Rezultati - Ismael Al‐Ramahi

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  1. 1
    Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases

    Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases od Joana Branco, Ismael Al‐Ramahi, Lubna Ukani, Alma Perez, Pedro Fernández-Fúnez, Diego E. Rincon‐Limas, Juan Botas

    Izdano 2007
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  2. 2
    TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia

    TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia od Pablo Calap-Quintana, Sirena Soriano, José Vicente Llorens, Ismael Al‐Ramahi, Juan Botas, María Dolores Moltó, M. J. Martínez-Sebastián

    Izdano 2015
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  3. 3
    MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1

    MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1 od María de Haro, Ismael Al‐Ramahi, Béatrice Gouyon, Lubna Ukani, Alberto L. Rosa, Nuno André Faustino, Tetsuo Ashizawa, Thomas A. Cooper, Juan Botas

    Izdano 2006
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  4. 4
    dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1

    dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1 od Ismael Al‐Ramahi, Alma Perez, Janghoo Lim, Minghang Zhang, Rie Sørensen, María de Haro, Joana Branco, Stefan M. Pulst, Huda Y. Zoghbi, Juan Botas

    Izdano 2007
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  5. 5
    Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

    Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain od Dyna Shirasaki, Erin R. Greiner, Ismael Al‐Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H. Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A. Loo, Xia Yang

    Izdano 2012
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  6. 6
    Evolutionarily conserved regulators of tau identify targets for new therapies

    Evolutionarily conserved regulators of tau identify targets for new therapies od Jiyoen Kim, María de Haro, Ismael Al‐Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Y. Zoghbi

    Izdano 2023
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  7. 7
    A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

    A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity od Yuwei Yao, Xiaotian Cui, Ismael Al‐Ramahi, Xiaoli Sun, Bo Li, Jiapeng Hou, Marian DiFiglia, James Palacino, Zhi‐Ying Wu, Lixiang Ma, Juan Botas, Boxun Lu

    Izdano 2015
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  8. 8
    CHIP Protects from the Neurotoxicity of Expanded and Wild-type Ataxin-1 and Promotes Their Ubiquitination and Degradation

    CHIP Protects from the Neurotoxicity of Expanded and Wild-type Ataxin-1 and Promotes Their Ubiquitination and Degradation od Ismael Al‐Ramahi, Yung C. Lam, Hung-Kai Chen, Beatrice de Gouyon, Minghang Zhang, Alma Perez, Joana Branco, María de Haro, Cam Patterson, Huda Y. Zoghbi, Juan Botas

    Izdano 2006
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  9. 9
    TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy

    TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy od George A. Edwards, Caleb A. Wood, Yang He, Quynh Nguyen, Peter J. Kim, Ruben Gomez‐Gutierrez, Kyung Won Park, Yong Xu, Cody Zurhellen, Ismael Al‐Ramahi, Joanna L. Jankowsky

    Izdano 2024
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  10. 10
    Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

    Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease od John P. Miller, Jennifer Holcomb, Ismael Al‐Ramahi, María de Haro, Juliette Gafni, Ningzhe Zhang, Eugene S. Kim, Mario Sanhueza, Cameron Torcassi, Seung Kwak, Juan Botas, Robert E. Hughes, Lisa Ellerby

    Izdano 2010
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  11. 11
    Huntingtin proteolysis releases non‐polyQ fragments that cause toxicity through dynamin 1 dysregulation

    Huntingtin proteolysis releases non‐polyQ fragments that cause toxicity through dynamin 1 dysregulation od Marie‐Thérèse El‐Daher, Emilie Hangen, Julie Bruyère, Ghislaine Poizat, Ismael Al‐Ramahi, Raúl Pardo, Nicolas Bourg, Sylvie Souquère, Céline Mayet, Gérard Pierron, Sandrine Lévêque‐Fort, Juan Botas, Sandrine Humbert, Frédéric Saudou

    Izdano 2015
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  12. 12
    Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease

    Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease od Todd M. Greco, Christopher Secker, Eduardo Silva Ramos, Joel D. Federspiel, Jeh-Ping Liu, Alma Perez, Ismael Al‐Ramahi, Jeffrey P. Cantle, Jeffrey B. Carroll, Juan Botas, Scott Zeitlin, Erich E. Wanker, Ileana M. Cristea

    Izdano 2022
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  13. 13
    Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

    Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity od Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg, Timothy Wu, Tom V. Lee, Yarong Li, Duc M. Duong, Carlos Cruchaga, Carlos Cruchaga, Genevera I. Allen, Nicholas T. Seyfried, Ismael Al‐Ramahi, Juan Botas, Joshua M. Shulman

    Izdano 2023
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  14. 14
    Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson’s disease

    Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson’s disease od Justin Moore, Timothy Wu, Justin Dhindsa, Omar El Fadel, Anh‐Tuan Le, Alma Perez, Bismark K Amoh, Akash Tarkunde, Katy Fan Zhu, Matthew Avalos, Eric B. Dammer, Duc M. Duong, Nicholas T. Seyfried, Joshua M. Shulman, Ismael Al‐Ramahi, Juan Botas

    Izdano 2025
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  15. 15
    TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

    TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau od Maxime W.C. Rousseaux, María de Haro, Cristian A. Lasagna‐Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar‐Nejad, Ismael Al‐Ramahi, Ajay Sharma, Lauren See, Nan Lü, Luis Vilanova-Velez, Tiemo J. Klisch, Thomas F. Westbrook, Juan C. Troncoso, Juan Botas, Huda Y. Zoghbi

    Izdano 2016
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  16. 16
    Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

    Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model od Cristian A. Lasagna‐Reeves, María de Haro, Shuang Hao, Jeehye Park, Maxime W.C. Rousseaux, Ismael Al‐Ramahi, Paymaan Jafar‐Nejad, Luis Vilanova-Velez, Lauren See, Antonia De Maio, Larissa Nitschke, Zhenyu Wu, Juan C. Troncoso, Thomas F. Westbrook, Jianrong Tang, Juan Botas, Huda Y. Zoghbi

    Izdano 2016
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  17. 17
    Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

    Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice od Peter Langfelder, Jeffrey P. Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al‐Ramahi, Xiao‐Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao, Sandeep Deverasetty, Andreas Tebbe, Christoph Schaab, Daniel J. Lavery, David Howland, Seung Kwak, Juan Botas, Jeffrey S. Aaronson, Jim Rosinski, Giovanni Coppola, Steve Horvath, X. William Yang

    Izdano 2016
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  18. 18
    Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

    Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein od Ismael Al‐Ramahi, Sai Srinivas Panapakkam Giridharan, Yu‐Chi Chen, Samarjit Patnaik, Nathaniel Safren, Junya Hasegawa, María de Haro, Amanda K Wagner Gee, Steven A. Titus, Hyunkyung Jeong, Jonathan H. Clarke, Dimitri Krainc, Wei Zheng, Robin F. Irvine, Sami J. Barmada, Marc Ferrer, Noel Southall, Lois S. Weisman, Juan Botas, Juan Marugán

    Izdano 2017
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  19. 19
    RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

    RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1 od Jeehye Park, Ismael Al‐Ramahi, Qiumin Tan, Nissa Mollema, Javier R. Diaz-García, Tatiana Gallego‐Flores, Hsiang-Chih Lu, Sarita Lagalwar, Lisa Duvick, Hyojin Kang, Yoontae Lee, Paymaan Jafar‐Nejad, Layal S. Sayegh, Ronald Richman, Xiuyun Liu, Yan Gao, Chad A. Shaw, J. Simon C. Arthur, Harry T. Orr, Thomas F. Westbrook, Juan Botas, Huda Y. Zoghbi

    Izdano 2013
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  20. 20
    A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach

    A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach od Maxime W.C. Rousseaux, Gabriel E. Vázquez-Vélez, Ismael Al‐Ramahi, Hyun-Hwan Jeong, Aleksandar Bajić, Jean‐Pierre Revelli, Hui Ye, Emily T. Phan, Jennifer Deger, Alma Perez, Ji‐Yoen Kim, Laura A. Lavery, Qikia Xu, Mamie Z. Li, Hyo-Jin Kang, Ji‐Eun Kim, Joshua Shulman, Thomas F. Westbrook, Stephen J. Elledge, Zhandong Liu, Juan Botas, Huda Y. Zoghbi

    Izdano 2018
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