Search Results - Joshua M. Dempster

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  1. 1
    Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines

    Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines by Joshua M. Dempster, Jordan Rossen, Mariya Kazachkova, Joshua Pan, Guillaume Kugener, David E. Root, Aviad Tsherniak

    Published 2019
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  2. 2
    Chronos: a CRISPR cell population dynamics model

    Chronos: a CRISPR cell population dynamics model by Joshua M. Dempster, Isabella Boyle, Francisca Vázquez, David E. Root, Jesse S. Boehm, William C. Hahn, Aviad Tsherniak, James M. McFarland

    Published 2021
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  3. 3
    Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

    Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects by Joshua M. Dempster, Isabella Boyle, Francisca Vázquez, David E. Root, Jesse S. Boehm, William C. Hahn, Aviad Tsherniak, James M. McFarland

    Published 2021
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  4. 4
    Comparative optimization of combinatorial CRISPR screens

    Comparative optimization of combinatorial CRISPR screens by Ruitong Li, Olaf Klingbeil, Davide Monducci, Michael J. Young, Diego J. Rodriguez, Zaid Bayyat, Joshua M. Dempster, Devishi Kesar, Xiaoping Yang, Mahdi Zamanighomi, Christopher R. Vakoc, Takahiro Ito, William R. Sellers

    Published 2022
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  5. 5
    Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

    Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal by John M. Krill-Burger, Joshua M. Dempster, Ashir A. Borah, Brenton R. Paolella, David E. Root, Todd R. Golub, Jesse S. Boehm, William C. Hahn, James M. McFarland, Francisca Vázquez, Aviad Tsherniak

    Published 2023
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  6. 6
    Integrated cross-study datasets of genetic dependencies in cancer

    Integrated cross-study datasets of genetic dependencies in cancer by Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoç, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio

    Published 2021
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  7. 7
    Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

    Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration by James M. McFarland, Zandra V. Ho, Guillaume Kugener, Joshua M. Dempster, Phillip G. Montgomery, Jordan Bryan, John M. Krill-Burger, Thomas Green, Francisca Vázquez, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Aviad Tsherniak

    Published 2018
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  8. 8
    Mapping the landscape of genetic dependencies in chordoma

    Mapping the landscape of genetic dependencies in chordoma by Tanaz Sharifnia, Mathias J. Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M. Dempster, Sandrine Muller, Joan Levy, Daniel M. Freed, Josh Sommer, Jérémie Kalfon, Francisca Vázquez, William C. Hahn, David E. Root, Paul A. Clemons, Stuart L. Schreiber

    Published 2023
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  9. 9
    Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

    Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets by Joshua M. Dempster, Clare Pacini, Sasha Pantel, Fiona M. Behan, Thomas Green, John M. Krill-Burger, Charlotte Beaver, Scott T. Younger, Victor Zhivich, Hanna Najgebauer, Felicity Allen, Emanuel Gonçalves, Rebecca Shepherd, John G. Doench, Kosuke Yusa, Francisca Vázquez, Leopold Parts, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio

    Published 2019
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  10. 10
    A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas

    A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas by Lisa D. Cervia, Tsukasa Shibue, Ashir A. Borah, Benjamin Gaeta, Linh He, Lisa Leung, Naomi Li, Sydney M. Moyer, Brian Shim, Nancy Dumont, Alfredo González, Nolan Bick, Mariya Kazachkova, Joshua M. Dempster, John M. Krill-Burger, Federica Piccioni, Namrata D. Udeshi, Meagan E. Olive, Steven A. Carr, David E. Root, James M. McFarland, Francisca Vázquez, William C. Hahn

    Published 2022
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  11. 11
    Noncanonical open reading frames encode functional proteins essential for cancer cell survival

    Noncanonical open reading frames encode functional proteins essential for cancer cell survival by John R. Prensner, Oana M. Enache, Victor Luria, Karsten Krug, Karl R. Clauser, Joshua M. Dempster, Amir Karger, Li Wang, Karolina Stumbraite, Vickie M. Wang, Ginevra Botta, Nicholas Lyons, Amy Goodale, Zohra Kalani, Briana Fritchman, Adam Brown, Douglas Alan, Thomas Green, Xiaoping Yang, Jacob D. Jaffe, Jennifer A. Roth, Federica Piccioni, Marc W. Kirschner, Zhe Ji, David E. Root, Todd R. Golub

    Published 2021
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  12. 12
    SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO

    SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO by Patrícia Cristine Borck, Isabella Boyle, Kristina Janković, Nolan Bick, Kyla Foster, Anthony C. Lau, Lucy Parker-Burns, Daniel A. Lubicki, Tianxia Li, Ashir A. Borah, Nicholas J. Lofaso, Sohani Das Sharma, Timothy A. Chan, Riya V. Kishen, Anisah Adeagbo, Srivatsan Raghavan, Elisa Aquilanti, John R. Prensner, John M. Krill-Burger, Todd R. Golub, Catarina D. Campbell, Joshua M. Dempster, Edmond M. Chan, Francisca Vázquez

    Published 2025
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  13. 13
    A first-generation pediatric cancer dependency map

    A first-generation pediatric cancer dependency map by Neekesh V. Dharia, Guillaume Kugener, Lillian M. Guenther, Clare F. Malone, Adam D. Durbin, Andrew L. Hong, Thomas P. Howard, Pratiti Bandopadhayay, Caroline S. Wechsler, Iris Fung, Allison Warren, Joshua M. Dempster, John M. Krill-Burger, Brenton R. Paolella, Phoebe Moh, Nishant Jha, Andrew Tang, Philip Montgomery, Jesse S. Boehm, William C. Hahn, Charles W.M. Roberts, James M. McFarland, Aviad Tsherniak, Todd R. Golub, Francisca Vázquez, Kimberly Stegmaier

    Published 2021
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  14. 14
    Genetic and transcriptional evolution alters cancer cell line drug response

    Genetic and transcriptional evolution alters cancer cell line drug response by Uri Ben‐David, Benjamin A. Siranosian, Gavin Ha, Helen Tang, Yaara Oren, Kunihiko Hinohara, Craig A. Strathdee, Joshua M. Dempster, Nicholas Lyons, Robert Burns, Anwesha Nag, Guillaume Kugener, Beth A. Cimini, Peter Tsvetkov, Yosef E. Maruvka, Ryan O’Rourke, Anthony J. Garrity, Andrew A. Tubelli, Pratiti Bandopadhayay, Aviad Tsherniak, Francisca Vázquez, Bang Wong, Chet Birger, Mahmoud Ghandi, Aaron R. Thorner, Joshua A. Bittker, Matthew Meyerson, Gad Getz, Rameen Beroukhim, Todd R. Golub

    Published 2018
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  15. 15
    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers by Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, Emma Pailler, Timothy L. Bosse, Maneesha Thaker, Diego Almanza, Joshua M. Dempster, Joshua Pan, Federica Piccioni, Nancy Dumont, Alfredo González, Jonathan Rennhack, Behnam Nabet, John A. Bachman, Amy Goodale, Yenarae Lee, Mukta Bagul, Rosy Liao, Adrija J. Navarro, Tina L. Yuan, Raymond W.S. Ng, Srivatsan Raghavan, Nathanael S. Gray, Aviad Tsherniak, Francisca Vázquez, David E. Root, Ari Firestone, Jeff Settleman, William C. Hahn, Andrew J. Aguirre

    Published 2019
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  16. 16
    Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

    Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer by Daniel P. Bondeson, Brenton R. Paolella, Adhana Asfaw, Michael Rothberg, Thomas A. Skipper, Carly R. Langan, Gabriel Mesa, Alfredo González, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William Colgan, Allison Warren, Joshua M. Dempster, John M. Krill-Burger, Maria Ericsson, Andrew Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John G. Doench, Federica Piccioni, David E. Root, Jesse S. Boehm, William C. Hahn, Michael Mannstadt, James M. McFarland, Francisca Vázquez, Todd R. Golub

    Published 2022
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  17. 17
    Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

    Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models by Samuel Y. Ng, Noriaki Yoshida, Amanda L. Christie, Mahmoud Ghandi, Neekesh V. Dharia, Joshua M. Dempster, Mark A. Murakami, Kay Shigemori, Sara Morrow, Alexandria Van Scoyk, Nicolas A. Cordero, Kristen E. Stevenson, Mäneka Puligandla, Brian J. Haas, Christopher Lo, Robin M. Meyers, Galen F. Gao, Andrew D. Cherniack, Abner Louissaint, Valentina Nardi, Aaron R. Thorner, Henry W. Long, Xintao Qiu, Elizabeth A. Morgan, David M. Dorfman, Danilo Fiore, Julie K. Jang, Alan L. Epstein, Ahmet Doǧan, Yanming Zhang, Steven M. Horwitz, Eric D. Jacobsen, Solimar Santiago, Jian-Guo Ren, Vincent Guerlavais, D. Allen Annis, Manuel Aivado, Mansoor N. Saleh, Amitkumar Mehta, Aviad Tsherniak, David E. Root, Francisca Vázquez, William C. Hahn, Giorgio Inghirami, Jon C. Aster, David M. Weinstock, Raphael Koch

    Published 2018
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  18. 18
    BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

    BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma by Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh V. Dharia, Deyao Li, Samantha E. Hoffman, Guillaume Kugener, McKenzie Shaw, Hafsa M. Mire, Olivia A. Hack, Joshua M. Dempster, Caleb A. Lareau, Lingling Dai, Logan H. Sigua, Michael A. Quezada, Ann-Catherine J. Stanton, Meghan Wyatt, Zohra Kalani, Amy Goodale, Francisca Vázquez, Federica Piccioni, John G. Doench, David E. Root, Jamie N. Anastas, Kristen L. Jones, Amy Saur Conway, Sylwia A. Stopka, Michael S. Regan, Yu Liang, Hyuk‐Soo Seo, Kijun Song, Puspalata Bashyal, William P. Jerome, Nathan D. Mathewson, Sirano Dhe‐Paganon, Mario L. Suvà, Ángel M. Carcaboso, Cinzia Lavarino, Jaume Mora, Quang‐Dé Nguyen, Keith L. Ligon, Yang Shi, Sameer Agnihotri, Nathalie Y.R. Agar, Kimberly Stegmaier, Charles D. Stiles, Michelle Monje, Todd R. Golub, Jun Qi, Mariella G. Filbin

    Published 2022
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