Search Results - Srivatsan Raghavan

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  1. 1
    Cell polarity triggered by cell-cell adhesion via E-cadherin

    Cell polarity triggered by cell-cell adhesion via E-cadherin by Ravi A. Desai, Lin Gao, Srivatsan Raghavan, Wendy F. Liu, Christopher S. Chen

    Published 2009
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  2. 2
    An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling

    An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling by Dana M. Pirone, Wendy F. Liu, Sami Alom Ruiz, Lin Gao, Srivatsan Raghavan, Christopher A. Lemmon, Lewis H. Romer, Christopher S. Chen

    Published 2006
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  3. 3
    Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes

    Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes by Piyush Jain, Justin H. Lo, Santosh R. Rananaware, Marco A. Downing, Apekshya Panda, Michelle Tai, Srivatsan Raghavan, Heather E. Fleming, Sangeeta N. Bhatia

    Published 2019
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  4. 4
    Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma

    Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma by James M. Cleary, Betty Rouaisnel, Antoine Daina, Srivatsan Raghavan, Lauren A. Roller, Brandon M. Huffman, Harshabad Singh, Patrick Y. Wen, Nabeel Bardeesy, Vincent Zoete, Brian M. Wolpin, Julie-Aurore Losman

    Published 2022
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  5. 5
    iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer

    iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer by Justin H. Lo, Liangliang Hao, Mandar D. Muzumdar, Srivatsan Raghavan, Ester J. Kwon, Emilia M. Pulver, Felicia Hsu, Andrew J. Aguirre, Brian M. Wolpin, Charles S. Fuchs, William C. Hahn, Tyler Jacks, Sangeeta N. Bhatia

    Published 2018
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  6. 6
    RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition

    RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition by Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicińska, Kimmie Ng, Marios Giannakis

    Published 2022
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  7. 7
    Transforming Growth Factor-β Blockade in Pancreatic Cancer Enhances Sensitivity to Combination Chemotherapy

    Transforming Growth Factor-β Blockade in Pancreatic Cancer Enhances Sensitivity to Combination Chemotherapy by Qiang Li, Megan T. Hoffman, Lestat R. Ali, Jaime I. Castillo, Lauren Kageler, Ayantu Temesgen, Patrick J. Lenehan, S. Jennifer Wang, Elisa Bello, Victoire Cardot‐Ruffino, Giselle A. Uribe, Annan Yang, Michael Dougan, Andrew J. Aguirre, Srivatsan Raghavan, Marc R. Pelletier, Viviana Cremasco, Stephanie K. Dougan

    Published 2023
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  8. 8
    KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

    KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer by Elsa Krall, Belinda Wang, Diana M. Muñoz, Nina Ilić, Srivatsan Raghavan, Matthew J. Niederst, Kristine Yu, David A. Ruddy, Andrew J. Aguirre, Jong Wook Kim, Amanda J. Redig, Justin F. Gainor, Juliet Williams, John M. Asara, John G. Doench, Pasi A. Jänne, Alice T. Shaw, Robert McDonald, Jeffrey A. Engelman, Frank Stegmeier, Michael R. Schlabach, William C. Hahn

    Published 2017
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  9. 9
    Scalable, compressed phenotypic screening using pooled perturbations

    Scalable, compressed phenotypic screening using pooled perturbations by Nuo Liu, Walaa E. Kattan, Benjamin E. Mead, Conner Kummerlowe, Thomas W. Cheng, Sarah Ingabire, Jaime H. Cheah, Christian K. Soule, Anita Vrcic, Jane K. McIninch, Sergio Triana, Manuel Guzmán, Tyler T. Dao, Joshua M. Peters, Kristen E. Lowder, Lorin Crawford, Ava P. Amini, Paul C. Blainey, William C. Hahn, Brian Cleary, Bryan D. Bryson, Peter Winter, Srivatsan Raghavan, Alex K. Shalek

    Published 2024
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  10. 10
    SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO

    SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO by Patrícia Cristine Borck, Isabella Boyle, Kristina Janković, Nolan Bick, Kyla Foster, Anthony C. Lau, Lucy Parker-Burns, Daniel A. Lubicki, Tianxia Li, Ashir A. Borah, Nicholas J. Lofaso, Sohani Das Sharma, Timothy A. Chan, Riya V. Kishen, Anisah Adeagbo, Srivatsan Raghavan, Elisa Aquilanti, John R. Prensner, John M. Krill-Burger, Todd R. Golub, Catarina D. Campbell, Joshua M. Dempster, Edmond M. Chan, Francisca Vázquez

    Published 2025
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  11. 11
    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers by Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, Emma Pailler, Timothy L. Bosse, Maneesha Thaker, Diego Almanza, Joshua M. Dempster, Joshua Pan, Federica Piccioni, Nancy Dumont, Alfredo González, Jonathan Rennhack, Behnam Nabet, John A. Bachman, Amy Goodale, Yenarae Lee, Mukta Bagul, Rosy Liao, Adrija J. Navarro, Tina L. Yuan, Raymond W.S. Ng, Srivatsan Raghavan, Nathanael S. Gray, Aviad Tsherniak, Francisca Vázquez, David E. Root, Ari Firestone, Jeff Settleman, William C. Hahn, Andrew J. Aguirre

    Published 2019
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  12. 12
    Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer

    Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer by Harshabad Singh, Rachel B. Keller, Kevin S. Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Elizabeth F. Cohen, Michael Tolstorukov, Elizabeth Andrews, Lauren K. Brais, Annacarolina da Silva, Kimberly Perez, Douglas A. Rubinson, Rishi Surana, Marios Giannakis, Kimmie Ng, Thomas E. Clancy, Matthew B. Yurgelun, Benjamin L. Schlechter, Jeffrey W. Clark, Geoffrey I. Shapiro, Michael H. Rosenthal, Jason L. Hornick, Valentina Nardi, Yvonne Li, Hersh Gupta, Andrew D. Cherniack, Matthew Meyerson, James M. Cleary, Jonathan A. Nowak, Brian M. Wolpin, Andrew J. Aguirre

    Published 2023
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  13. 13
    Discovery of a selective inhibitor of doublecortin like kinase 1

    Discovery of a selective inhibitor of doublecortin like kinase 1 by Fleur M. Ferguson, Behnam Nabet, Srivatsan Raghavan, Yan Liu, Alan L. Leggett, Miljan Kuljanin, Radha L. Kalekar, Annan Yang, Shuning He, Jinhua Wang, Raymond W.S. Ng, Rita Sulahian, Lianbo Li, Emily J. Poulin, Ling Huang, Jošt Vrabič Koren, Nora Diéguez-Martínez, Sergio Espinosa-Gil, Zhiyang Zeng, Cesear Corona, James D. Vasta, Ryoma Ohi, Taebo Sim, Nam Doo Kim, Wayne Harshbarger, José M. Lizcano, Matthew B. Robers, Senthil Muthaswamy, Charles Y. Lin, A. Thomas Look, Kevin M. Haigis, Joseph D. Mancias, Brian M. Wolpin, Andrew J. Aguirre, William C. Hahn, Kenneth D. Westover, Nathanael S. Gray

    Published 2020
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  14. 14
    WRN helicase is a synthetic lethal target in microsatellite unstable cancers

    WRN helicase is a synthetic lethal target in microsatellite unstable cancers by Edmond M. Chan, Tsukasa Shibue, James M. McFarland, Benjamin Gaeta, Mahmoud Ghandi, Nancy Dumont, Alfredo González, Justine S. McPartlan, Tianxia Li, Yanxi Zhang, Jie Bin Liu, Jean‐Bernard Lazaro, Peili Gu, Cortt G. Piett, Annie Apffel, Syed O. Ali, Rebecca Deasy, Paula Keskula, Raymond W.S. Ng, Emma A. Roberts, Elizaveta Reznichenko, Lisa Leung, Maria Alimova, Monica Schenone, Mirazul Islam, Yosef E. Maruvka, Yang Liu, Jatin Roper, Srivatsan Raghavan, Marios Giannakis, Yuen‐Yi Tseng, Zachary D. Nagel, Alan D. D’Andrea, David E. Root, Jesse S. Boehm, Gad Getz, Sandy Chang, Todd R. Golub, Aviad Tsherniak, Francisca Vázquez, Adam J. Bass

    Published 2019
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  15. 15
    <i>FGFR2</i>Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma

    <i>FGFR2</i>Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma by James M. Cleary, Srivatsan Raghavan, Qibiao Wu, Yvonne Y. Li, Liam F. Spurr, Hersh Gupta, Douglas A. Rubinson, Isobel J. Fetter, Jason L. Hornick, Jonathan A. Nowak, Giulia Siravegna, Lipika Goyal, Lei Shi, Lauren K. Brais, Maureen Loftus, Atul B. Shinagare, Thomas A. Abrams, Thomas E. Clancy, Jiping Wang, Anuj Patel, Franck Brichory, Anne Vaslin Chessex, Ryan J. Sullivan, Rachel B. Keller, Sarah Denning, Emma R. Hill, Geoffrey I. Shapiro, Anna Pokorska-Bocci, Claudio Zanna, Kimmie Ng, Deborah Schrag, Pasi A. Jänne, William C. Hahn, Andrew D. Cherniack, Ryan B. Corcoran, Matthew Meyerson, Antoine Daina, Vincent Zoete, Nabeel Bardeesy, Brian M. Wolpin

    Published 2021
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  16. 16
    TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma

    TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma by Lipika Goyal, Lei Shi, Leah Y. Liu, Ferran Fece de la Cruz, Jochen K. Lennerz, Srivatsan Raghavan, Ignaty Leschiner, Liudmila Elagina, Giulia Siravegna, Raymond W.S. Ng, Phuong Vu, Krushna C. Patra, Supriya K. Saha, Raul N. Uppot, Ron Arellano, Stephanie Reyes, Takeshi Sagara, Sachie Otsuki, Brandon Nadres, Heather A. Shahzade, Ipsita Dey‐Guha, Isobel J. Fetter, Islam Baiev, Emily E. Van Seventer, Janet E. Murphy, Cristina R. Ferrone, Kenneth K. Tanabe, Vikram Deshpande, James J. Harding, Rona Yaeger, Robin Kate Kelley, Alberto Bardelli, A. John Iafrate, William C. Hahn, Cyril H. Benes, David T. Ting, Hiroshi Hirai, Gad Getz, Dejan Juric, Andrew X. Zhu, Ryan B. Corcoran, Nabeel Bardeesy

    Published 2019
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  17. 17
    Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

    Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity by Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin

    Published 2022
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  18. 18
    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer by Luisa F. Escobar‐Hoyos, Alex Penson, Ram Kannan, Hana Cho, Chun‐Hao Pan, Rohit K. Singh, Lisa Helene Apken, G. Aaron Hobbs, Renhe Luo, Nicolas Lecomte, Sruthi Babu, Fong Cheng Pan, Direna Alonso‐Curbelo, John P. Morris, Gökçe Aşkan, Olivera Grbovic-Huezo, Paul Ogrodowski, Jonathan Bermeo, Joseph A. Saglimbeni, Cristian D. Cruz, Yu-Jui Ho, Sharon Lawrence, Jerry P. Melchor, Grant A. Goda, Karen Bai, Alessandro Pastore, Simon J. Hogg, Srivatsan Raghavan, Peter J. Bailey, David K. Chang, Andrew V. Biankin, Kenneth R. Shroyer, Brian M. Wolpin, Andrew J. Aguirre, Andrea Ventura, Barry S. Taylor, Channing J. Der, Daniel Domínguez, Daniel Kümmel, Andrea Oeckinghaus, Scott W. Lowe, Robert K. Bradley, Omar Abdel‐Wahab, Steven D. Leach

    Published 2020
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  19. 19
    Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

    Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer by Srivatsan Raghavan, Peter Winter, Andrew W. Navia, Hannah L. Williams, Alan DenAdel, Kristen E. Lowder, Jennyfer Galvez-Reyes, Radha L. Kalekar, Nolawit Mulugeta, Kevin S. Kapner, Manisha Raghavan, Ashir A. Borah, Nuo Liu, Sara A. Väyrynen, Andressa Dias Costa, Raymond W.S. Ng, Junning Wang, Emma K. Hill, Dorisanne Ragon, Lauren K. Brais, Alex M. Jaeger, Liam F. Spurr, Yvonne Y. Li, Andrew D. Cherniack, Matthew A. Booker, Elizabeth F. Cohen, Michael Tolstorukov, Isaac Wakiro, Asaf Rotem, Bruce E. Johnson, James M. McFarland, Ewa Sicińska, Tyler Jacks, Ryan J. Sullivan, Geoffrey I. Shapiro, Thomas E. Clancy, Kimberly Perez, Douglas A. Rubinson, Kimmie Ng, James M. Cleary, Lorin Crawford, Scott R. Manalis, Jonathan A. Nowak, Brian M. Wolpin, William C. Hahn, Andrew J. Aguirre, Alex K. Shalek

    Published 2021
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  20. 20
    Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

    Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine by Andrew J. Aguirre, Jonathan A. Nowak, Nicholas D. Camarda, Richard A. Moffitt, Arezou A. Ghazani, Mehlika Hazar-Rethinam, Srivatsan Raghavan, Jaegil Kim, Lauren K. Brais, Dorisanne Ragon, Marisa W. Welch, Emma Reilly, Devin McCabe, Lori Marini, Kristin Anderka, Karla Helvie, Nelly Oliver, Ana Babić, Annacarolina da Silva, Brandon Nadres, Emily E. Van Seventer, Heather A. Shahzade, Joseph P. St. Pierre, Kelly P. Burke, Thomas E. Clancy, James M. Cleary, Leona A. Doyle, Kunal Jajoo, Nadine J. McCleary, Jeffrey A. Meyerhardt, Janet E. Murphy, Kimmie Ng, Anuj Patel, Kimberly Perez, Michael H. Rosenthal, Douglas A. Rubinson, Marvin Ryou, Geoffrey I. Shapiro, Ewa Sicińska, Stuart G. Silverman, Rebecca J. Nagy, Richard B. Lanman, Deborah Knoerzer, Dean J. Welsch, Matthew B. Yurgelun, Charles S. Fuchs, Levi A. Garraway, Gad Getz, Jason L. Hornick, Bruce E. Johnson, Matthew H. Kulke, Robert J. Mayer, Jeffrey W. Miller, Paul B. Shyn, David A. Tuveson, Nikhil Wagle, Jen Jen Yeh, William C. Hahn, Ryan B. Corcoran, Scott L. Carter, Brian M. Wolpin

    Published 2018
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