Search Results - Joseph A. Marsh

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  1. 1
    Alpha Helices Are More Robust to Mutations than Beta Strands

    Alpha Helices Are More Robust to Mutations than Beta Strands by György Abrusán, Joseph A. Marsh

    Published 2016
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  2. 2
    Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations

    Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations by Benjamin Livesey, Joseph A. Marsh

    Published 2020
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  3. 3
    The properties of human disease mutations at protein interfaces

    The properties of human disease mutations at protein interfaces by Benjamin Livesey, Joseph A. Marsh

    Published 2022
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  4. 4
    Diverse Molecular Mechanisms Underlying Pathogenic Protein Mutations: Beyond the Loss-of-Function Paradigm

    Diverse Molecular Mechanisms Underlying Pathogenic Protein Mutations: Beyond the Loss-of-Function Paradigm by Lisa Backwell, Joseph A. Marsh

    Published 2022
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  5. 5
    Interpreting protein variant effects with computational predictors and deep mutational scanning

    Interpreting protein variant effects with computational predictors and deep mutational scanning by Benjamin Livesey, Joseph A. Marsh

    Published 2022
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  6. 6
    Large protein complex interfaces have evolved to promote cotranslational assembly

    Large protein complex interfaces have evolved to promote cotranslational assembly by Mihaly Badonyi, Joseph A. Marsh

    Published 2022
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  7. 7
    Buffering of genetic dominance by allele-specific protein complex assembly

    Buffering of genetic dominance by allele-specific protein complex assembly by Mihaly Badonyi, Joseph A. Marsh

    Published 2023
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  8. 8
    Updated benchmarking of variant effect predictors using deep mutational scanning

    Updated benchmarking of variant effect predictors using deep mutational scanning by Benjamin Livesey, Joseph A. Marsh

    Published 2023
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  9. 9
    Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes

    Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes by Mihaly Badonyi, Joseph A. Marsh

    Published 2025
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  10. 10
    Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins

    Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins by Fawzy Mohamed, Joseph A. Marsh

    Published 2025
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  11. 11
    Variant effect predictor correlation with functional assays is reflective of clinical classification performance

    Variant effect predictor correlation with functional assays is reflective of clinical classification performance by Benjamin Livesey, Joseph A. Marsh

    Published 2025
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  12. 12
    Relative Solvent Accessible Surface Area Predicts Protein Conformational Changes upon Binding

    Relative Solvent Accessible Surface Area Predicts Protein Conformational Changes upon Binding by Joseph A. Marsh, Sarah A. Teichmann

    Published 2011
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  13. 13
    Protein Flexibility Facilitates Quaternary Structure Assembly and Evolution

    Protein Flexibility Facilitates Quaternary Structure Assembly and Evolution by Joseph A. Marsh, Sarah A. Teichmann

    Published 2014
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  14. 14
    How do proteins gain new domains?

    How do proteins gain new domains? by Joseph A. Marsh, Sarah A. Teichmann

    Published 2010
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  15. 15
    Functional determinants of protein assembly into homomeric complexes

    Functional determinants of protein assembly into homomeric complexes by L. Therese Bergendahl, Joseph A. Marsh

    Published 2017
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  16. 16
    Predicting pathogenic protein variants

    Predicting pathogenic protein variants by Joseph A. Marsh, Sarah A. Teichmann

    Published 2023
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  17. 17
    Sequence Determinants of Compaction in Intrinsically Disordered Proteins

    Sequence Determinants of Compaction in Intrinsically Disordered Proteins by Joseph A. Marsh, Julie D. Forman‐Kay

    Published 2010
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  18. 18
    Identification of pathogenic missense mutations using protein stability predictors

    Identification of pathogenic missense mutations using protein stability predictors by Lukas Gerasimavicius, Xin Liu, Joseph A. Marsh

    Published 2020
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  19. 19
    Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure

    Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure by Lukas Gerasimavicius, Benjamin Livesey, Joseph A. Marsh

    Published 2022
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  20. 20
    Correspondence between functional scores from deep mutational scans and predicted effects on protein stability

    Correspondence between functional scores from deep mutational scans and predicted effects on protein stability by Lukas Gerasimavicius, Benjamin Livesey, Joseph A. Marsh

    Published 2023
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