检索结果 - James Tsai
- Showing 1 - 6 results of 6
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Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase 由 Weiru Wang, Adhirai Marimuthu, James Tsai, Abhinav Kumar, Heike I. Krupka, Chao Zhang, Ben Powell, Yoshihisa Suzuki, Hoa Nguyen, M. Tabrizizad, Catherine A. Luu, Brian L. West
出版 2006Artigo -
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PLX4032, a potent inhibitor of the B‐Raf V600E oncogene, selectively inhibits V600E‐positive melanomas 由 John Tayu Lee, Ling Li, Patricia Brafford, Marcia van den Eijnden, Molly B. Halloran, Katrin Sproesser, Nikolas K. Haass, Keiran S.M. Smalley, James Tsai, Gideon Bollag, Meenhard Herlyn
出版 2010Artigo -
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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner 由 Eric W. Joseph, Christine A. Pratilas, Poulikos I. Poulikakos, Madhavi Tadi, Weiqing Wang, Barry S. Taylor, Ensar Halilovic, Yogindra Persaud, Feng Xing, Agnès Viale, James Tsai, Paul B. Chapman, Gideon Bollag, David B. Solit, Neal Rosen
出版 2010Artigo -
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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity 由 James Tsai, John Tayu Lee, Weiru Wang, Jiazhong Zhang, Hanna Cho, Shumeye Mamo, Ryan Bremer, S. Gillette, Jun Kong, Nikolas K. Haass, Katrin Sproesser, Ling Li, Keiran S.M. Smalley, Daniel W. Fong, Yongliang Zhu, Adhirai Marimuthu, Hoa Nguyen, Billy Lam, Jennifer Liu, Ivana Cheung, Julie Rice, Yoshihisa Suzuki, Catherine A. Luu, Calvin Settachatgul, Rafe Shellooe, John Cantwell, Sung‐Hou Kim, Joseph Schlessinger, Kam Y. J. Zhang, Brian L. West, Ben Powell, Gaston Habets, Chao Zhang, Prabha N. Ibrahim, Peter Hirth, Dean R. Artis, Meenhard Herlyn, Gideon Bollag
出版 2008Artigo -
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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma 由 Gideon Bollag, Peter Hirth, James Tsai, Jiazhong Zhang, Prabha N. Ibrahim, Hanna Cho, Wayne Spevak, Chao Zhang, Ying Zhang, Gaston Habets, Elizabeth A. Burton, Bernice H. Wong, Garson Tsang, Brian L. West, Ben Powell, Rafe Shellooe, Adhirai Marimuthu, Hoa Nguyen, Kam Y. J. Zhang, Dean R. Artis, Joseph Schlessinger, Fei Su, Brian Higgins, Raman Iyer, Kurt D’Andrea, Astrid Koehler, Michael Stumm, Paul Lin, Richard J. Lee, Joseph F. Grippo, Igor Puzanov, Kevin B. Kim, Antoni Ribas, Grant A. McArthur, Jeffrey A. Sosman, Paul B. Chapman, Keith T. Flaherty, Xiaowei Xu, Katherine L. Nathanson, K. B. Nolop
出版 2010Artigo
相关主题
Biology
Cancer research
Gene
Biochemistry
Kinase
V600E
Cancer
Genetics
Internal medicine
Medicine
Melanoma
Mutation
Cell biology
Cell cycle
Chemistry
MAPK/ERK pathway
MEK inhibitor
Mutant
Phosphorylation
Apoptosis
Bacteria
Cell growth
Clinical trial
Colorectal cancer
Concomitant
Enzyme
KRAS
Molecular biology
Oncogene
Oncology