Resultats de la cerca - Sherif F. El‐Khamisy

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  1. 1
    A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

    A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage per Sherif F. El‐Khamisy

    Publicat 2003
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  2. 2
    TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

    TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy per Meryem Alagöz, Owen S. Wells, Sherif F. El‐Khamisy

    Publicat 2013
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  3. 3
    Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets

    Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets per Duncan C. Gilbert, Anthony J. Chalmers, Sherif F. El‐Khamisy

    Publicat 2011
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  4. 4
    ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

    ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells per Meryem Alagöz, Shih‐Chieh Chiang, Abhishek Bharadwaj Sharma, Sherif F. El‐Khamisy

    Publicat 2013
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  5. 5
    APLF (C2orf13) Is a Novel Human Protein Involved in the Cellular Response to Chromosomal DNA Strand Breaks

    APLF (C2orf13) Is a Novel Human Protein Involved in the Cellular Response to Chromosomal DNA Strand Breaks per Natasha Iles, Stuart L. Rulten, Sherif F. El‐Khamisy, Keith W. Caldecott

    Publicat 2007
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  6. 6
    TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

    TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage per Zhihong Zeng, Felipe Cortés‐Ledesma, Sherif F. El‐Khamisy, Keith W. Caldecott

    Publicat 2010
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  7. 7
    Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites

    Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites per Н. А. Лебедева, Н. И. Речкунова, Sherif F. El‐Khamisy, Olga I. Lavrik

    Publicat 2012
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  8. 8
    SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

    SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair per Jessica J. R. Hudson, Shih‐Chieh Chiang, Owen S. Wells, Chris Rookyard, Sherif F. El‐Khamisy

    Publicat 2012
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  9. 9
    DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity

    DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity per Jannigje Rachel Kok, Nelma M. Palminha, Cleide Dos Santos Souza, Sherif F. El‐Khamisy, Laura Ferraiuolo

    Publicat 2021
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  10. 10
    Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

    Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin per Sherif F. El‐Khamisy, Sachin Katyal, Poorvi Patel, Limei Ju, Peter J. McKinnon, Keith W. Caldecott

    Publicat 2009
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  11. 11
    Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

    Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection per Angela EM Ibler, Mohamed ElGhazaly, Kathryn Naylor, Natalia A. Bulgakova, Sherif F. El‐Khamisy, Daniel Humphreys

    Publicat 2019
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  12. 12
    DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms

    DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms per Arwa A. Abugable, Julia L.M. Morris, Nelma M. Palminha, Ringaile Zaksauskaite, Swagat Ray, Sherif F. El‐Khamisy

    Publicat 2019
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  13. 13
    Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan

    Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan per Cornelia Meisenberg, Duncan C. Gilbert, Anthony J. Chalmers, Vikki Haley, Simon Gollins, Simon E. Ward, Sherif F. El‐Khamisy

    Publicat 2014
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  14. 14
    Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage

    Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage per Shih‐Chieh Chiang, Martin Meagher, Nick Kassouf, Majid Hafezparast, Peter J. McKinnon, Rachel Haywood, Sherif F. El‐Khamisy

    Publicat 2017
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  15. 15
    TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

    TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo per Sachin Katyal, Sherif F. El‐Khamisy, H. R. Russell, Yang Li, Limei Ju, Keith W. Caldecott, Peter J. McKinnon

    Publicat 2007
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  16. 16
    The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1

    The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1 per Youngsoo Lee, Sachin Katyal, Yang Li, Sherif F. El‐Khamisy, H. R. Russell, Keith W. Caldecott, Peter J. McKinnon

    Publicat 2009
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  17. 17
    The Protein Kinase CK2 Facilitates Repair of Chromosomal DNA Single-Strand Breaks

    The Protein Kinase CK2 Facilitates Repair of Chromosomal DNA Single-Strand Breaks per Joanna I. Loizou, Sherif F. El‐Khamisy, Anastasia Zlatanou, David Moore, Douglas W. Chan, Jun Qin, Stefania Sarno, Flavio Meggio, Lorenzo A. Pinna, Keith W. Caldecott

    Publicat 2004
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  18. 18
    TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

    TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 per Zhihong Zeng, Abhishek Bharadwaj Sharma, Limei Ju, Junko Murai, Lieve Umans, Liesbeth Vermeire, Yves Pommier, Shunichi Takeda, Danny Huylebroeck, Keith W. Caldecott, Sherif F. El‐Khamisy

    Publicat 2012
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  19. 19
    Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks

    Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks per Claudia Kerzendorfer, Annabel Whibley, Gillian Carpenter, Emily Outwin, Shih‐Chieh Chiang, Gillian Turner, Charles E. Schwartz, Sherif F. El‐Khamisy, F. Lucy Raymond, Mark O’Driscoll

    Publicat 2010
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  20. 20
    Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan

    Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan per Cornelia Meisenberg, Mohamed E. Ashour, Lamia El-Shafie, Chunyan Liao, Adam Hodgson, Alice Elizabeth Pilborough, Syed Ali Khurram, Jessica A. Downs, Simon E. Ward, Sherif F. El‐Khamisy

    Publicat 2016
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