检索结果 - Thomas J. Cradick

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  1. 1
    The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

    The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells 由 Ciaran M. Lee, Thomas J. Cradick, Gang Bao

    出版 2016
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  2. 2
    CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

    CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity 由 Thomas J. Cradick, Eli J. Fine, Christopher J. Antico, Gang Bao

    出版 2013
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  3. 3
    Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

    Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing 由 Ciaran M. Lee, Thomas J. Cradick, Eli J. Fine, Gang Bao

    出版 2016
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    Revisão
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  4. 4
    An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

    An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage 由 Eli J. Fine, Thomas J. Cradick, Charles Zhao, Yanni Lin, Gang Bao

    出版 2013
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  5. 5
    COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

    COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites 由 Thomas J. Cradick, Peng Qiu, Ciaran M. Lee, Eli J. Fine, Gang Bao

    出版 2014
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  6. 6
    Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAs

    Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAs 由 Thomas J. Cradick, Kathy Keck, Shannon Bradshaw, Andrew C. Jamieson, Anton P. McCaffrey

    出版 2010
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  7. 7
    TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

    TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity 由 Claudio Mussolino, Jamal Alzubi, Eli J. Fine, Robert Morbitzer, Thomas J. Cradick, Thomas Lahaye, Gang Bao, Toni Cathomen

    出版 2014
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  8. 8
    Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

    Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome 由 Maximilian Müller, Ciaran M. Lee, Giedrius Gasiūnas, Timothy Davis, Thomas J. Cradick, Virginijus Šikšnys, Gang Bao, Toni Cathomen, Claudio Mussolino

    出版 2015
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  9. 9
    SAPTA: a new design tool for improving TALE nuclease activity

    SAPTA: a new design tool for improving TALE nuclease activity 由 Yanni Lin, Eli J. Fine, Zhilan Zheng, Christopher J. Antico, Richard A. Voit, Matthew H. Porteus, Thomas J. Cradick, Gang Bao

    出版 2014
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  10. 10
    A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood

    A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood 由 Jing Zhao, Idowu Akinsheye Akinsanmi, Dalia Arafat, Thomas J. Cradick, Ciaran M. Lee, Samridhi Banskota, Urko M. Marigorta, Gang Bao, Greg Gibson

    出版 2016
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  11. 11
    CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

    CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences 由 Yongjun Lin, Thomas J. Cradick, Matthew T. Brown, Hitesh Deshmukh, Piyush Ranjan, Neha Sarode, B.M. Wile, Paula M. Vertino, Frank J. Stewart, Gaobin Bao

    出版 2014
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  12. 12
    Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

    Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects 由 Cherie L. Ramirez, Michael T. Certo, Claudio Mussolino, Mathew J. Goodwin, Thomas J. Cradick, Anton P. McCaffrey, Toni Cathomen, Andrew M. Scharenberg, J. Keith Joung

    出版 2012
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  13. 13
    Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

    Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection 由 Lin Ye, Jiaming Wang, Ashley I. Beyer, Fernando Teque, Thomas J. Cradick, Zhongxia Qi, Judy C. Chang, Gang Bao, Marcus O. Muench, Jingwei Yu, Jay A. Levy, Yuet Wai Kan

    出版 2014
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  14. 14
    Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering

    Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering 由 Mustapha Aouida, Ayman Eid, Zahir Ali, Thomas J. Cradick, Ciaran M. Lee, Harshavardhan Deshmukh, Ahmed Atef, Dina B. AbuSamra, Samah Zeineb Gadhoum, Jasmeen S. Merzaban, Gang Bao, Magdy M. Mahfouz

    出版 2015
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  15. 15
    DNA targeting specificity of RNA-guided Cas9 nucleases

    DNA targeting specificity of RNA-guided Cas9 nucleases 由 Patrick D. Hsu, David A. Scott, Joshua A. Weinstein, F. Ann Ran, Silvana Konermann, Vineeta Agarwala, Yinqing Li, Eli J. Fine, Xuebing Wu, Ophir Shalem, Thomas J. Cradick, Luciano A. Marraffini, Gang Bao, Feng Zhang

    出版 2013
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  16. 16
    Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

    Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods 由 Hemangi G. Chaudhari, Jon Penterman, Holly Whitton, Sarah J. Spencer, Nicole Flanagan, Maria C. Lei Zhang, Elaine Huang, Aditya S. Khedkar, J. Mike Toomey, Courtney A. Shearer, Alexander W. Needham, Tony W. Ho, John D. Kulman, Thomas J. Cradick, Andrew Kernytsky

    出版 2020
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  17. 17
    Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus

    Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus 由 Chiara Antoniani, Vasco Meneghini, Annalisa Lattanzi, Tristan Félix, Oriana Romano, Elisa Magrin, Leslie Weber, Giulia Pavani, Sara El Hoss, Ryo Kurita, Yukio Nakamura, Thomas J. Cradick, Ante S. Lundberg, Matthew H. Porteus, Mario Amendola, Wassim El Nemer, Marina Cavazzana, Fulvio Mavilio, Annarita Miccio

    出版 2018
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  18. 18
    Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates

    Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates 由 Tricia H. Burdo, Chen Chen, Rafal Kaminski, Ilker K. Sariyer, Pietro Mancuso, Martina Donadoni, Mandy D. Smith, Rahsan Sariyer, Maurizio Caocci, Shuren Liao, Hong Liu, Wenwen Huo, Huaqing Zhao, John Misamore, Mark G. Lewis, Vahan Simonyan, Elaine E. Thompson, Ethan Xu, Thomas J. Cradick, Jennifer Gordon, Kamel Khalili

    出版 2023
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  19. 19
    TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

    TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs 由 Shingo Suzuki, R. Geoffrey Sargent, Beate Illek, Horst Fischer, Alaleh Esmaeili‐Shandiz, M J Yezzi, Albert Lee, Yanu Yang, Soya Kim, Peter F. Renz, Zhongxia Qi, Jingwei Yu, Marcus O. Muench, Ashley I. Beyer, Alessander Guimaraes, Lin Ye, Judy C. Chang, Eli J. Fine, Thomas J. Cradick, Gang Bao, Meghdad Rahdar, Matthew H. Porteus, Tsuyoshi Shuto, Hirofumi Kai, Yuet Wai Kan, Dieter C. Gruenert

    出版 2016
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