Resultados de procura - Michael Ohlmeyer

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  1. 1
    Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

    Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration por Andrew R. Clark, Michael Ohlmeyer

    Publicado 2019
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  2. 2
    Reengineered tricyclic anti-cancer agents

    Reengineered tricyclic anti-cancer agents por David B. Kastrinsky, Jaya Sangodkar, Nilesh Zaware, Sudeh Izadmehr, Neil S. Dhawan, Goutham Narla, Michael Ohlmeyer

    Publicado 2015
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  3. 3
    Complex synthetic chemical libraries indexed with molecular tags.

    Complex synthetic chemical libraries indexed with molecular tags. por Michael Ohlmeyer, R. N. Swanson, Lawrence W. Dillard, John Reader, G Asouline, Ryouji KOBAYASHI, Michael Wigler, W. Clark Still

    Publicado 1993
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  4. 4
    Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains

    Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains por Guangtao Zhang, A.N. Plotnikov, E. V. Rusinova, Tong Shen, Keita Morohashi, Jennifer Joshua, Lei Zeng, Shiraz Mujtaba, Michael Ohlmeyer, Ming‐Ming Zhou

    Publicado 2013
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  5. 5
    Direct observation of small molecule activator binding to single PR65 protein

    Direct observation of small molecule activator binding to single PR65 protein por Annie Yang-Schulz, Maria Zacharopoulou, Sema Zeynep Yilmaz, Anupam Banerjee, Satyaki Saha, Daniel Nietlispach, Michael Ohlmeyer, Mert Gür, Laura S. Itzhaki, İvet Bahar, Reuven Gordon

    Publicado 2025
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  6. 6
    A paradigm for drug discovery employing encoded combinatorial libraries.

    A paradigm for drug discovery employing encoded combinatorial libraries. por Jonathan J. Burbaum, Michael Ohlmeyer, Jocelyn Reader, Ian Henderson, Lawrence W. Dillard, G Li, Troy L. Randle, N H Sigal, Daniel Chelsky, John J. Baldwin

    Publicado 1995
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  7. 7
    Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer’s Disease Pathogenesis in Cell and Animal Models

    Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer’s Disease Pathogenesis in Cell and Animal Models por Hui Wei, Huiliang Zhang, Xiaochuan Wang, Jia‐Zhao Xie, Dandan An, Lu Wan, Jian‐Zhi Wang, Yi Zeng, Xiji Shu, Jukka Westermarck, Youming Lu, Michael Ohlmeyer, Rong Liu

    Publicado 2020
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  8. 8
    Direct activation of PP2A for the treatment of tyrosine kinase inhibitor–resistant lung adenocarcinoma

    Direct activation of PP2A for the treatment of tyrosine kinase inhibitor–resistant lung adenocarcinoma por Rita Tohmé, Sudeh Izadmehr, Sai Gandhe, Giancarlo Tabaro, Sanjay Vallabhaneni, Ava Thomas, Neal Vasireddi, Neil S. Dhawan, Avi Ma’ayan, Neelesh Sharma, Matthew D. Galsky, Michael Ohlmeyer, Jaya Sangodkar, Goutham Narla

    Publicado 2019
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  9. 9
    Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma

    Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma por Joni Merisaari, Oxana V. Denisova, Milena Doroszko, Vadim Le Joncour, Patrik Johansson, William P. J. Leenders, David B. Kastrinsky, Nilesh Zaware, Goutham Narla, Pirjo Laakkonen, Sven Nelander, Michael Ohlmeyer, Jukka Westermarck

    Publicado 2020
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  10. 10
    Protein Phosphatase 2A Reduces Cigarette Smoke–induced Cathepsin S and Loss of Lung Function

    Protein Phosphatase 2A Reduces Cigarette Smoke–induced Cathepsin S and Loss of Lung Function por Declan Doherty, Sridesh Nath, Justin Poon, Robert Foronjy, Michael Ohlmeyer, Abdoulaye Dabo, Matthias Salathé, Mark A. Birrell, Maria G. Belvisi, Nathalie Baumlin, Michael D. Kim, Sinéad Weldon, Clifford C. Taggart, Patrick Geraghty

    Publicado 2019
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  11. 11
    Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition

    Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition por Guangtao Zhang, Ruijie Liu, Yifei Zhong, A.N. Plotnikov, Weijia Zhang, Lei Zeng, E. V. Rusinova, Guillermo Gerona-Nevarro, Natasha Moshkina, Jennifer Joshua, Peter Y. Chuang, Michael Ohlmeyer, John Cijiang He, Ming‐Ming Zhou

    Publicado 2012
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  12. 12
    BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy

    BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy por Miguel F. Segura, Bárbara Fontanals-Cirera, Avital Gaziel‐Sovran, María V. Guijarro, Douglas Hanniford, Guangtao Zhang, Pilar González‐Gómez, Marta Morante, Luz Jubierre, Weijia Zhang, Farbod Darvishian, Michael Ohlmeyer, Iman Osman, Ming‐Ming Zhou, Eva Hernando

    Publicado 2013
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  13. 13
    PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

    PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells por Otto Kauko, Caitlin M. O’Connor, Evgeny Kulesskiy, Jaya Sangodkar, Anna Aakula, Sudeh Izadmehr, Laxman Yetukuri, Bhagwan Yadav, Artur Padzik, Teemu D. Laajala, Pekka Haapaniemi, Majid Momeny, Taru Varila, Michael Ohlmeyer, Tero Aittokallio, Krister Wennerberg, Goutham Narla, Jukka Westermarck

    Publicado 2018
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  14. 14
    Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

    Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes por Raffaella Di Micco, Bárbara Fontanals-Cirera, Vivien Low, Panagiotis Ntziachristos, Stephanie K. Yuen, Claudia D. Lovell, Igor Dolgalev, Yoshiya Yonekubo, Guangtao Zhang, E. V. Rusinova, Guillermo Gerona‐Navarro, Marta Cañamero, Michael Ohlmeyer, Iannis Aifantis, Ming-Ming Zhou, Aristotelis Tsirigos, Eva Hernando

    Publicado 2014
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  15. 15
    Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma

    Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma por Brittany L. Allen-Petersen, Tyler Risom, Zipei Feng, Zhiping Wang, Zina P. Jenny, Mary C. Thoma, Katherine R. Pelz, Jennifer P. Morton, Owen J. Sansom, Charles D. Lopez, Brett C. Sheppard, Dale J. Christensen, Michael Ohlmeyer, Goutham Narla, Rosalie C. Sears

    Publicado 2018
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  16. 16
    Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

    Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response por Jaya Sangodkar, Neil S. Dhawan, Heather Melville, Varan Singh, Rui Yuan, Huma Q. Rana, Sudeh Izadmehr, Caroline Farrington, Sahar Mazhar, Suzanna Katz, Tara Albano, Pearlann Arnovitz, Rachel A. Okrent, Michael Ohlmeyer, Matthew D. Galsky, David Burstein, David Zhang, Katerina Politi, Analisa DiFeo, Goutham Narla

    Publicado 2012
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  17. 17
    BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

    BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice por Ka‐Lung Cheung, Geming Lu, Rajal Sharma, Adam Vincek, Ruihua Zhang, A.N. Plotnikov, Fan Zhang, Qiang Zhang, Ying Ju, Yuan Hu, Li Zhao, Xinye Han, Jamel Meslamani, Feihong Xu, Anbalagan Jaganathan, Tong Shen, Hongfa Zhu, E. V. Rusinova, Lei Zeng, Jiachi Zhou, Jianjun Yang, Liang Peng, Michael Ohlmeyer, Martin J. Walsh, David Y. Zhang, Huabao Xiong, Ming‐Ming Zhou

    Publicado 2017
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  18. 18
    Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

    Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry por Kirk McMillan, Marc Adler, Douglas S. Auld, John J. Baldwin, Eric Blasko, Leslie J. Browne, Daniel Chelsky, David D. Davey, Ronald E. Dolle, Keith Eagen, Shawn D. Erickson, Richard I. Feldman, Charles B. Glaser, Cornell Mallari, Michael M. Morrissey, Michael Ohlmeyer, Gonghua Pan, John F. Parkinson, Gary B. Phillips, Mark A. Polokoff, N H Sigal, Ronald Vergona, Marc Whitlow, Tish Young, James J. Devlin

    Publicado 2000
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  19. 19
    Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

    Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells por Garry L. Coles, Sandra Cristea, James T. Webber, Rebecca S. Levin, Steven M. Moss, Andy He, Jaya Sangodkar, Yeonjoo Hwang, Julia Arand, Alexandros P. Drainas, Nancie A. Mooney, János Demeter, Jessica N. Spradlin, Brandon Mauch, Vicky Le, Yan Ting Shue, Julie H. Ko, Myung Chang Lee, Christina S. Kong, Daniel K. Nomura, Michael Ohlmeyer, Danielle L. Swaney, Nevan J. Krogan, Peter K. Jackson, Goutham Narla, John D. Gordan, Kevan M. Shokat, Julien Sage

    Publicado 2020
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  20. 20
    Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

    Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer por Kimberly McClinch, Rita A. Avelar, David Callejas, Sudeh Izadmehr, Danica Wiredja, Abbey Perl, Jaya Sangodkar, David B. Kastrinsky, Daniela Schlatzer, Max Cooper, Janna Kiselar, Agnes Stachnik, Yao Shen, Divya Hoon, Daniel McQuaid, Nilesh Zaware, Yixuan Gong, David L. Brautigan, Stephen R. Plymate, Cynthia C.T. Sprenger, William Oh, Alice C. Levine, Alexander Kirschenbaum, John P. Sfakianos, Rosalie C. Sears, Analisa DiFeo, Yiannis A. Ioannou, Michael Ohlmeyer, Goutham Narla, Matthew D. Galsky

    Publicado 2018
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