Search Results - Simon Crumpler

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  1. 1
    Structural Basis of Poly(ADP-ribose) Recognition by the Multizinc Binding Domain of Checkpoint with Forkhead-associated and RING Domains (CHFR)

    Structural Basis of Poly(ADP-ribose) Recognition by the Multizinc Binding Domain of Checkpoint with Forkhead-associated and RING Domains (CHFR) by Jasmeen Oberoi, Mark W. Richards, Simon Crumpler, Nathan J. Brown, Julian Blagg, Richard Bayliss

    Published 2010
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  2. 2
    Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-<i>b</i>]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

    Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-<i>b</i>]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells by Vassilios Bavetsias, Amir Faisal, Simon Crumpler, Nathan J. Brown, Magda Kosmopoulou, Amar Joshi, Butrus Atrash, Yolanda Pérez-Fuertes, Jessica Schmitt, K. Boxall, Rosemary Burke, Chongbo Sun, Sian Avery, Katherine Bush, Alan T. Henley, Florence I. Raynaud, Paul Workman, Richard Bayliss, Spiros Linardopoulos, Julian Blagg

    Published 2013
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  3. 3
    Optimization of Imidazo[4,5-<i>b</i>]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

    Optimization of Imidazo[4,5-<i>b</i>]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candi... by Vassilios Bavetsias, Simon Crumpler, Chongbo Sun, Sian Avery, Butrus Atrash, Amir Faisal, Andrew S. Moore, Magda Kosmopoulou, Nathan J. Brown, Peter Sheldrake, Katherine Bush, Alan T. Henley, Gary Box, Melanie Valenti, Alexis de Haven Brandon, Florence I. Raynaud, Paul Workman, Suzanne A. Eccles, Richard Bayliss, Spiros Linardopoulos, Julian Blagg

    Published 2012
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  4. 4
    Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

    Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19 by Aurélie Mallinger, Kai Schiemann, Christian Rink, Frank Stieber, Michel Calderini, Simon Crumpler, Mark Stubbs, Olajumoke Adeniji-Popoola, Oliver Poeschke, Michael Busch, Paul Czodrowski, Djordje Müsil, Dániel Schwarz, Maria-Jesus Ortiz-Ruiz, Richard Schneider, Ching Thai, Melanie Valenti, Alexis de Haven Brandon, Rosemary Burke, Paul Workman, Trevor Dale, Dirk Wienke, Paul A. Clarke, Christina Esdar, Florence I. Raynaud, Suzanne A. Eccles, Felix Rohdich, Julian Blagg

    Published 2016
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  5. 5
    Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

    Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen by Aurélie Mallinger, Simon Crumpler, Mark Pichowicz, Dennis Waalboer, Mark Stubbs, Olajumoke Adeniji-Popoola, Bozena Wood, Elizabeth Smith, Ching Thai, Alan T. Henley, Katrin Georgi, William Court, Steve Hobbs, Gary Box, Maria-Jesus Ortiz-Ruiz, Melanie Valenti, Alexis de Haven Brandon, Robert te Poele, Birgitta Leuthner, Paul Workman, Wynne Aherne, Oliver Poeschke, Trevor Dale, Dirk Wienke, Christina Esdar, Felix Rohdich, Florence I. Raynaud, Paul A. Clarke, Suzanne A. Eccles, Frank Stieber, Kai Schiemann, Julian Blagg

    Published 2015
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