Search Results - Jianwei Che

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  1. 1
    Covalent drugs targeting histidine – an unexploited opportunity?

    Covalent drugs targeting histidine – an unexploited opportunity? by Jianwei Che, Lyn H. Jones

    Published 2022
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  2. 2
    Targeting<i>MET</i>Dysregulation in Cancer

    Targeting<i>MET</i>Dysregulation in Cancer by Gonzalo Recondo, Jianwei Che, Pasi A. Jänne, Mark M. Awad

    Published 2020
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    Revisão
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  3. 3
    Latest Trend of Milk Derived Exosomes: Cargos, Functions, and Applications

    Latest Trend of Milk Derived Exosomes: Cargos, Functions, and Applications by Xin Feng, Xiaolin Chen, Xucan Zheng, Hui Zhu, Qien Qi, Shen Liu, Huihua Zhang, Jianwei Che

    Published 2021
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  4. 4
    Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library

    Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library by Chelsea E. Powell, Guangyan Du, Jianwei Che, Zhixiang He, Katherine A. Donovan, Hong Yue, Eric S. Wang, Radosław P. Nowak, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray

    Published 2020
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  5. 5
    Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2

    Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2 by Guangyan Du, Jie Jiang, Qibiao Wu, Nathaniel J. Henning, Katherine A. Donovan, Hong Yue, Jianwei Che, Wenchao Lu, Eric S. Fischer, Nabeel Bardeesy, Tinghu Zhang, Nathanael S. Gray

    Published 2021
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  6. 6
    Expanding the Diversity of Allosteric Bcr-Abl Inhibitors

    Expanding the Diversity of Allosteric Bcr-Abl Inhibitors by Xianming Deng, Okram Barun, Qiang Ding, Jianming Zhang, Yongmun Choi, Francisco Adrián, Amy Wojciechowski, Guobao Zhang, Jianwei Che, Badry Bursulaya, Sandra W. Cowan‐Jacob, Gabriele Rummel, Taebo Sim, Nathanael S. Gray

    Published 2010
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  7. 7
    Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells

    Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells by Yang Sun, Lu Hu, Zhipeng Tao, Gopala K. Jarugumilli, Hannah Erb, Alka Singh, Qi Li, Jennifer L. Cotton, Patricia Greninger, Regina K. Egan, Y. Tony Ip, Cyril H. Benes, Jianwei Che, Junhao Mao, Xu Wu

    Published 2022
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  8. 8
    Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

    Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator by Shifeng Pan, Nathanael S. Gray, Wenqi Gao, Yuan Mi, Yi Fan, Xing Wang, Tove Tuntland, Jianwei Che, Sophie Lefebvre, Yu Chen, Alan Chu, Klaus Hinterding, Anne Gardin, Peter End, Peter Heining, Christian Bruns, Nigel G. Cooke, Barbara Nuesslein‐Hildesheim

    Published 2013
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  9. 9
    Discovery and resistance mechanism of a selective CDK12 degrader

    Discovery and resistance mechanism of a selective CDK12 degrader by Baishan Jiang, Yang Gao, Jianwei Che, Wenchao Lu, Ines H. Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J. Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M. Riching, Danette L. Daniels, Peter K. Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S. Gray

    Published 2021
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  10. 10
    Cereblon covalent modulation through structure-based design of histidine targeting chemical probes

    Cereblon covalent modulation through structure-based design of histidine targeting chemical probes by Justin T. Cruite, Geoffrey P. Dann, Jianwei Che, Katherine A. Donovan, Silas Ferrao, Scott B. Ficarro, Eric S. Fischer, Nathanael S. Gray, Fidel Huerta, Nikki R. Kong, Hu Liu, Jarrod A. Marto, Rebecca J. Metivier, Radosław P. Nowak, Breanna L. Zerfas, Lyn H. Jones

    Published 2022
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  11. 11
    Exploring the target scope of KEAP1 E3 ligase-based PROTACs

    Exploring the target scope of KEAP1 E3 ligase-based PROTACs by Guangyan Du, Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak, Katherine A. Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A. Eleuteri, Zhixiang He, Zhengnian Li, Hubert T. Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray

    Published 2022
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  12. 12
    Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor

    Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor by Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk‐Soo Seo, Ekaterina V. Vinogradova, Tomer M. Yaron, Evanna L. Mills, Haopeng Xiao, Kristine Senkane, Emily M. Huntsman, Jared L. Johnson, Jianwei Che, Lewis C. Cantley, Benjamin F. Cravatt, Sirano Dhe‐Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S. Gray, Edward T. Chouchani

    Published 2023
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  13. 13
    Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

    Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors by Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y. Kim, Xijun Zhu, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Stephen M. Hinshaw, Behnam Nabet, Steven M. Corsello, Nicholas Kwiatkowski, Jarrod A. Marto, Tinghu Zhang, Nathanael S. Gray

    Published 2023
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  14. 14
    The human zinc-binding cysteine proteome

    The human zinc-binding cysteine proteome by Nils Burger, Melanie J. Mittenbühler, Haopeng Xiao, Sang-Hee Shin, Shelley M Wei, Erik Henze, Sebastian Schindler, Sepideh Mehravar, David M. Wood, Jonathan J. Petrocelli, Yizhi Sun, Hans‐Georg Sprenger, Pedro Latorre‐Muro, Amanda L. Smythers, Luiz H. M. Bozi, Narek Darabedian, Yingde Zhu, Hyuk‐Soo Seo, Sirano Dhe‐Paganon, Jianwei Che, Edward T. Chouchani

    Published 2024
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  15. 15
    Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14–Mutant NSCLC

    Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14–Mutant NSCLC by Gonzalo Recondo, Magda Bahcall, Liam F. Spurr, Jianwei Che, Biagio Ricciuti, Giulia C. Leonardi, Ying‐Chun Lo, Yvonne Y. Li, Giuseppe Lamberti, Tom Nguyen, Marina S.D. Milan, Deepti Venkatraman, Renato Umeton, Cloud P. Paweletz, Adem Albayrak, Andrew D. Cherniack, Kristin S. Price, Stephen R. Fairclough, Mizuki Nishino, Lynette M. Sholl, Geoffrey R. Oxnard, Pasi A. Jänne, Mark M. Awad

    Published 2020
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  16. 16
    Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

    Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling by Mengyang Fan, Wenchao Lu, Jianwei Che, Nicholas Kwiatkowski, Yang Gao, Hyuk‐Soo Seo, Scott B. Ficarro, Prafulla C. Gokhale, Yao Liu, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Joseph D. Mancias, Jarrod A. Marto, Sirano Dhe‐Paganon, Tinghu Zhang, Nathanael S. Gray

    Published 2022
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  17. 17
    (<i>R</i>)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors

    (<i>R</i>)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors by Ha-Soon Choi, Paul V. Rucker, Zhicheng Wang, Yi Fan, Pamela Albaugh, Greg Chopiuk, F. Gessier, Fangxian Sun, Francisco Adrián, Guoxun Liu, Tami Hood, Nanxin Li, Yong Jia, Jianwei Che, Susan McCormack, Allen Li, Jie Li, Auzon Steffy, AnneMarie Culazzo, Celine Tompkins, Van Phung, Andreas Kreusch, Min Lu, Bin Hu, Apurva Chaudhary, Mahavir Prashad, Tove Tuntland, Bo Liu, Jennifer L. Harris, H. Martin Seidel, Jon C. Loren, Valentina Molteni

    Published 2015
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  18. 18
    Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

    Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development by Katherine A. Donovan, Fleur M. Ferguson, Jonathan W. Bushman, Nicholas A. Eleuteri, Debabrata Bhunia, SeongShick Ryu, Li Tan, Kun Shi, Hong Yue, Xiaoxi Liu, Dennis Dobrovolsky, Baishan Jiang, Jinhua Wang, Mingfeng Hao, Inchul You, Mingxing Teng, Yanke Liang, John M. Hatcher, Zhengnian Li, Theresa Manz, Brian J. Groendyke, Wanyi Hu, Yunju Nam, Sandip Sengupta, Hanna Cho, Injae Shin, Michael P. Agius, Irene M. Ghobrial, W Michelle, Jianwei Che, Sara J. Buhrlage, Taebo Sim, Nathanael S. Gray, Eric S. Fischer

    Published 2020
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  19. 19
    Imaging of <i>Plasmodium</i> Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

    Imaging of <i>Plasmodium</i> Liver Stages to Drive Next-Generation Antimalarial Drug Discovery by Stephan Meister, David Plouffe, Kelli Kuhen, Ghislain M. C. Bonamy, Tao Wu, S. Whitney Barnes, Selina Bopp, Rachel Borboa, A. Taylor Bright, Jianwei Che, Steve Cohen, Neekesh V. Dharia, Kerstin Gagaring, Montip Gettayacamin, Perry Gordon, Todd Groessl, Nobutaka Kato, Lee M, Case W. McNamara, David A. Fidock, A. S. Nagle, Tae‐gyu Nam, Wendy Richmond, Jason Roland, Matthias Rottmann, Bin Zhou, Patrick Froissard, Richard Glynne, Dominique Mazier, Jetsumon Sattabongkot, Peter G. Schultz, Tove Tuntland, John R. Walker, Yingyao Zhou, Arnab K. Chatterjee, Thierry T. Diagana, Elizabeth A. Winzeler

    Published 2011
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  20. 20
    Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

    Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 by Jun Liu, Shifeng Pan, Mindy H. Hsieh, Nicholas Ng, Fangxian Sun, Tao Wang, Shailaja Kasibhatla, Alwin G. Schuller, Allen G. Li, Cheng Dai, Jie Li, Celin Tompkins, AnneMarie Pferdekamper, Auzon Steffy, Jane Cheng, Colleen Kowal, Van Phung, Gui-Rong Guo, Yan Wang, Martin P. Graham, Shannon Flynn, J. Chad Brenner, Chun Li, Maria Cristina Villarroel, Peter G. Schultz, Xu Wu, Peter McNamara, William R. Sellers, Lilli Petruzzelli, Anthony Boral, H. Martin Seidel, Margaret E. McLaughlin, Jianwei Che, Thomas E. Carey, Gary Vanasse, Jennifer L. Harris

    Published 2013
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