Результаты поиска - Rob C. Roovers

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  1. 1
    Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains

    Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains по Karl R. Schmitz, Atrish Bagchi, Rob C. Roovers, Paul M.P. van Bergen en Henegouwen, Kathryn M. Ferguson

    Опубликовано 2013
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  2. 2
    ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding

    ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding по Shalini T. Low-Nam, Keith A. Lidke, Patrick J. Cutler, Rob C. Roovers, Paul M.P. van Bergen en Henegouwen, Bridget S. Wilson, Diane S. Lidke

    Опубликовано 2011
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  3. 3
    EGFR endocytosis requires its kinase activity and N-terminal transmembrane dimerization motif

    EGFR endocytosis requires its kinase activity and N-terminal transmembrane dimerization motif по Raimond Heukers, Jeroen F. Vermeulen, Farzad Fereidouni, Arjen N. Bader, Jarno Voortman, Rob C. Roovers, Hans C. Gerritsen, Paul M.P. van Bergen en Henegouwen

    Опубликовано 2013
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  4. 4
    Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies

    Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies по Rob C. Roovers, Toon Laeremans, Lieven Huang, Severine De Taeye, Arie J. Verkleij, Hilde Revets, Hans J. de Haard, Paul M.P. van Bergen en Henegouwen

    Опубликовано 2006
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  5. 5
    A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies

    A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies по Hans J. de Haard, Nicole van Neer, Anneke W. Reurs, Simon E. Hufton, Rob C. Roovers, Paula Henderikx, Adriaan P. de Bruı̈ne, Jan‐Willem Arends, Hennie R. Hoogenboom

    Опубликовано 1999
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  6. 6
    Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

    Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy по Mans Broekgaarden, Remko van Vught, Sabrina Oliveira, Rob C. Roovers, Paul M.P. van Bergen en Henegouwen, Roland J. Pieters, T.M. van Gulik, Eefjan Breukink, Michal Heger

    Опубликовано 2016
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  7. 7
    EGF induces coalescence of different lipid rafts

    EGF induces coalescence of different lipid rafts по Erik Hofman, Mika O. Ruonala, Arjen N. Bader, Dave van den Heuvel, Jarno Voortman, Rob C. Roovers, Arie J. Verkleij, Hans C. Gerritsen, Paul M.P. van Bergen en Henegouwen

    Опубликовано 2008
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  8. 8
    Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform

    Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform по A. Klarenbeek, Khalil El Mazouari, Aline Desmyter, Christophe Blanchetot, Anna Hultberg, Natalie De Jonge, Rob C. Roovers, Christian Cambillau, S. Spinelli, Jurgen Del‐Favero, Theo Verrips, Hans J. de Haard, Ikbel Achour

    Опубликовано 2015
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  9. 9
    Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET

    Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET по Maria J.W.D. Vosjan, Lars R. Perk, Rob C. Roovers, Gerard W.M. Visser, Marijke Stigter‐van Walsum, Paul M.P. van Bergen en Henegouwen, Guus A.M.S. van Dongen

    Опубликовано 2011
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  10. 10
    Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects

    Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects по Jeroen A. J. M. van de Water, Tugba Bagcı-Önder, Aayush S Agarwal, Hiroaki Wakimoto, Rob C. Roovers, Yanni Zhu, Randa Kasmieh, Deepak Bhere, Paul M.P. van Bergen en Henegouwen, Khalid Shah

    Опубликовано 2012
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  11. 11
    Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles

    Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles по Raimond Heukers, Işıl Altıntaş, Smiriti Raghoenath, Erica De Zan, Richard A. Pepermans, Rob C. Roovers, Rob Haselberg, Wim E. Hennink, Raymond M. Schiffelers, Robbert J. Kok, Paul M.P. van Bergen en Henegouwen

    Опубликовано 2013
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  12. 12
    Rapid Visualization of Human Tumor Xenografts through Optical Imaging with a Near-Infrared Fluorescent Anti–Epidermal Growth Factor Receptor Nanobody

    Rapid Visualization of Human Tumor Xenografts through Optical Imaging with a Near-Infrared Fluorescent Anti–Epidermal Growth Factor Receptor Nanobody по Sabrina Oliveira, Guus A.M.S. van Dongen, Marijke Stigter‐van Walsum, Rob C. Roovers, Jord C. Stam, Willem P.Th.M. Mali, P. J. van Diest, Paul M.P. van Bergen en Henegouwen

    Опубликовано 2012
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  13. 13
    Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

    Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor по Dietmar M. Zaiss, Jorg van Loosdregt, Andrea Gorlani, Cornelis P. J. Bekker, Andrea Gröne, Maria Sibilia, Paul M.P. van Bergen en Henegouwen, Rob C. Roovers, Paul J. Coffer, Alice J.A.M. Sijts

    Опубликовано 2013
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  14. 14
    A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth

    A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth по Rob C. Roovers, Maria J.W.D. Vosjan, Toon Laeremans, Rachid el Khoulati, Renée C.G. de Bruin, Kathryn M. Ferguson, Arie J. Verkleij, Guus A.M.S. van Dongen, Paul M.P. van Bergen en Henegouwen

    Опубликовано 2011
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  15. 15
    MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis

    MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis по Pieter Fokko van Loo, Basav N. Hangalapura, Soley Thordardottir, John D. Gibbins, Henrike Veninga, Linda Hendriks, Arjen Kramer, Rob C. Roovers, Marij Leenders, John de Kruif, Robert P. Doornbos, Andres Sirulnik, Mark Throsby, Ton Logtenberg, Harry Dolstra, Alexander B. H. Bakker

    Опубликовано 2019
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  16. 16
    A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies

    A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies по Roeland Lameris, Jurjen M. Ruben, Victoria Iglesias‐Guimarais, Milon de Jong, Myrthe Veth, Fleur S. van de Bovenkamp, Iris de Weerdt, Arnon P. Kater, Sonja Zweegman, Sjeng Horbach, Thilo Riedl, Benjamin Winograd, Rob C. Roovers, Anton E.P. Adang, Tanja D. de Gruijl, Paul W.H.I. Parren, Hans van Vliet

    Опубликовано 2023
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  17. 17
    A Bispecific γδ T-cell Engager Targeting EGFR Activates a Potent Vγ9Vδ2 T cell–Mediated Immune Response against EGFR-Expressing Tumors

    A Bispecific γδ T-cell Engager Targeting EGFR Activates a Potent Vγ9Vδ2 T cell–Mediated Immune Response against EGFR-Expressing Tumors по Lisa A. King, Elisa C. Toffoli, Myrthe Veth, Victoria Iglesias‐Guimarais, Manon C. Slot, Derk Amsen, Rieneke van de Ven, Sarah Derks, Marieke F. Fransen, Jurriaan B. Tuynman, Thilo Riedl, Rob C. Roovers, Anton E.P. Adang, Jurjen M. Ruben, Paul W.H.I. Parren, Tanja D. de Gruijl, Hans van Vliet

    Опубликовано 2023
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  18. 18
    A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells

    A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells по Renée C.G. de Bruin, John P. Veluchamy, Sinéad M. Lougheed, Famke L. Schneiders, Silvia Lopez‐Lastra, Roeland Lameris, Anita G.M. Stam, Zsolt Sebestyén, Jürgen Kuball, Carla F.M. Molthoff, Erik Hooijberg, Rob C. Roovers, James P. Di Santo, Paul M.P. van Bergen en Henegouwen, Henk M.W. Verheul, Tanja D. de Gruijl, Hans van Vliet

    Опубликовано 2017
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  19. 19
    The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

    The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers по Laura C. Zanetti-Domingues, Dimitris Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz‐Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M.P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco Luigi Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez

    Опубликовано 2018
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  20. 20
    Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

    Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors по Bram Herpers, Berina Eppink, Mark I. James, Carme Cortina, Adrià Cañellas‐Socias, Sylvia F. Boj, Xavier Hernando‐Momblona, Dominik Głodzik, Rob C. Roovers, Marc van de Wetering, Carina Bartelink-Clements, Vanessa Zondag-van der Zande, Jara García Mateos, Kuan Yan, Lucia Salinaro, Abdul Basmeleh, Szabolcs Fátrai, David Maussang, Jeroen J. Lammerts van Bueren, Irene Chicote, Garazi Serna, Laia Cabellos, Lorena Ramírez, Paolo Nucíforo, Ramón Salazar, Cristina Santos, Alberto Villanueva, Camille Stephan‐Otto Attolini, Elena Sancho, Héctor G. Pálmer, Josep Tabernero, Michael R. Stratton, John de Kruif, Ton Logtenberg, Hans Clevers, Leo Price, Robert G.J. Vries, Eduard Batlle, Mark Throsby

    Опубликовано 2022
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