Suchergebnisse - Patrick J. Roberts

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  1. 1
    PRESYNAPTIC γ‐AMINOBUTYRIC ACID RECEPTORS IN THE RAT ANOCOCCYGEUS MUSCLE AND THEIR ANTAGONISM BY 5‐AMINOVALERIC ACID

    PRESYNAPTIC γ‐AMINOBUTYRIC ACID RECEPTORS IN THE RAT ANOCOCCYGEUS MUSCLE AND THEIR ANTAGONISM BY 5‐AMINOVALERIC ACID von M.Sherwan Muhyaddin, Patrick J. Roberts, G.N. Woodruff

    Veröffentlicht 1982
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  2. 2
    Chemotherapy and CDK4/6 Inhibitors: Unexpected Bedfellows

    Chemotherapy and CDK4/6 Inhibitors: Unexpected Bedfellows von Patrick J. Roberts, Vishnu Kumarasamy, Agnieszka K. Witkiewicz, Erik S. Knudsen

    Veröffentlicht 2020
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  3. 3
    Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression

    Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression von John E. Bisi, Jessica A. Sorrentino, Patrick J. Roberts, Francis X. Tavares, Jay C. Strum

    Veröffentlicht 2016
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  4. 4
    Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors

    Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors von John E. Bisi, Jessica A. Sorrentino, Jamie L. Jordan, David D. Darr, Patrick J. Roberts, Francis X. Tavares, Jay C. Strum

    Veröffentlicht 2017
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  5. 5
    CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury

    CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury von Derek P. DiRocco, John E. Bisi, Patrick J. Roberts, Jay C. Strum, Kwok‐Kin Wong, Norman E. Sharpless, Benjamin D. Humphreys

    Veröffentlicht 2013
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  6. 6
    Rho Family GTPase Modification and Dependence on CAAX Motif-signaled Posttranslational Modification

    Rho Family GTPase Modification and Dependence on CAAX Motif-signaled Posttranslational Modification von Patrick J. Roberts, Natalia Mitin, Patricia J. Keller, Emily J. Chenette, James P. Madigan, Rachel O. Currin, Adrienne D. Cox, Oswald Wilson, Paul T. Kirschmeier, Channing J. Der

    Veröffentlicht 2008
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  7. 7
    CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy

    CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCL... von Anne Y. Lai, Jessica A. Sorrentino, Konstantin H. Dragnev, Jared Weiss, Taofeek K. Owonikoko, Julie Rytlewski, Jill Hood, Yang Zhao, Rajesh Malik, Jay C. Strum, Patrick J. Roberts

    Veröffentlicht 2020
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  8. 8
    Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy

    Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy von Patrick J. Roberts, John E. Bisi, Jay C. Strum, Austin J. Combest, David B. Darr, Jerry Usary, William C. Zamboni, Kwok‐Kin Wong, Charles M. Perou, Norman E. Sharpless

    Veröffentlicht 2012
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  9. 9
    Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

    Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion von Shenghui He, Patrick J. Roberts, Jessica A. Sorrentino, John E. Bisi, Hannah Storrie-White, Renger G. Tiessen, Karenann M. Makhuli, William A. Wargin, Henko Tadema, Ewoud-Jan van Hoogdalem, Jay C. Strum, Rajesh Malik, Norman E. Sharpless

    Veröffentlicht 2017
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  10. 10
    Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models

    Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models von Patrick J. Roberts, Jerry Usary, David B. Darr, Patrick M. Dillon, Adam D. Pfefferle, Martin C. Whittle, James S. Duncan, Søren M. Johnson, Austin J. Combest, Jian Jin, William C. Zamboni, Gary L. Johnson, Charles M. Perou, Norman E. Sharpless

    Veröffentlicht 2012
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  11. 11
    INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

    INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors von Catherine Dietrich, Alec Trub, Antonio Ahn, Michael Taylor, Krutika Ambani, Keefe T. Chan, Kun‐Hui Lu, Christabella A. Mahendra, Catherine Blyth, Rhiannon Coulson, Susanne Ramm, April C. Watt, Sunil Kumar Matsa, John E. Bisi, Jay C. Strum, Patrick J. Roberts, Shom Goel

    Veröffentlicht 2023
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  12. 12
    Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle

    Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle von Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna R. Rosenheck, Sivasankar Putta, Alec Trub, John E. Bisi, Jay C. Strum, Patrick J. Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

    Veröffentlicht 2025
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  13. 13
    Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice

    Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice von Jerry Usary, Wei Zhao, David B. Darr, Patrick J. Roberts, Mei Liu, Lorraine Balletta, Olga Karginova, Jamie Jordan, Austin J. Combest, Arlene S. Bridges, Aleix Prat, Maggie C.U. Cheang, Jason I. Herschkowitz, Jeffrey M. Rosen, William C. Zamboni, Norman E. Sharpless, Charles M. Perou

    Veröffentlicht 2013
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  14. 14
    Alterations of LKB1 and KRAS and risk of brain metastasis: Comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma

    Alterations of LKB1 and KRAS and risk of brain metastasis: Comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma von Ni Zhao, Matthew D. Wilkerson, Usman Shah, Xiaoying Yin, Anyou Wang, Michele C. Hayward, Patrick J. Roberts, Carrie B. Lee, Alden M. Parsons, Leigh B. Thorne, Benjamin E. Haithcock, Juneko E. Grilley‐Olson, Thomas E. Stinchcombe, William K. Funkhouser, Kwok‐Kin Wong, Norman E. Sharpless, D. Neil Hayes

    Veröffentlicht 2014
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  15. 15
    Lung Squamous Cell Carcinoma mRNA Expression Subtypes Are Reproducible, Clinically Important, and Correspond to Normal Cell Types

    Lung Squamous Cell Carcinoma mRNA Expression Subtypes Are Reproducible, Clinically Important, and Correspond to Normal Cell Types von Matthew D. Wilkerson, Xiaoying Yin, Katherine A. Hoadley, Yufeng Liu, Michele C. Hayward, Christopher R. Cabanski, Kenneth L. Muldrew, C. Ryan Miller, Scott H. Randell, Mark A. Socinski, Alden M. Parsons, William K. Funkhouser, Carrie B. Lee, Patrick J. Roberts, Leigh B. Thorne, Philip S. Bernard, Charles M. Perou, D. Neil Hayes

    Veröffentlicht 2010
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  16. 16
    Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial

    Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial von J. Weiß, Tibor Csőszi, Marina Maglakelidze, Robert J. Hoyer, J.T. Beck, M. Dómine Gómez, Anna Łowczak, Raid Aljumaily, Caio M. Rocha Lima, Ralph V. Boccia, Wahid T. Hanna, Petros Nikolinakos, V.K. Chiu, Taofeek K. Owonikoko, Steven R. Schuster, Maen Hussein, Donald Richards, Piotr Sawrycki, Iurie Bulat, John Hamm, Lowell L. Hart, S. Adler, Joyce Antal, Anne Y. Lai, Jessica A. Sorrentino, Yang Zhao, Rajesh Malik, Shannon R. Morris, Patrick J. Roberts, K. Dragnev

    Veröffentlicht 2019
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  17. 17
    A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

    A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response von Chen Zhao, Katherine A. Cheng, Zandra E. Walton, Yuchuan Wang, Hiromichi Ebi, Takeshi Shimamura, Yan Liu, Tanya Tupper, Jing Ouyang, Jie Li, Peng Gao, Michele Sue‐Ann Woo, Chunxiao Xu, Masahiko Yanagita, Abigail Altabef, Shumei Wang, Charles Lee, Yuji Nakada, Christopher G. Peña, Yanping Sun, Yoko Franchetti, Catherine Yao, Amy Saur, Michael D. Cameron, Mizuki Nishino, D. Neil Hayes, Matthew D. Wilkerson, Patrick J. Roberts, Carrie B. Lee, Nabeel Bardeesy, Mohit Butaney, Lucian R. Chirieac, Daniel B. Costa, David M. Jackman, Norman E. Sharpless, Diego H. Castrillón, George D. Demetri, Pasi A. Jänne, Pier Paolo Pandolfi, Lewis C. Cantley, Andrew L. Kung, Jeffrey A. Engelman, Kwok‐Kin Wong

    Veröffentlicht 2012
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  18. 18
    CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

    CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation von Jiehui Deng, Eric S. Wang, Russell W. Jenkins, Shuai Li, Ruben Dries, Karen E. Yates, Sandeep Chhabra, Wei Huang, Hongye Liu, Amir Reza Aref, Elena Ivanova, Cloud P. Paweletz, Michaela Bowden, Chensheng W. Zhou, Grit S. Herter-Sprie, Jessica A. Sorrentino, John E. Bisi, Patrick H. Lizotte, Ashley A. Merlino, Max M. Quinn, Lauren E. Bufe, Annan Yang, Y. Zhang, Hua Zhang, Peng Gao, Ting Chen, Megan E. Cavanaugh, Amanda J. Rode, Eric Haines, Patrick J. Roberts, Jay C. Strum, William G. Richards, Jochen H. Lorch, Sareh Parangi, Viswanath Gunda, Genevieve M. Boland, Raphael Bueno, Sangeetha Palakurthi, Gordon J. Freeman, Jerome Ritz, W. Nicholas Haining, Norman E. Sharpless, Haribabu Arthanari, Geoffrey I. Shapiro, David A. Barbie, Nathanael S. Gray, Kwok‐Kin Wong

    Veröffentlicht 2017
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