Resultats de la cerca - Krishnapriya Chinnaswamy

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  1. 1
    Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

    Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors per Ran Xu, Yujun Zhao, Liu Liu, Longchuan Bai, Chao‐Yie Yang, Bing Zhou, Jennifer L. Meagher, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Shaomeng Wang

    Publicat 2015
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  2. 2
    Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands

    Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands per Xin Han, Lijie Zhao, Weiguo Xiang, Chong Qin, Bukeyan Miao, Tianfeng Xu, Mi Wang, Chao‐Yie Yang, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Shaomeng Wang

    Publicat 2019
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  3. 3
    Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <i>In Vivo</i> Antitumor Activity

    Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <i>In Vivo</i> Antitumor Activity per Shilin Xu, Angelo Aguilar, Liyue Huang, Tianfeng Xu, Ke Zheng, Donna McEachern, Sally Przybranowski, C.L. Foster, Kaitlin P. Zawacki, Zhaomin Liu, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Shaomeng Wang

    Publicat 2020
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  4. 4
    SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

    SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression per Haibin Zhou, Longchuan Bai, Renqi Xu, Donna McEachern, Krishnapriya Chinnaswamy, Ruiting Li, Bo Wen, Mi Wang, Chao‐Yie Yang, Jennifer L. Meagher, Duxin Sun, Jeanne A. Stuckey, Shaomeng Wang

    Publicat 2021
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  5. 5
    High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction

    High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction per Haibin Zhou, Weihua Zhou, Bing Zhou, Liu Liu, Ting‐Rong Chern, Krishnapriya Chinnaswamy, Jianfeng Lü, Denzil Bernard, Chao‐Yie Yang, Shasha Li, Mi Wang, Jeanne A. Stuckey, Yi Sun, Shaomeng Wang

    Publicat 2018
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  6. 6
    A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

    A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation per Haibin Zhou, Jianfeng Lü, Liu Liu, Denzil Bernard, Chao-Yie Yang, Ester Fernández‐Salas, Krishnapriya Chinnaswamy, Stephanie Danielle Layton, Jeanne A. Stuckey, Qing Yu, Weihua Zhou, Zhen‐Qiang Pan, Yi Sun, Shaomeng Wang

    Publicat 2017
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  7. 7
    Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

    Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor per Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura, Elizabeth K. Ziemke, Jeanne A. Stuckey, Si Li, Krishnapriya Chinnaswamy, Hiroyuki Otake, Bikash Debnath, V. N. Yarovenko, Judith S. Sebolt‐Leopold, Mats Ljungman, Nouri Neamati

    Publicat 2016
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  8. 8
    Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction

    Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction per Shilin Xu, Angelo Aguilar, Tianfeng Xu, Ke Zheng, Liyue Huang, Jeanne A. Stuckey, Krishnapriya Chinnaswamy, Denzil Bernard, Ester Fernández‐Salas, Liu Liu, Mi Wang, Donna McEachern, Sally Przybranowski, C.L. Foster, Shaomeng Wang

    Publicat 2017
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  9. 9
    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo per Longchuan Bai, Haibin Zhou, Renqi Xu, Yujun Zhao, Krishnapriya Chinnaswamy, Donna McEachern, Jianyong Chen, Chao‐Yie Yang, Zhaomin Liu, Mi Wang, Liu Liu, Hui Jiang, Bo Wen, Praveen Kumar, Jennifer L. Meagher, Duxin Sun, Jeanne A. Stuckey, Shaomeng Wang

    Publicat 2019
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  10. 10
    Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

    Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein per Haibin Zhou, Longchuan Bai, Renqi Xu, Yujun Zhao, Jianyong Chen, Donna McEachern, Krishnapriya Chinnaswamy, Bo Wen, Lipeng Dai, Praveen Kumar, Chao‐Yie Yang, Zhaomin Liu, Mi Wang, Liu Liu, Jennifer L. Meagher, Yi Han, Duxin Sun, Jeanne A. Stuckey, Shaomeng Wang

    Publicat 2019
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