Výsledky vyhledávání - Steven G. Younkin

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  1. 1
    Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

    Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein Autor Fangyi Zhang, Chris Eckman, Steven G. Younkin, Karen Hsiao, Costantino Iadecola

    Vydáno 1997
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  2. 2
    In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

    In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Autor Mark L. Cohen, Todd E. Golde, M. Usiak, Linda H. Younkin, Steven G. Younkin

    Vydáno 1988
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  3. 3
    Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

    Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease Autor Takeshi Kawarabayashi, Linda H. Younkin, Takaomi C. Saido, Mikio Shoji, Karen H. Ashe, Steven G. Younkin

    Vydáno 2001
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  4. 4
    Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation

    Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation Autor Raymond Scott Turner, Nobuhiro Suzuki, Abraham S.C. Chyung, Steven G. Younkin, Virginia M.‐Y. Lee

    Vydáno 1996
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  5. 5
    NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide

    NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide Autor Laibaik Park, Josef Anrather, Ping Zhou, Kelly Frys, Rose Pitstick, Steven G. Younkin, George A. Carlson, Costantino Iadecola

    Vydáno 2005
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  6. 6
    The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

    The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Autor Mark R. Palmert, Marcia B. Podlisny, D. S. Witker, Tilman Oltersdorf, Linda H. Younkin, Dennis J. Selkoe, Steven G. Younkin

    Vydáno 1989
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  7. 7
    Differences in the A?40/A?42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

    Differences in the A?40/A?42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype Autor Anne M. Fagan, Linda H. Younkin, John C. Morris, John Denis Fryer, Thomas Cole, Steven G. Younkin, David M. Holtzman

    Vydáno 2000
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  8. 8
    Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

    Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain Autor Stephen A. Gravina, Libin Ho, Christopher B. Eckman, Kristin E. Long, László Ötvös, Linda H. Younkin, Nobuhiro Suzuki, Steven G. Younkin

    Vydáno 1995
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  9. 9
    Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

    Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease Autor Linda Kotilinek, Brian J. Bacskai, Marcus A. Westerman, Takeshi Kawarabayashi, Linda H. Younkin, Bradley T. Hyman, Steven G. Younkin, Karen H. Ashe

    Vydáno 2002
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  10. 10
    BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

    BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease Autor Masuo Ohno, Evgeny A. Sametsky, Linda H. Younkin, Holly D. Oakley, Steven G. Younkin, Martin Citron, Robert Vassar, John F. Disterhoft

    Vydáno 2004
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  11. 11
    Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

    Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Autor Andrew M. Wertkin, Raymond Scott Turner, Samuel J. Pleasure, Todd E. Golde, Steven G. Younkin, John Q. Trojanowski, V M Lee

    Vydáno 1993
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  12. 12
    Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

    Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains Autor Li Ma, Mariet Allen, Nobutaka Sakae, Nilüfer Ertekin‐Taner, Neill R. Graff‐Radford, Dennis W. Dickson, Steven G. Younkin, Daniel Sevlever

    Vydáno 2016
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  13. 13
    An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

    An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos Autor Janine A Davis, Satoshi Naruse, Hua Chen, Chris Eckman, Steven G. Younkin, Donald L. Price, David Borchelt, Sangram S. Sisodia, Philip C. Wong

    Vydáno 1998
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  14. 14
    Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice

    Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice Autor Joanna L. Jankowsky, Linda H. Younkin, Victoria Gonzales, Daniel J. Fadale, Hilda H. Slunt, Henry A. Lester, Steven G. Younkin, David Borchelt

    Vydáno 2007
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  15. 15
    Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

    Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation Autor Kiyoshi Niwa, Linda H. Younkin, Christine Ebeling, Sherry Turner, David Westaway, Steven G. Younkin, Karen H. Ashe, George A. Carlson, Costantino Iadecola

    Vydáno 2000
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  16. 16
    Genetic variants in a haplotype block spanningIDE are significantly associated with plasma A?42 levels and risk for Alzheimer disease

    Genetic variants in a haplotype block spanningIDE are significantly associated with plasma A?42 levels and risk for Alzheimer disease Autor Nil�fer Ertekin-Taner, Mariet Allen, Daniel J. Fadale, Leah Scanlin, Linda H. Younkin, Ronald C. Petersen, Neill R. Graff‐Radford, Steven G. Younkin

    Vydáno 2004
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  17. 17
    The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

    The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease Autor Marcus A. Westerman, Deirdre Cooper-Blacketer, Ami Mariash, Linda Kotilinek, Takeshi Kawarabayashi, Linda H. Younkin, George A. Carlson, Steven G. Younkin, Karen H. Ashe

    Vydáno 2002
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  18. 18
    APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

    APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes Autor Jing Zhao, Mary Dabney Davis, Yuka A. Martens, Mitsuru Shinohara, Neill R. Graff‐Radford, Steven G. Younkin, Zbigniew K. Wszołek, Takahisa Kanekiyo, Guojun Bu

    Vydáno 2017
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  19. 19
    Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

    Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease Autor Joanna L. Jankowsky, Tatiana Melnikova, Daniel J. Fadale, Guilian Xu, Hilda H. Slunt, Victoria Gonzales, Linda H. Younkin, Steven G. Younkin, David Borchelt, Alena Savonenko

    Vydáno 2005
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  20. 20
    Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and<i>Drosophila</i>Genetic Models of Epilepsy

    Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and<i>Drosophila</i>Genetic Models of Epilepsy Autor Jerrah K. Holth, Valerie C. Bomben, John G. Reed, Taeko Inoue, Linda H. Younkin, Steven G. Younkin, Robia G. Pautler, Juan Botas, Jeffrey L. Noebels

    Vydáno 2013
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