Resultados de búsqueda - Judith S. Sebolt‐Leopold

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  1. 1
    MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

    MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice por Meredith A. Collins, Wei Yan, Judith S. Sebolt‐Leopold, Marina Pasca di Magliano

    Publicado 2013
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  2. 2
    Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer

    Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer por Daniel Gioeli, Winfried Wunderlich, Judith S. Sebolt‐Leopold, Stefan Bekiranov, Julia Wulfkuhle, Emanuel F. Petricoin, Mark Conaway, Michael J. Weber

    Publicado 2011
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  3. 3
    Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor

    Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor por Marcian E. Van Dort, Stefanie Galbán, Hanxiao Wang, Judith S. Sebolt‐Leopold, Christopher E. Whitehead, Hao Hong, Alnawaz Rehemtulla, Brian D. Ross

    Publicado 2015
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  4. 4
    Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6

    Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6 por Elizabeth K. Ziemke, Joseph S. Dosch, Joel D. Maust, Amrith Shettigar, Ananda Sen, Theodore H. Welling, Karin M. Hardiman, Judith S. Sebolt‐Leopold

    Publicado 2015
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  5. 5
    3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition

    3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition por David B. Solit, Elmer Santos, Christine A. Pratilas, Jose Lobo, Maxim A. Moroz, Shangde Cai, Ronald Blasberg, Judith S. Sebolt‐Leopold, Steven M. Larson, Neal Rosen

    Publicado 2007
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  6. 6
    The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer

    The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer por Patrick Klein, C. Max Schmidt, Chad Wiesenauer, Jennifer Choi, Earl A. Gage, Michele Yip-Schneider, Eric A. Wiebke, Yufang Wang, Charles A. Omer, Judith S. Sebolt‐Leopold

    Publicado 2006
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  7. 7
    Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer por Terence M. Williams, Athena R. Flecha, Paul R. Keller, Ashwin N. Ram, David Karnak, Stefanie Galbán, Craig J. Galbán, Brian D. Ross, Theodore S. Lawrence, Alnawaz Rehemtulla, Judith S. Sebolt‐Leopold

    Publicado 2012
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  8. 8
    A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance

    A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance por Christopher E. Whitehead, Elizabeth K. Ziemke, Christy L. Frankowski-McGregor, Rachel Mumby, June Hee Chung, Jinju Li, Nathaniel Osher, Oluwadara Coker, Veerabhadran Baladandayuthapani, Scott Kopetz, Judith S. Sebolt‐Leopold

    Publicado 2024
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  9. 9
    Costello and cardio‐facio‐cutaneous syndromes: Moving toward clinical trials in RASopathies

    Costello and cardio‐facio‐cutaneous syndromes: Moving toward clinical trials in RASopathies por Katherine A. Rauen, Anuradha Banerjee, W. Robert Bishop, Jennifer Lauchle, Frank McCormick, Martin McMahon, Teri Mélèse, Pamela N. Münster, Sorena Nadaf, Roger J. Packer, Judith S. Sebolt‐Leopold, David Viskochil

    Publicado 2011
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  10. 10
    Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

    Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1 por Huabing Zhang, Sadeesh K. Ramakrishnan, Daniel Triner, Brook Centofanti, Dhiman Maitra, Balázs Győrffy, Judith S. Sebolt‐Leopold, Michael K. Dame, James Varani, Dean E. Brenner, Eric R. Fearon, M. Bishr Omary, Yatrik M. Shah

    Publicado 2015
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  11. 11
    Prospective Analysis of Parametric Response Map–Derived MRI Biomarkers: Identification of Early and Distinct Glioma Response Patterns Not Predicted by Standard Radiographic Assessment

    Prospective Analysis of Parametric Response Map–Derived MRI Biomarkers: Identification of Early and Distinct Glioma Response Patterns Not Predicted by Standard Radiographic Assessm... por Craig J. Galbán, Thomas L. Chenevert, Charles R. Meyer, Christina Tsien, Theodore S. Lawrence, Daniel A. Hamstra, Larry Junck, Pia C. Sundgren, Timothy D. Johnson, Stefanie Galbán, Judith S. Sebolt‐Leopold, Alnawaz Rehemtulla, Brian D. Ross

    Publicado 2011
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  12. 12
    BRAF mutation predicts sensitivity to MEK inhibition

    BRAF mutation predicts sensitivity to MEK inhibition por David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith S. Sebolt‐Leopold, William R. Sellers, Neal Rosen

    Publicado 2005
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  13. 13
    Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

    Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor por Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura, Elizabeth K. Ziemke, Jeanne A. Stuckey, Si Li, Krishnapriya Chinnaswamy, Hiroyuki Otake, Bikash Debnath, V. N. Yarovenko, Judith S. Sebolt‐Leopold, Mats Ljungman, Nouri Neamati

    Publicado 2016
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  14. 14
    Phase I and Pharmacodynamic Study of the Oral MEK Inhibitor CI-1040 in Patients With Advanced Malignancies

    Phase I and Pharmacodynamic Study of the Oral MEK Inhibitor CI-1040 in Patients With Advanced Malignancies por Patricia LoRusso, Alex A. Adjei, Mary Varterasian, Shirish M. Gadgeel, Joel M. Reid, David Mitchell, Lorelei J. Hanson, Pamela DeLuca, Laura M. Bruzek, Jill Piens, Peggy Asbury, Keri Van Becelaere, Román Herrera, Judith S. Sebolt‐Leopold, Mark B. Meyer

    Publicado 2005
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  15. 15
    Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

    Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras por Jennifer Lauchle, Doris Kim, Doan Le, Keiko Akagi, Michael Crone, Kimberly Krisman, Kegan Warner, Jeannette M. Bonifas, Qing Li, Kristen M. Coakley, Ernesto Díaz-Flores, Matthew F. Gorman, Sally Przybranowski, Mary Tran, Scott C. Kogan, Jeroen P. Roose, Neal G. Copeland, Nancy A. Jenkins, Luis F. Parada, Linda Wolff, Judith S. Sebolt‐Leopold, Kevin Shannon

    Publicado 2009
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  16. 16
    Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back

    Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back por Katherine A. Rauen, Lisa Schoyer, Frank McCormick, Angela E. Lin, Judith Allanson, David A. Stevenson, Karen W. Gripp, Giovanni Neri, John C. Carey, Eric Legius, Marco Tartaglia, Suzanne Schubbert, Amy E. Roberts, Bruce D. Gelb, Kevin Shannon, David H. Gutmann, Martin McMahon, Carmen Guerra, James A. Fagin, Benjamin Yu, Yoko Aoki, Benjamin G. Neel, Allan Balmain, Richard R. Drake, Garry P. Nolan, Martin Zenker, Gideon Bollag, Judith S. Sebolt‐Leopold, W. Wayt Gibbs, Alcino J. Silva, E. Elizabeth Patton, David Viskochil, Mark W. Kieran, Bruce R. Korf, Randi J. Hagerman, Roger J. Packer, Teri Mélèse

    Publicado 2009
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