Resultats de la cerca - Mitchell R. O’Connell

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  1. 1
    Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes

    Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes per Enbo Ma, Lucas B. Harrington, Mitchell R. O’Connell, Kaihong Zhou, Jennifer A. Doudna

    Publicat 2015
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  2. 2
    RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes

    RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes per Alexandra East-Seletsky, Mitchell R. O’Connell, David Burstein, Gavin J. Knott, Jennifer A. Doudna

    Publicat 2017
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  3. 3
    RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a

    RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a per Akshay Tambe, Alexandra East-Seletsky, Gavin J. Knott, Jennifer A. Doudna, Mitchell R. O’Connell

    Publicat 2018
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  4. 4
    Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a

    Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a per Souvik Sinha, Adrian M. Molina Vargas, Pablo Arantes, Amun C. Patel, Mitchell R. O’Connell, Giulia Palermo

    Publicat 2023
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  5. 5
    Programmable RNA recognition and cleavage by CRISPR/Cas9

    Programmable RNA recognition and cleavage by CRISPR/Cas9 per Mitchell R. O’Connell, Benjamin L. Oakes, Samuel H. Sternberg, Alexandra East-Seletsky, Matias Kaplan, Jennifer A. Doudna

    Publicat 2014
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  6. 6
    Programmable RNA Tracking in Live Cells with CRISPR/Cas9

    Programmable RNA Tracking in Live Cells with CRISPR/Cas9 per David A. Nelles, Mark Y. Fang, Mitchell R. O’Connell, Jia Xu, Sebastian Markmiller, Jennifer A. Doudna, G Yeo

    Publicat 2016
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  7. 7
    Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

    Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection per Alexandra East-Seletsky, Mitchell R. O’Connell, Spencer C. Knight, David Burstein, J.H.D. Cate, Robert Tjian, Jennifer A. Doudna

    Publicat 2016
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  8. 8
    Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme

    Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme per Gavin J. Knott, Alexandra East-Seletsky, Joshua C. Cofsky, James M. Holton, Emeric Charles, Mitchell R. O’Connell, Jennifer A. Doudna

    Publicat 2017
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  9. 9
    Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense

    Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense per Arica R. VanderWal, Jung-Un Park, Bogdan Polevoda, Julia K. Nicosia, Adrian M. Molina Vargas, Elizabeth H. Kellogg, Mitchell R. O’Connell

    Publicat 2023
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  10. 10
    New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity

    New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity per Adrian M. Molina Vargas, Souvik Sinha, Raven M. Osborn, Pablo Arantes, Amun C. Patel, Stephen Dewhurst, Dwight J. Hardy, Andrew Cameron, Giulia Palermo, Mitchell R. O’Connell

    Publicat 2023
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  11. 11
    Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing

    Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing per Jacob Waitkus, Yu Chang, Li Liu, Srinivasu Valagerahally Puttaswamy, Taerin Chung, Adrian M. Molina Vargas, Stephen J. Dollery, Mitchell R. O’Connell, Haogang Cai, Gregory J. Tobin, Nikhil Bhalla, Ke Du

    Publicat 2022
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  12. 12
    THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder

    THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder per Martin Broly, Bogdan Polevoda, Kamel Awayda, Ning Tong, Jenna M. Lentini, Thomas Besnard, Wallid Deb, Declan O’Rourke, Júlia Baptista, Sian Ellard, Mohammed Almannai, Mais Hashem, Ferdous Abdulwahab, Hanan E. Shamseldin, Saeed M Al-Tala, Fowzan S. Alkuraya, A. S. Leon, Rosa Laura E. van Loon, Alessandra Ferlini, Mariabeatrice Sanchini, Stefania Bigoni, Andrea Ciorba, Hans van Bokhoven, Zafar Iqbal, Almundher Al‐Maawali, Fathiya Al-Murshedi, Anuradha Ganesh, Watfa Al‐Mamari, Sze Chern Lim, Lynn Pais, Natasha J. Brown, Saima Riazuddin, Stéphane Bézieau, Dragony Fu, Bertrand Isidor, Benjamin Cogné, Mitchell R. O’Connell

    Publicat 2022
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  13. 13
    Transfer RNA acetylation regulates in vivo mammalian stress signaling

    Transfer RNA acetylation regulates in vivo mammalian stress signaling per Supuni Thalalla Gamage, Roxane Khoogar, Shereen Howpay Manage, Judey T. DaRos, McKenna C. Crawford, Joe Georgeson, Bogdan Polevoda, Chelsea Sanders, Kendall A. Lee, Kellie D. Nance, Vinithra Iyer, Anatoly Kustanovich, Minervo Perez, Chu T. Thu, Sam R. Nance, Ruhul Amin, Christine N. Miller, Ronald J. Holewinski, Sudipto Das, Thomas J. Meyer, Vishal N. Kopardé, Acong Yang, Parthav Jailwala, Joe Nguyen, Þorkell Andrésson, Kent W. Hunter, Shuo Gu, Beverly A. Mock, Elijah F. Edmondson, Simone Difilippantonio, Raj Chari, Schraga Schwartz, Mitchell R. O’Connell, Colin Chih‐Chien Wu, Jordan L. Meier

    Publicat 2025
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