Resultats de la cerca - Sahil Seth

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  1. 1
    Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer

    Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer per Christoph Kahlert, Sónia A. Melo, Alexei Protopopov, Jiabin Tang, Sahil Seth, Moritz Koch, Jianhua Zhang, Juergen Weitz, Lynda Chin, P. Andrew Futreal, Raghu Kalluri

    Publicat 2014
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  2. 2
    Systematic analysis of telomere length and somatic alterations in 31 cancer types

    Systematic analysis of telomere length and somatic alterations in 31 cancer types per Floris P Barthel, Wei Wei, Ming Tang, Emmanuel Martínez-Ledesma, Xin Hu, Samirkumar B. Amin, Kadir C. Akdemir, Sahil Seth, Xingzhi Song, Qianghu Wang, Tara M. Lichtenberg, Jian Hu, Jianhua Zhang, Siyuan Zheng, Roel G.W. Verhaak

    Publicat 2017
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  3. 3
    Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

    Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma per Lawrence N. Kwong, Genevieve M. Boland, Dennie T. Frederick, Timothy L. Helms, Ahmad T. Akid, John P. Miller, Shan Jiang, Zachary A. Cooper, Xingzhi Song, Sahil Seth, Jennifer Kamara, Alexei Protopopov, Gordon B. Mills, Keith T. Flaherty, Jennifer A. Wargo, Lynda Chin

    Publicat 2015
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  4. 4
    Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

    Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma per Ana C. deCarvalho, Hoon Kim, Laila Poisson, Mary E. Winn, Claudius Mueller, David Cherba, Julie Koeman, Sahil Seth, Alexei Protopopov, Michelle M. Felicella, Siyuan Zheng, Asha S. Multani, Yongying Jiang, Jianhua Zhang, Do‐Hyun Nam, Emanuel F. Petricoin, Lynda Chin, Tom Mikkelsen, Roel G.W. Verhaak

    Publicat 2018
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  5. 5
    High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

    High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer per Gloria V. Echeverria, Emily Powell, Sahil Seth, Zhongqi Ge, Alessandro Carugo, Christopher A. Bristow, Michael Peoples, Frederick S. Robinson, Huan Qiu, Jiansu Shao, Sabrina Jeter‐Jones, Xiaomei Zhang, Vandhana Ramamoorthy, Shirong Cai, Wenhui Wu, Giulio Draetta, Stacy Moulder, W. Fraser Symmans, Jeffrey T. Chang, Timothy P. Heffernan, Helen Piwnica‐Worms

    Publicat 2018
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  6. 6
    Global impact of somatic structural variation on the DNA methylome of human cancers

    Global impact of somatic structural variation on the DNA methylome of human cancers per Yiqun Zhang, Lixing Yang, Melanie H. Kucherlapati, Angela Hadjipanayis, Angeliki Pantazi, Christopher A. Bristow, Eunjung Alice Lee, Harshad S. Mahadeshwar, Jiabin Tang, Jianhua Zhang, Sahil Seth, Semin Lee, Xiaojia Ren, Xingzhi Song, Huandong Sun, Jonathan G. Seidman, Lovelace J. Luquette, Ruibin Xi, Lynda Chin, Alexei Protopopov, Peter J. Park, Raju Kucherlapati, Chad J. Creighton

    Publicat 2019
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  7. 7
    A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases

    A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases per Yiqun Zhang, Lixing Yang, Melanie H. Kucherlapati, Fengju Chen, Angela Hadjipanayis, Angeliki Pantazi, Christopher A. Bristow, Eunjung A. Lee, Harshad S. Mahadeshwar, Jiabin Tang, Jianhua Zhang, Sahil Seth, Semin Lee, Xiaojia Ren, Xingzhi Song, Huandong Sun, Jonathan G. Seidman, Lovelace J. Luquette, Ruibin Xi, Lynda Chin, Alexei Protopopov, Wei Li, Peter J. Park, Raju Kucherlapati, Chad J. Creighton

    Publicat 2018
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  8. 8
    Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

    Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression per Petko Fiziev, Kadir C. Akdemir, John P. Miller, Emily Z. Keung, Neha S. Samant, Sneha Sharma, Christopher A. Natale, Christopher Terranova, Mayinuer Maitituoheti, Samirkumar B. Amin, Emmanuel Martínez-Ledesma, Mayura Dhamdhere, Jacob B. Axelrad, Amiksha Shah, Christine S. Cheng, Harshad S. Mahadeshwar, Sahil Seth, Michelle Barton, Alexei Protopopov, Kenneth Y. Tsai, Michael A. Davies, Benjamin A. García, Ido Amit, Lynda Chin, Jason Ernst, Kunal Rai

    Publicat 2017
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  9. 9
    Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

    Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing per Jianjun Zhang, Junya Fujimoto, Jianhua Zhang, David C. Wedge, Xingzhi Song, Jiexin Zhang, Sahil Seth, Chi‐Wan Chow, Yu Cao, Curtis Gumbs, Kathryn A. Gold, Neda Kalhor, Latasha Little, Harshad S. Mahadeshwar, César A. Moran, Alexei Protopopov, Huandong Sun, Jiabin Tang, Xifeng Wu, Yuanqing Ye, William N. William, J. Jack Lee, John V. Heymach, Waun Ki Hong, Stephen G. Swisher, Ignacio I. Wistuba, P. Andrew Futreal

    Publicat 2014
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  10. 10
    Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma

    Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma per Curtis R. Pickering, Jane H. Zhou, J. Jack Lee, Jennifer Drummond, S. Andrew Peng, Rami Saade, Kenneth Y. Tsai, Jonathan L. Curry, Michael T. Tetzlaff, Stephen Y. Lai, Jun Yu, Donna M. Muzny, HarshaVardhan Doddapaneni, Eve Shinbrot, Kyle R. Covington, Jianhua Zhang, Sahil Seth, Carlos Caulı́n, Gary L. Clayman, Adel K. El‐Naggar, Richard A. Gibbs, Randal S. Weber, Jeffrey N. Myers, David A. Wheeler, Mitchell J. Frederick

    Publicat 2014
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  11. 11
    Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

    Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors per Sahil Seth, Chieh-Yuan Li, I-Lin Ho, Denise Corti, Sara Loponte, Luigi Sapio, Edoardo Del Poggetto, Er-Yen Yen, Frederick S. Robinson, Michael Peoples, Tatiana V. Karpinets, Angela K. Deem, Tapsi Kumar, Xingzhi Song, Shan Jiang, Ya’an Kang, Jason B. Fleming, Michael P. Kim, Jianhua Zhang, Anirban Maitra, Timothy P. Heffernan, Virginia Giuliani, Giannicola Genovese, P. Andrew Futreal, Giulio Draetta, Alessandro Carugo, Andrea Viale

    Publicat 2019
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  12. 12
    Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

    Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma per Francesca Puca, Fei Yu, Caterina Bartolacci, Piergiorgio Pettazzoni, Alessandro Carugo, Emmet Huang-Hobbs, Jintan Liu, Ciro Zanca, Federica Carbone, Edoardo Del Poggetto, Joy Gumin, Pushan Dasgupta, Sahil Seth, Sanjana Srinivasan, Frederick F. Lang, Erik P. Sulman, Philip L. Lorenzi, Lin Tan, Mengrou Shan, Zachary P. Tolstyka, Maureen Kachman, Li Zhang, Sisi Gao, Angela K. Deem, Giannicola Genovese, Pier Paolo Scaglioni, Costas A. Lyssiotis, Andrea Viale, Giulio Draetta

    Publicat 2021
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  13. 13
    Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

    Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function per Andrea Viale, Piergiorgio Pettazzoni, Costas A. Lyssiotis, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani, Maria Kost‐Alimova, Florian L. Müller, Simona Colla, Luigi Nezi, Giannicola Genovese, Angela K. Deem, Avnish Kapoor, Wantong Yao, Emanuela Brunetto, Ya’an Kang, Min Yuan, John M. Asara, Yanru Wang, Timothy P. Heffernan, Alec C. Kimmelman, Huamin Wang, Jason B. Fleming, Lewis C. Cantley, Ronald A. DePinho, Giulio Draetta

    Publicat 2014
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  14. 14
    Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer

    Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer per Piergiorgio Pettazzoni, Andrea Viale, Parantu K. Shah, Alessandro Carugo, Haoqiang Ying, Huamin Wang, Giannicola Genovese, Sahil Seth, Rosalba Minelli, Tessa Green, Emmet Huang-Hobbs, Denise Corti, Nora Sánchez, Luigi Nezi, Matteo Marchesini, Avnish Kapoor, Wantong Yao, Maria Emilia Di Francesco, Alessia Petrocchi, Angela K. Deem, Kenneth L. Scott, Simona Colla, Gordon B. Mills, Jason B. Fleming, Timothy P. Heffernan, Philip Jones, Carlo Toniatti, Ronald A. DePinho, Giulio Draetta

    Publicat 2015
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  15. 15
    Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state

    Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state per Gloria V. Echeverria, Zhongqi Ge, Sahil Seth, Xiaomei Zhang, Sabrina Jeter‐Jones, Xinhui Zhou, Shirong Cai, Yizheng Tu, Aaron McCoy, Michael Peoples, Yuting Sun, Huan Qiu, Qing Chang, Christopher A. Bristow, Alessandro Carugo, Jiansu Shao, Xiaoyan Ma, Angela L. Harris, Prabhjot S. Mundi, Rosanna Lau, Vandhana Ramamoorthy, Yun Wu, Mariano J. Alvarez, Andrea Califano, Stacy Moulder, W. Fraser Symmans, Joseph R. Marszalek, Timothy P. Heffernan, Jeffrey T. Chang, Helen Piwnica‐Worms

    Publicat 2019
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  16. 16
    Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

    Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens per Traver Hart, Amy H.Y. Tong, Katie Chan, Jolanda van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery J. C. Noonan, Andrea Habsid, Olga Sizova, L. Nedyalkova, Ryan Climie, Leanne Tworzyanski, Keith A. Lawson, Maria A. Sartori, Sabriyeh Alibeh, David Tieu, Sanna N. Masud, Patricia Mero, Alexander Weiß, Kevin R. Brown, Matej Ušaj, Maximilian Billmann, Mahfuzur Rahman, Michael Costanzo, Chad L. Myers, Brenda Andrews, Charles Boone, Daniel Durocher, Jason Moffat

    Publicat 2017
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  17. 17
    Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens

    Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens per Traver Hart, Amy H.Y. Tong, Katie Chan, Jolanda van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery J. C. Noonan, Andrea Habsid, Olga Sizova, L. Nedyalkova, Ryan Climie, Keith A. Lawson, Maria A. Sartori, Sabriyeh Alibeh, David Tieu, Sanna N. Masud, Patricia Mero, Alexander Weiß, Kevin R. Brown, Matej Ušaj, Maximilian Billmann, Mahfuzur Rahman, Michael Constanzo, Chad L. Myers, Brenda Andrews, Charles Boone, Daniel Durocher, Jason Moffat

    Publicat 2017
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  18. 18
    Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure

    Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure per Kadir C. Akdemir, Victoria T. Le, Justin M. Kim, Sarah Killcoyne, D. A. King, Ya‐Ping Lin, Yanyan Tian, Akira Inoue, Samirkumar B. Amin, Frederick S. Robinson, Manjunath Nimmakayalu, Rafael E. Herrera, Erica J. Lynn, Kin Chan, Sahil Seth, Leszek J. Klimczak, Moritz Gerstung, Dmitry A. Gordenin, John O’Brien, Lei Li, Yonathan Lissanu Deribe, Roel G.W. Verhaak, Peter J. Campbell, Rebecca C. Fitzgerald, Ashby J. Morrison, Jesse R. Dixon, P. Andrew Futreal

    Publicat 2020
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  19. 19
    Phase 2 study of neoadjuvant enzalutamide and paclitaxel for luminal androgen receptor-enriched TNBC: Trial results and insights into “ARness”

    Phase 2 study of neoadjuvant enzalutamide and paclitaxel for luminal androgen receptor-enriched TNBC: Trial results and insights into “ARness” per Bora Lim, Sahil Seth, Clinton Yam, Lei Huo, Takeo Fujii, Jangsoon Lee, Roland L. Bassett, Sara Nasser, Lisa Ravenberg, Jason White, Alyson R. Clayborn, Gil Guerra‐Júnior, Jennifer K. Litton, Senthil Damodaran, Rachel M. Layman, Vicente Valero, Debasish Tripathy, Michael T. Lewis, Lacey E. Dobrolecki, Jonathan T. Lei, Rosalind P. Candelaria, Banu K. Arun, Gaiane M. Rauch, Li Zhao, Jianhua Zhang, Qingqing Ding, W. Fraser Symmans, Jeffrey T. Chang, Alastair M. Thompson, Stacy L. Moulder, Naoto T. Ueno

    Publicat 2024
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  20. 20
    Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer

    Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer per Clinton Yam, Er-Yen Yen, Jeffrey T. Chang, Roland L. Bassett, Gheath Alatrash, Haven R. Garber, Lei Huo, Fei Yang, Anne V. Philips, Qingqing Ding, Bora Lim, Naoto T. Ueno, Kasthuri Kannan, Xiangjie Sun, Baohua Sun, Edwin R. Parra, W. Fraser Symmans, Jason B. White, Elizabeth E. Ravenberg, Sahil Seth, Jennifer L. Guerriero, Gaiane M. Rauch, Senthil Damodaran, Jennifer K. Litton, Jennifer A. Wargo, Gabriel N. Hortobágyi, P. Andrew Futreal, Ignacio I. Wistuba, Ryan Sun, Stacy L. Moulder, Elizabeth A. Mittendorf

    Publicat 2021
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