Resultados da busca - Michelle C. Schaeffer

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  1. 1
    Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

    Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice por Scott B. Berger, Viera Kasparcova, Sandy Hoffman, Barb Swift, Lauren Dare, Michelle C. Schaeffer, Carol A. Capriotti, Michael N. Cook, Joshua N. Finger, Angela Hughes‐Earle, Philip A. Harris, William J. Kaiser, Edward S. Mocarski, John Bertin, Peter J. Gough

    Publicado em 2014
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  2. 2
    Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

    Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase por SB Berger, Philip A. Harris, Rakesh Nagilla, Viera Kasparcova, Sandra C. Hoffman, Brandon Swift, Lauren Dare, Michelle C. Schaeffer, Carol A. Capriotti, Michael T. Ouellette, BW King, David D. Wisnoski, Julie A. Cox, Michael Reilly, RW Marquis, John Bertin, PJ Gough

    Publicado em 2015
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  3. 3
    Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

    Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis por Philip A. Harris, Deepak Bandyopadhyay, Scott B. Berger, Nino Campobasso, Carol A. Capriotti, Julie A. Cox, Lauren Dare, Joshua N. Finger, Sandra J. Hoffman, Kirsten M. Kahler, Ruth Lehr, John D. Lich, Rakesh Nagilla, Robert T. Nolte, Michael T. Ouellette, Christina Pao, Michelle C. Schaeffer, Angela Smallwood, Helen H. Sun, Barbara A. Swift, Rachel D. Totoritis, Paris Ward, Robert W. Marquis, John Bertin, Peter J. Gough

    Publicado em 2013
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  4. 4
    Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

    Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock por Pratyusha Mandal, Yanjun Feng, John D. Lyons, Scott B. Berger, Shunsuke Otani, Alexandra DeLaney, Gregory K. Tharp, Kristal Maner-Smith, Eileen M. Burd, Michelle C. Schaeffer, Sandra J. Hoffman, Carol A. Capriotti, Linda Roback, Cedrick Young, Zhe Liang, Eric A. Ortlund, Nelson C. DiPaolo, Steven E. Bosinger, John Bertin, Peter J. Gough, Igor E. Brodsky, Craig M. Coopersmith, Dmitry M. Shayakhmetov, Edward S. Mocarski

    Publicado em 2018
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  5. 5
    DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

    DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors por Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay, Scott B. Berger, Nino Campobasso, Carol A. Capriotti, Julie A. Cox, Lauren Dare, Xiaoyang Dong, Joshua N. Finger, LaShadric C. Grady, Sandra J. Hoffman, Jae Uk Jeong, James Kang, Viera Kasparcova, Ami S. Lakdawala, Ruth Lehr, Dean E. McNulty, Rakesh Nagilla, Michael T. Ouellette, Christina Pao, Alan R. Rendina, Michelle C. Schaeffer, Jennifer D. Summerfield, Barbara A. Swift, Rachel D. Totoritis, Paris Ward, Aming Zhang, Daohua Zhang, Robert W. Marquis, John Bertin, Peter J. Gough

    Publicado em 2016
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  6. 6
    Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

    Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinaz... por Pamela A. Haile, Linda Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh Mahajan, Michael Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, M.A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis

    Publicado em 2019
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  7. 7
    Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

    Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase por Philip A. Harris, Nicolas Faucher, Nicolas George, Patrick M. Eidam, Bryan W. King, Gemma V. White, Niall A. Anderson, Deepak Bandyopadhyay, Allison M. Beal, Véronique Bénéton, Scott B. Berger, Nino Campobasso, Sébastien Campos, Carol A. Capriotti, Julie A. Cox, Alain Daugan, Frédéric Donche, Marie-Hélène Fouchet, Joshua N. Finger, Brad J. Geddes, Peter J. Gough, Pascal Grondin, Bonnie L. Hoffman, Sandra J. Hoffman, Susan E. Hutchinson, Jae Uk Jeong, Émilie Jigorel, P. Lamoureux, Lara K. Leister, John D. Lich, Mukesh Mahajan, Jamel Meslamani, J. Mosley, Rakesh Nagilla, Pamela Nassau, Sze‐Ling Ng, Michael T. Ouellette, Kishore Kumar Pasikanti, Florent Potvain, Michael Reilly, Elizabeth J. Rivera, Stéphane Sautet, Michelle C. Schaeffer, Clark A. Sehon, Helen H. Sun, James H. Thorpe, Rachel D. Totoritis, Paris Ward, Natalie Wellaway, David D. Wisnoski, James M. Woolven, John Bertin, Robert W. Marquis

    Publicado em 2019
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