Search Results - Rima Al‐awar

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  1. 1
    Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

    Asymmetric Synthesis of All the Known Phlegmarine Alkaloids by Bradley Wolfe, Adam H. Libby, Rima Al‐awar, Christopher J. Foti, Daniel L. Comins

    Published 2010
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  2. 2
    Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

    Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells by Natalie Grinshtein, Alessandro Datti, Mayumi Fujitani, David Uehling, Michaël Prakesch, Methvin Isaac, Meredith S. Irwin, Jeffrey L. Wrana, Rima Al‐awar, David R. Kaplan

    Published 2011
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  3. 3
    Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy

    Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy by Ryan J.O. Dowling, Sonya H.L. Lam, C. Bassi, Samar Mouaaz, Ahmed Aman, Taira Kiyota, Rima Al‐awar, Pamela J. Goodwin, Vuk Stambolic

    Published 2016
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  4. 4
    PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

    PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma by Yael Babichev, Leah Kabaroff, Alessandro Datti, David Uehling, Methvin Isaac, Rima Al‐awar, Michaël Prakesch, Ren Sun, Paul C. Boutros, Rosemarie E. Venier, Brendan C. Dickson, Rebecca Gladdy

    Published 2016
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  5. 5
    Bromo-deaza-SAH: A potent and selective DOT1L inhibitor

    Bromo-deaza-SAH: A potent and selective DOT1L inhibitor by Wenyu Yu, David Smil, Fengling Li, W. Tempel, O. Fedorov, Kong T. Nguyen, Yuri Bolshan, Rima Al‐awar, Stefan Knapp, C.H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Matthieu Schapira

    Published 2013
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  6. 6
    Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9

    Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9 by Thomas Christott, James M. Bennett, Carmen H. Coxon, Octovia Monteiro, Charline Giroud, Viktor Beke, Suet Ling Felce, Vicki Gamble, C. Gileadi, Gennady Poda, Rima Al‐awar, Gillian Farnie, Oleg Fedorov

    Published 2018
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  7. 7
    A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

    A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity by Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu Emily Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al‐awar, Aaron D. Schimmer

    Published 2021
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  8. 8
    Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

    Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth by Jiajun Zhu, Morgan A. Sammons, Greg Donahue, Zhixun Dou, Masoud Vedadi, Matthäus Getlik, Dalia Baršytė-Lovejoy, Rima Al‐awar, Bryson W. Katona, Ali Shilatifard, Jing Huang, Xianxin Hua, C.H. Arrowsmith, Shelley L. Berger

    Published 2015
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  9. 9
    Combined deletion of <scp>P</scp>ten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on e<scp>EF</scp>2<scp>K</scp>

    Combined deletion of <scp>P</scp>ten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on e<scp>EF</scp>2<scp>K</scp> by Jeff C. Liu, Véronique Voisin, Sharon Wang, Dong‐Yu Wang, Robert A. Jones, Alessandro Datti, David Uehling, Rima Al‐awar, Sean E. Egan, Gary D. Bader, Ming‐Sound Tsao, Tak W. Mak, Eldad Zacksenhaus

    Published 2014
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  10. 10
    Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

    Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction by Yuri Bolshan, Matthäus Getlik, Ekaterina Kuznetsova, Gregory A. Wasney, Taraneh Hajian, Gennadiy Poda, Kong T. Nguyen, Hong Wu, L. Dombrovski, Aiping Dong, Guillermo Senisterra, Matthieu Schapira, C.H. Arrowsmith, Peter J. Brown, Rima Al‐awar, Masoud Vedadi, David Smil

    Published 2013
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  11. 11
    Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

    Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma by Sina Haftchenary, H. Artee Luchman, Andriana O. Jouk, Anthony J. Veloso, Brent D. G. Page, Xin Cheng, Sean S.H. Dawson, Natalie Grinshtein, Vijay Shahani, Kağan Kerman, David R. Kaplan, Carly Griffin, Ahmed Aman, Rima Al‐awar, Samuel Weiss, Patrick T. Gunning

    Published 2013
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  12. 12
    Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death

    Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death by Douglas J. Mahoney, Charles Lefebvre, Kristina J. Allan, J Brun, Cina A. Sanaei, Stephen Baird, Nelson Pearce, S. A.‐M. Grönberg, Brian C. Wilson, Mikael Prakesh, Ahmed Aman, Methvin Isaac, Ahmed Mamai, David Uehling, Rima Al‐awar, Theresa Falls, Tommy Alain, David F. Stojdl

    Published 2011
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  13. 13
    Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells

    Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells by Natalie Grinshtein, Constanza Rioseco, Richard Marcellus, David Uehling, Ahmed Aman, Xueqing Lun, Osamu Muto, Lauren Podmore, Jake Lever, Yaoqing Shen, Michael Blough, G. Cairncross, Stephen M. Robbins, Steven J.M. Jones, Marco A. Marra, Rima Al‐awar, Donna L. Senger, David R. Kaplan

    Published 2016
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  14. 14
    MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

    MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis by William B. Tu, Yu-Jia Shiah, Corey Lourenco, Peter J. Mullen, Dharmendra Dingar, Cornelia Redel, Aaliya Tamachi, Wail Ba-Alawi, Ahmed Aman, Rima Al‐awar, David W. Cescon, Benjamin Haibe‐Kains, C.H. Arrowsmith, Brian Raught, Paul C. Boutros, Linda Z. Penn

    Published 2018
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  15. 15
    Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer

    Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer by Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josée Normand, Joshua Paterson, Fabrice Sircoulomb, Paul M. Krzyzanowski, Marián Novak, Sasha A. Doodnauth, Fernando Suárez, Jane Cullis, Rima Al‐awar, Benjamin G. Neel, John D. McPherson, Ronny Drapkin, Laurie Ailles, Anne‐Marie Mes‐Masson, Robert Rottapel

    Published 2017
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  16. 16
    Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

    Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5 by Guillermo Senisterra, Hong Wu, Abdellah Allali‐Hassani, Gregory A. Wasney, Dalia Baršytė-Lovejoy, L. Dombrovski, Aiping Dong, Kong T. Nguyen, David Smil, Yuri Bolshan, Taraneh Hajian, Hao He, Alma Seitova, Irene Chau, Fengling Li, Gennadiy Poda, Jean‐François Couture, Peter J. Brown, Rima Al‐awar, Matthieu Schapira, C.H. Arrowsmith, Masoud Vedadi

    Published 2012
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  17. 17
    Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

    Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers by Siyuan Song, Tania Christova, Stephen Perusini, Solmaz Alizadeh, Ren-Yue Bao, Bryan W. Miller, Rose Hurren, Yulia Jitkova, Marcela Gronda, Methvin Isaac, Babu Joseph, Ratheesh Subramaniam, Ahmed Aman, Anh Chau, Donna E. Hogge, Scott J. Weir, James M. Kasper, Aaron D. Schimmer, Rima Al‐awar, Jeffrey L. Wrana, Liliana Attisano

    Published 2011
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  18. 18
    Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

    Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2 by Renato Ferreira de Freitas, Yanli Liu, Magdalena M. Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda‐Velázquez, David Dilworth, Ronan P. Hanley, Elisa Gibson, Peter J. Brown, Rima Al‐awar, Lindsey I. James, C.H. Arrowsmith, Dalia Baršytė-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira, Abdellah Allali‐Hassani

    Published 2020
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  19. 19
    Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

    Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2 by Renato Ferreira de Freitas, Yanli Liu, Magdalena M. Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda‐Velázquez, David Dilworth, Ronan P. Hanley, Elisa Gibson, Peter J. Brown, Rima Al‐awar, Lindsey I. James, C.H. Arrowsmith, Dalia Baršytė-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira, Abdellah Allali‐Hassani

    Published 2021
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  20. 20
    Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

    Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors by Mário Sanches, Nicole M. Duffy, Manisha Talukdar, N. Thevakumaran, David Chiovitti, Marella D. Canny, Kenneth Lee, Igor Kurinov, David Uehling, Rima Al‐awar, Gennadiy Poda, Michaël Prakesch, Brian J. Wilson, Victor Tam, Colleen Schweitzer, András Toró, Julie L. Lucas, D Vuga, Lynn Lehmann, Daniel Durocher, Qingping Zeng, John B. Patterson, Frank Sicheri

    Published 2014
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