L. Dornan, Sandra Duffy, Sean Eckley, Maurice A. Itoe, Karin M. J. Koolen, Timothy A. Lewis, Ping S. Lui, Amanda K. Lukens, Emily Lund, Sandra March, Elamaran Meibalan, Bennett C. Meier, Jacob A. McPhail, Branko Mitasev, Eli L. Moss, Morgane Sayes, Yvonne Van Gessel, Mathias J. Wawer, Takashi Yoshinaga, Anne‐Marie Zeeman, Vicky M. Avery, Sangeeta N. Bhatia, John E. Burke, Flaminia Catteruccia, Jon Clardy, Paul A. Clemons, Koen J. Dechering, Jeremy R. Duvall, Michael A. Foley, Fabian Gusovsky, Clemens H. M. Kocken, Matthias Marti, Marshall Morningstar, Benito Muñoz, Daniel E. Neafsey, Amit Sharma, Elizabeth A. Winzeler, Dyann F. Wirth, Christina Scherer, Stuart L. Schreiber

    出版 2016
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