Search Results - Ophélia Maertens

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  1. 1
    Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is

    Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is by Sida Liao, Ophélia Maertens, Karen Cichowski, Stephen J. Elledge

    Published 2018
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  2. 2
    Somatic Mutation Analysis in NF1 Café au lait Spots Reveals Two NF1 Hits in the Melanocytes

    Somatic Mutation Analysis in NF1 Café au lait Spots Reveals Two NF1 Hits in the Melanocytes by Sofie De Schepper, Ophélia Maertens, Tom Callens, J.M. Naeyaert, Jo Lambert, Ludwine Messiaen

    Published 2007
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  3. 3
    Defining Key Signaling Nodes and Therapeutic Biomarkers in <i>NF1</i>-Mutant Cancers

    Defining Key Signaling Nodes and Therapeutic Biomarkers in <i>NF1</i>-Mutant Cancers by Clare F. Malone, Jody Fromm Longo, Ophélia Maertens, Thomas De Raedt, Rachel Ingraham, Karen Cichowski

    Published 2014
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  4. 4
    Molecular Dissection of Isolated Disease Features in Mosaic Neurofibromatosis Type 1

    Molecular Dissection of Isolated Disease Features in Mosaic Neurofibromatosis Type 1 by Ophélia Maertens, Sofie De Schepper, Jo Vandesompele, Hilde Brems, Ine Heyns, Sandra Janssens, Frank Speleman, Eric Legius, Ludwine Messiaen

    Published 2007
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  5. 5
    mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

    mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors by Clare F. Malone, Chloe E. Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin Liu, Franziska Michor, Marcia C. Haigis, Kay F. Macleod, Ophélia Maertens, Karen Cichowski

    Published 2017
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  6. 6
    ComprehensiveNF1 screening on cultured Schwann cells from neurofibromas

    ComprehensiveNF1 screening on cultured Schwann cells from neurofibromas by Ophélia Maertens, Hilde Brems, Jo Vandesompele, Thomas De Raedt, Ine Heyns, Thorsten Rosenbaum, Sofie De Schepper, Anne De Paepe, Geert Mortier, Sandra Janssens, Frank Speleman, Eric Legius, Ludwine Messiaen

    Published 2006
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  7. 7
    Elucidating Distinct Roles for <i>NF1</i> in Melanomagenesis

    Elucidating Distinct Roles for <i>NF1</i> in Melanomagenesis by Ophélia Maertens, Bryan W. Johnson, Pablo E. Hollstein, Dennie T. Frederick, Zachary A. Cooper, Ludwine Messiaen, Roderick T. Bronson, Martin McMahon, Scott R. Granter, Keith T. Flaherty, Jennifer A. Wargo, Richard Marais, Karen Cichowski

    Published 2012
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  8. 8
    Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients

    Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients by Ophélia Maertens, Hans Prenen, Maria Dębiec‐Rychter, Agnieszka Woźniak, Raf Sciot, Patrick Pauwels, Ivo De Wever, Joris Vermeesch, Thomas De Raedt, Anne De Paepe, Frank Speleman, A. van Oosterom, Ludwine Messiaen, Eric Legius

    Published 2006
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  9. 9
    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers by Stephanie Guerra, Ophélia Maertens, Ryan Kuzmickas, Thomas De Raedt, Richard O. Adeyemi, Caroline J. Guild, Shawna Guillemette, Amanda J. Redig, Emily S. Chambers, Man Xu, Hong L. Tiv, Sandro Santagata, Pasi A. Jänne, Stephen J. Elledge, Karen Cichowski

    Published 2020
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  10. 10
    Glomus Tumors in Neurofibromatosis Type 1: Genetic, Functional, and Clinical Evidence of a Novel Association

    Glomus Tumors in Neurofibromatosis Type 1: Genetic, Functional, and Clinical Evidence of a Novel Association by Hilde Brems, Caroline Park, Ophélia Maertens, Alexander Pemov, Ludwine Messiaen, Meena Upadhyaya, Kathleen Claes, Eline Beert, Kristel Peeters, Victor Mautner, Jennifer L. Sloan, Lawrence Yao, Chyi‐Chia Richard Lee, Raf Sciot, Luc De Smet, Eric Legius, Douglas R. Stewart

    Published 2009
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  11. 11
    MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in <i>BRAF-, NRAS</i>-, and <i>NF1</i>-Mutant Melanomas

    MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in <i>BRAF-, NRAS</i>-, and <i>NF1</i>-Mutant Melanomas by Ophélia Maertens, Ryan Kuzmickas, Haley E. Manchester, Chloe E. Emerson, Alessandra G. Gavin, Caroline J. Guild, Terence C. Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi A. Garraway, Keith T. Flaherty, Shailja Pathania, Stephen J. Elledge, Karen Cichowski

    Published 2019
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  12. 12
    Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors

    Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors by Thomas De Raedt, Zandra E. Walton, Jessica L. Yecies, Danan Li, Yimei Chen, Clare F. Malone, Ophélia Maertens, Seung Min Jeong, Roderick T. Bronson, Valerie S. LeBleu, Raghu Kalluri, Emmanuel Normant, Marcia C. Haigis, Brendan D. Manning, Kwok‐Kin Wong, Kay F. Macleod, Karen Cichowski

    Published 2011
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  13. 13
    Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023)

    Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023) by AeRang Kim, Yao Lu, Scott H. Okuno, Denise K. Reinke, Ophélia Maertens, John P. Perentesis, Mitali Basu, Pamela L. Wolters, Thomas De Raedt, Sant P. Chawla, Rashmi Chugh, Brian A. Van Tine, Geraldine O’Sullivan Coyne, Alice P. Chen, Karen Cichowski, Brigitte C. Widemann

    Published 2020
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  14. 14
    Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

    Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors by Dalia Ercan, Chunxiao Xu, Masahiko Yanagita, Calixte S. Monast, Christine A. Pratilas, Joan Montero, Mohit Butaney, Takeshi Shimamura, Lynette M. Sholl, Elena Ivanova, Madhavi Tadi, Andrew M. Rogers, Claire E. Repellin, Marzia Capelletti, Ophélia Maertens, Eva M. Goetz, Anthony Letai, Levi A. Garraway, Matthew J. Lazzara, Neal Rosen, Nathanael S. Gray, Kwok‐Kin Wong, Pasi A. Jänne

    Published 2012
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  15. 15
    Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence

    Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence by Katherine R. Singleton, Lorin Crawford, Elizabeth Tsui, Haley E. Manchester, Ophélia Maertens, Xiaojing Liu, Maria V. Liberti, Anniefer N. Magpusao, Elizabeth M. Stein, Jennifer P. Tingley, Dennie T. Frederick, Genevieve M. Boland, Keith T. Flaherty, Shannon J. McCall, Clemens Krepler, Katrin Sproesser, Meenhard Herlyn, Drew Adams, Jason W. Locasale, Karen Cichowski, Sayan Mukherjee, Kris C. Wood

    Published 2017
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  16. 16
    Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer

    Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer by Sahar Nissim, Ignaty Leshchiner, Joseph D. Mancias, Matthew B. Greenblatt, Ophélia Maertens, Christopher A. Cassa, Jill A. Rosenfeld, Andrew G. Cox, John Hedgepeth, Julia Wücherpfennig, Andrew J. Kim, Jake Henderson, Patrick Gonyo, Anthony Brandt, Ellen Lorimer, Bethany Unger, Jeremy W. Prokop, Jerry R. Heidel, Xiaoxu Wang, Chinedu Ukaegbu, Benjamin C. Jennings, João A. Paulo, Sebastian Gableske, Carol A. Fierke, Gad Getz, Shamil Sunyaev, J. Wade Harper, Karen Cichowski, Alec C. Kimmelman, Yariv Houvras, Sapna Syngal, Carol L. Williams, Wolfram Goessling

    Published 2019
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