Resultados da busca - Hengyu Lu

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  1. 1
    Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR

    Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR por Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew J. LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai‐Xiang Hao

    Publicado em 2020
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  2. 2
    SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors

    SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors por Hengyu Lu, Chen Liu, Roberto Velazquez, Hongyun Wang, Lukas Manuel Dunkl, Malika Kazic-Legueux, Anne Haberkorn, Éric Billy, Eusebio Manchado, Saskia M. Brachmann, Susan E. Moody, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Morvarid Mohseni, Huai‐Xiang Hao

    Publicado em 2019
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  3. 3
    Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing

    Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing por Lixing Yang, Mi-Sook Lee, Hengyu Lu, Doo‐Yi Oh, Yeon Jeong Kim, Donghyun Park, Gahee Park, Xiaojia Ren, Christopher A. Bristow, Psalm Haseley, Soohyun Lee, Angeliki Pantazi, Raju Kucherlapati, Woong‐Yang Park, Kenneth L. Scott, Yoon‐La Choi, Peter J. Park

    Publicado em 2016
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  4. 4
    RET Fusion as a Novel Driver of Medullary Thyroid Carcinoma

    RET Fusion as a Novel Driver of Medullary Thyroid Carcinoma por Elizabeth G. Grubbs, Patrick Kwok‐Shing Ng, Jacquelin H. Bui, Naifa L. Busaidy, Ken Chen, Jeffrey E. Lee, Xinyan Lu, Hengyu Lu, Funda Meric‐Bernstam, Gordon B. Mills, Gary A. Palmer, Nancy D. Perrier, Kenneth L. Scott, Kenna Shaw, Steven G. Waguespack, Michelle D. Williams, Roman Yelensky, Gilbert J. Cote

    Publicado em 2014
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  5. 5
    In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

    In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer por Caitlin L. Grzeskowiak, Samrat T. Kundu, Xiulei Mo, Andrei A. Ivanov, Oksana Zagorodna, Hengyu Lu, Richard H. Chapple, Yiu Huen Tsang, Daniela Moreno, M. Mosqueda, Karina Eterovic, Jared J. Fradette, S Ahmad, Fengju Chen, Zechen Chong, Ken Chen, Chad J. Creighton, Haian Fu, Gordon B. Mills, Don L. Gibbons, Kenneth L. Scott

    Publicado em 2018
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  6. 6
    Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling

    Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling por Chen Liu, Hengyu Lu, Hongyun Wang, Alice Loo, Xiamei Zhang, Guizhi Yang, Colleen Kowal, Scott Delach, Ye Wang, Silvia Goldoni, William D. Hastings, Karrie Wong, Hui Gao, Matthew J. Meyer, Susan E. Moody, Matthew J. LaMarche, Jeffrey A. Engelman, Juliet Williams, Peter S. Hammerman, Tinya J. Abrams, Morvarid Mohseni, Giordano Caponigro, Huai‐Xiang Hao

    Publicado em 2020
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  7. 7
    Functional annotation of rare gene aberration drivers of pancreatic cancer

    Functional annotation of rare gene aberration drivers of pancreatic cancer por Yiu Huen Tsang, Turgut Dogruluk, Philip M. Tedeschi, Joanna Wardwell‐Ozgo, Hengyu Lu, Maribel Espitia, Nikitha Nair, Rosalba Minelli, Zechen Chong, Fengju Chen, Qing Chang, Jennifer B. Dennison, Armel Dogruluk, Min Li, Haoqiang Ying, Joseph R. Bertino, Marie-Claude Gingras, Michael Ittmann, John E. Kerrigan, Ken Chen, Chad J. Creighton, Karina Eterovic, Gordon B. Mills, Kenneth L. Scott

    Publicado em 2016
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  8. 8
    Dual Allosteric Inhibition of SHP2 Phosphatase

    Dual Allosteric Inhibition of SHP2 Phosphatase por Michelle Fodor, Edmund V. Price, Ping Wang, Hengyu Lu, Andreea Argintaru, Zhouliang Chen, Meir Glick, Huai‐Xiang Hao, Mitsunori Kato, Robert Koenig, Jonathan R. LaRochelle, Gang Liu, Eric McNeill, Dyuti Majumdar, Gisele Nishiguchi, Lawrence Perez, Grégory Paris, Christopher M. Quinn, Timothy M. Ramsey, Martin Sendzik, Michael D. Shultz, Sarah Williams, Travis Stams, Stephen C. Blacklow, Michael Acker, Matthew J. LaMarche

    Publicado em 2018
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  9. 9
    Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers

    Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers por Huai‐Xiang Hao, Hongyun Wang, Chen Liu, Steven Kovats, Roberto Velazquez, Hengyu Lu, Bhavesh Pant, Matthew D. Shirley, Matthew J. Meyer, Minying Pu, Joanne Lim, Michael S. Fleming, LeighAnn Alexander, Ali Farsidjani, Matthew J. LaMarche, Susan E. Moody, Serena J. Silver, Giordano Caponigro, Darrin D. Stuart, Tinya J. Abrams, Peter S. Hammerman, Juliet Williams, Jeffrey A. Engelman, Silvia Goldoni, Morvarid Mohseni

    Publicado em 2019
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  10. 10
    Combined KRAS<sup>G12C</sup>and SOS1 inhibition enhances and extends the anti-tumor response in KRAS<sup>G12C</sup>-driven cancers by addressing intrinsic and acquired resistance

    Combined KRAS<sup>G12C</sup>and SOS1 inhibition enhances and extends the anti-tumor response in KRAS<sup>G12C</sup>-driven cancers by addressing intrinsic and acquired resistance por Venu Thatikonda, Hengyu Lu, Sabine Jurado, Kaja Kostyrko, Christopher A. Bristow, Karin Bosch, Ningping Feng, Sisi Gao, Daniel Gerlach, Michael Gmachl, Simone Lieb, Astrid Jeschko, Annette A. Machado, Ethan D. Marszalek, Mikhila Mahendra, Philipp A. Jaeger, Alexey V. Sorokin, Sandra J. Strauss, Francesca Trapani, Scott Kopetz, Christopher P. Vellano, Mark Petronczki, Norbert Kraut, Timothy P. Heffernan, Joseph R. Marszalek, Mark Pearson, Irene C. Waizenegger, Marco H. Hofmann

    Publicado em 2023
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  11. 11
    Systematic Functional Annotation of Somatic Mutations in Cancer

    Systematic Functional Annotation of Somatic Mutations in Cancer por Patrick Kwok‐Shing Ng, Jun Li, Kang Jin Jeong, Shan Shao, Hu Chen, Yiu Huen Tsang, Sohini Sengupta, Zixing Wang, Venkata Hemanjani Bhavana, Richard Tran, Stephanie Soewito, Darlan Conterno Minussi, Daniela Moreno, Kathleen Kong, Turgut Dogruluk, Hengyu Lu, Jianjiong Gao, Collin Tokheim, Daniel Cui Zhou, Amber M. Johnson, Jia Zeng, Carman K. M. Ip, Zhenlin Ju, Matthew Wester, Shuangxing Yu, Yongsheng Li, Christopher P. Vellano, Nikolaus Schultz, Rachel Karchin, Li Ding, Yiling Lu, Lydia W.T. Cheung, Ken Chen, Kenna Shaw, Funda Meric‐Bernstam, Kenneth L. Scott, S. Stephen Yi, Nidhi Sahni, Han Liang, Gordon B. Mills

    Publicado em 2018
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