Search Results - Michelle C. Schaeffer

  • Showing 1 - 7 results of 7
Refine Results
  1. 1
    Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

    Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice by Scott B. Berger, Viera Kasparcova, Sandy Hoffman, Barb Swift, Lauren Dare, Michelle C. Schaeffer, Carol A. Capriotti, Michael N. Cook, Joshua N. Finger, Angela Hughes‐Earle, Philip A. Harris, William J. Kaiser, Edward S. Mocarski, John Bertin, Peter J. Gough

    Published 2014
    Get full text
    Artigo
    Save to List
    Saved in:
  2. 2
    Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

    Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase by SB Berger, Philip A. Harris, Rakesh Nagilla, Viera Kasparcova, Sandra C. Hoffman, Brandon Swift, Lauren Dare, Michelle C. Schaeffer, Carol A. Capriotti, Michael T. Ouellette, BW King, David D. Wisnoski, Julie A. Cox, Michael Reilly, RW Marquis, John Bertin, PJ Gough

    Published 2015
    Get full text Get full text
    Artigo
    Save to List
    Saved in:
  3. 3
    Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

    Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis by Philip A. Harris, Deepak Bandyopadhyay, Scott B. Berger, Nino Campobasso, Carol A. Capriotti, Julie A. Cox, Lauren Dare, Joshua N. Finger, Sandra J. Hoffman, Kirsten M. Kahler, Ruth Lehr, John D. Lich, Rakesh Nagilla, Robert T. Nolte, Michael T. Ouellette, Christina Pao, Michelle C. Schaeffer, Angela Smallwood, Helen H. Sun, Barbara A. Swift, Rachel D. Totoritis, Paris Ward, Robert W. Marquis, John Bertin, Peter J. Gough

    Published 2013
    Get full text
    Artigo
    Save to List
    Saved in:
  4. 4
    Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

    Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock by Pratyusha Mandal, Yanjun Feng, John D. Lyons, Scott B. Berger, Shunsuke Otani, Alexandra DeLaney, Gregory K. Tharp, Kristal Maner-Smith, Eileen M. Burd, Michelle C. Schaeffer, Sandra J. Hoffman, Carol A. Capriotti, Linda Roback, Cedrick Young, Zhe Liang, Eric A. Ortlund, Nelson C. DiPaolo, Steven E. Bosinger, John Bertin, Peter J. Gough, Igor E. Brodsky, Craig M. Coopersmith, Dmitry M. Shayakhmetov, Edward S. Mocarski

    Published 2018
    Get full text Get full text
    Artigo
    Save to List
    Saved in:
  5. 5
    DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

    DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors by Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay, Scott B. Berger, Nino Campobasso, Carol A. Capriotti, Julie A. Cox, Lauren Dare, Xiaoyang Dong, Joshua N. Finger, LaShadric C. Grady, Sandra J. Hoffman, Jae Uk Jeong, James Kang, Viera Kasparcova, Ami S. Lakdawala, Ruth Lehr, Dean E. McNulty, Rakesh Nagilla, Michael T. Ouellette, Christina Pao, Alan R. Rendina, Michelle C. Schaeffer, Jennifer D. Summerfield, Barbara A. Swift, Rachel D. Totoritis, Paris Ward, Aming Zhang, Daohua Zhang, Robert W. Marquis, John Bertin, Peter J. Gough

    Published 2016
    Get full text
    Artigo
    Save to List
    Saved in:
  6. 6
    Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

    Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinaz... by Pamela A. Haile, Linda Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh Mahajan, Michael Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, M.A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis

    Published 2019
    Get full text Get full text
    Artigo
    Save to List
    Saved in:
  7. 7
    Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

    Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase by Philip A. Harris, Nicolas Faucher, Nicolas George, Patrick M. Eidam, Bryan W. King, Gemma V. White, Niall A. Anderson, Deepak Bandyopadhyay, Allison M. Beal, Véronique Bénéton, Scott B. Berger, Nino Campobasso, Sébastien Campos, Carol A. Capriotti, Julie A. Cox, Alain Daugan, Frédéric Donche, Marie-Hélène Fouchet, Joshua N. Finger, Brad J. Geddes, Peter J. Gough, Pascal Grondin, Bonnie L. Hoffman, Sandra J. Hoffman, Susan E. Hutchinson, Jae Uk Jeong, Émilie Jigorel, P. Lamoureux, Lara K. Leister, John D. Lich, Mukesh Mahajan, Jamel Meslamani, J. Mosley, Rakesh Nagilla, Pamela Nassau, Sze‐Ling Ng, Michael T. Ouellette, Kishore Kumar Pasikanti, Florent Potvain, Michael Reilly, Elizabeth J. Rivera, Stéphane Sautet, Michelle C. Schaeffer, Clark A. Sehon, Helen H. Sun, James H. Thorpe, Rachel D. Totoritis, Paris Ward, Natalie Wellaway, David D. Wisnoski, James M. Woolven, John Bertin, Robert W. Marquis

    Published 2019
    Get full text
    Artigo
    Save to List
    Saved in:

Search Tools: