Search Results - J. Robert Dorkin

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  1. 1
    <i>In Vitro</i>–<i>In Vivo</i> Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery

    <i>In Vitro</i>–<i>In Vivo</i> Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery by Kathryn A. Whitehead, J. Matthews, Philip Chang, Farnaz Niroui, J. Robert Dorkin, Mariano Severgnini, Daniel G. Anderson

    Published 2012
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  2. 2
    Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

    Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy by Matthias A. Oberli, Andreas M. Reichmuth, J. Robert Dorkin, Michael J. Mitchell, Owen S. Fenton, Ana Jaklenec, Daniel G. Anderson, Róbert Langer, Daniel Blankschtein

    Published 2016
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  3. 3
    Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

    Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse by Kevin Kauffman, Matthias A. Oberli, J. Robert Dorkin, Juan E. Hurtado, James C. Kaczmarek, Shivani Bhadani, Jeff Wyckoff, Róbert Langer, Ana Jaklenec, Daniel G. Anderson

    Published 2017
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  4. 4
    Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system

    Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system by Frank DeRosa, Braydon C. Guild, Shrirang Karve, L Smith, Kevin T. Love, J. Robert Dorkin, Kevin Kauffman, J Zhang, Barak Yahalom, Daniel G. Anderson, Michael W. Heartlein

    Published 2016
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  5. 5
    Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

    Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery by Owen S. Fenton, Kevin Kauffman, Rebecca L. McClellan, Eric A. Appel, J. Robert Dorkin, Mark W. Tibbitt, Michael W. Heartlein, Frank DeRosa, Róbert Langer, Daniel G. Anderson

    Published 2016
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  6. 6
    Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

    Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo by Yizhou Dong, J. Robert Dorkin, Weiheng Wang, Philip Chang, Matthew J. Webber, Benjamin C. Tang, Junghoon Yang, Inbal Abutbul‐Ionita, Dganit Danino, Frank DeRosa, Michael W. Heartlein, Róbert Langer, Daniel G. Anderson

    Published 2016
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  7. 7
    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver by Akin Akinc, Michael S. Goldberg, June Qin, J. Robert Dorkin, Christina Gamba‐Vitalo, Martin A. Maier, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Muthiah Manoharan, Victor Koteliansky, Ingo Röhl, Elizaveta S. Leshchiner, Róbert Langer, Daniel G. Anderson

    Published 2009
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  8. 8
    Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

    Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity by Kathryn A. Whitehead, J. Robert Dorkin, Arturo J. Vegas, Philip Chang, Omid Veiseh, J. Matthews, Owen S. Fenton, Yunlong Zhang, Karsten Olejnik, Volkan Yesilyurt, Delai Chen, Scott Barros, Boris Klebanov, Tatiana I. Novobrantseva, Róbert Langer, Daniel G. Anderson

    Published 2014
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  9. 9
    Lipid‐Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

    Lipid‐Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo by Yizhou Dong, Ahmed A. Eltoukhy, Christopher A. Alabi, Omar F. Khan, Omid Veiseh, J. Robert Dorkin, Sasilada Sirirungruang, Hao Yin, Benjamin C. Tang, Jeisa M. Pelet, Delai Chen, Zhen Gu, Yuan Xue, Róbert Langer, Daniel G. Anderson

    Published 2014
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  10. 10
    Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo

    Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo by Elena M. Smekalova, María Guadalupe Martínez, Emmanuel Combe, Anuj Kumar, Selam Dejene, Dominique Leboeuf, Chao‐Ying Chen, J. Robert Dorkin, Lan Shuang, Sarah Kieft, Lauren Young, Luis Barrera, Michael S. Packer, Giuseppe Ciaramella, Barbara Testoni, Francine M. Gregoire, Fabien Zoulim

    Published 2023
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  11. 11
    Lipid-like materials for low-dose, in vivo gene silencing

    Lipid-like materials for low-dose, in vivo gene silencing by Kevin T. Love, Kerry P. Mahon, Christopher G. Levins, Kathryn A. Whitehead, William Querbes, J. Robert Dorkin, June Qin, William Cantley, Liu Liang Qin, Timothy Racie, Maria Frank-Kamenetsky, Ka Ning Yip, Rene Alvarez, Dinah W.Y. Sah, Antonin de Fougerolles, Kevin Fitzgerald, Victor Koteliansky, Akin Akinc, Róbert Langer, Daniel G. Anderson

    Published 2010
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  12. 12
    Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

    Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo by Hao Yin, Chun‐Qing Song, J. Robert Dorkin, Lihua Julie Zhu, Yingxiang Li, Qiongqiong Wu, Angela Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet Fatih Bolukbasi, Stephen C. Walsh, Roman L. Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A. Wolfe, Róbert Langer, Wen Xue, Daniel G. Anderson

    Published 2016
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  13. 13
    Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

    Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms by Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, William Cantley, J. Robert Dorkin, James S. Butler, LiuLiang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J. Hope, Marino Zerial, Dinah W.Y. Sah, Kevin Fitzgerald, Mark A. Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A. Maier

    Published 2010
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  14. 14
    Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

    Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates by Yizhou Dong, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yunlong Zhang, Delai Chen, Roman L. Bogorad, Hao Yin, Yi Chen, Arturo J. Vegas, Christopher A. Alabi, Gaurav Sahay, Karsten Olejnik, Weiheng Wang, Avi Schroeder, Abigail K. R. Lytton‐Jean, Daniel J. Siegwart, Akin Akinc, Carmen Barnes, Scott Barros, Mary Carioto, Kevin Fitzgerald, Julia Hettinger, Varun Kumar, Tatiana I. Novobrantseva, June Qin, William Querbes, Victor Koteliansky, Róbert Langer, Daniel G. Anderson

    Published 2014
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  15. 15
    A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    A combinatorial library of lipid-like materials for delivery of RNAi therapeutics by Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg, Elizaveta S. Leshchiner, Valentina Busini, Naushad Hossain, Sergio Bacallado, David N. Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin de Fougerolles, J. Robert Dorkin, K. N. Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir V. Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G. Rajeev, Dinah W.Y. Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans‐Peter Vornlocher, Tracy Zimmermann, Róbert Langer, Daniel G. Anderson

    Published 2008
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