Resultats de la cerca - Graham MacLeod

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  1. 1
    A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy

    A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy per Rony Chidiac, Md. Joynal Abedin, Graham MacLeod, Andy Yang, Pierre E. Thibeault, Levi L. Blazer, Jarrett Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S. Sidhu, Harald J. Junge, Stéphane Angers

    Publicat 2021
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  2. 2
    High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

    High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities per Traver Hart, Megha Chandrashekhar, Michael Aregger, Zachary Steinhart, Kevin R. Brown, Graham MacLeod, Monika Mis, Michal Zimmermann, Amélie Fradet‐Turcotte, Song Sun, Patricia Mero, Peter B. Dirks, Sachdev S. Sidhu, Frederick P. Roth, Olivia S. Rissland, Daniel Durocher, Stéphane Angers, Jason Moffat

    Publicat 2015
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  3. 3
    Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells

    Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells per Graham MacLeod, Danielle Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi, Zachary Steinhart, Michelle Kushida, Helen Yu, Fiona J. Coutinho, Florence M.G. Cavalli, Ian J. Restall, Xiaoguang Hao, Traver Hart, H. Artee Luchman, Samuel Weiss, Peter B. Dirks, Stéphane Angers

    Publicat 2019
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  4. 4
    Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

    Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer per Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob M. Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham MacLeod, Ivan Topisirović, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stéphane Angers, Philippe P. Roux

    Publicat 2020
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  5. 5
    Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation

    Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation per Islam E. Elkholi, Amélie Robert, Camille Malouf, Jia Wu, Hellen Kuasne, Stanislav Drápela, Graham MacLeod, Steven Hébert, Alain Pacis, Virginie Calderon, Claudia L. Kleinman, Ana P. Gomes, James V. Alvarez, Julio A. Aguirre‐Ghiso, Morag Park, Stéphane Angers, Jean‐François Côté

    Publicat 2025
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  6. 6
    Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells

    Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells per Nishani Rajakulendran, Katherine Rowland, Hayden Selvadurai, Moloud Ahmadi, Nicole I. Park, Sergey Naumenko, Sonam Dolma, Ryan Ward, Milly So, Lilian Lee, Graham MacLeod, Clarissa C. Pasiliao, Caroline Brandon, Ian D. Clarke, Michael D. Cusimano, Mark Bernstein, Nizar N. Batada, Stéphane Angers, Peter B. Dirks

    Publicat 2019
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  7. 7
    Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

    Functional Enhancers Shape Extrachromosomal Oncogene Amplifications per Andrew R. Morton, Nergiz Doğan, Zachary Faber, Graham MacLeod, Cynthia F. Bartels, Megan Piazza, Kevin Allan, Stephen C. Mack, Xiuxing Wang, Ryan C. Gimple, Qiulian Wu, Brian P. Rubin, Shashirekha Shetty, Stéphane Angers, Peter B. Dirks, Richard Sallari, Mathieu Lupien, Jeremy N. Rich, Peter C. Scacheri

    Publicat 2019
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  8. 8
    Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

    Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival per Paul Guilhamon, Charles Chesnelong, Michelle Kushida, Ana Nikolić, Divya Singhal, Graham MacLeod, Seyed Ali Madani Tonekaboni, Florence M.G. Cavalli, Christopher Arlidge, Nishani Rajakulendran, Naghmeh Rastegar, Xiaoguang Hao, Rozina Hassam, Laura J. Smith, Heather Whetstone, Fiona J. Coutinho, Bettina Nadorp, Katrina Ellestad, H. Artee Luchman, Jennifer A. Chan, Molly S. Shoichet, Michael D. Taylor, Benjamin Haibe‐Kains, Samuel Weiss, Stéphane Angers, Marco Gallo, Peter B. Dirks, Mathieu Lupien

    Publicat 2021
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  9. 9
    PRMT5 is required for full-length<i>HTT</i>expression by repressing multiple proximal intronic polyadenylation sites

    PRMT5 is required for full-length<i>HTT</i>expression by repressing multiple proximal intronic polyadenylation sites per Mona Alqazzaz, Felipe E. Ciamponi, Jolene Caifeng Ho, Maxim I. Maron, Manisha Yadav, Aiden M. Sababi, Graham MacLeod, Moloud Ahmadi, Garrett Bullivant, Vincent Tano, Sarah R. Langley, María Sánchez‐Osuna, Patty Sachamitr, Michelle Kushida, Laura M. Richards, Costanza Ferrari Bardile, Mahmoud A. Pouladi, Trevor J. Pugh, Mike Tyers, Stéphane Angers, Peter B. Dirks, Gary D. Bader, Katlin B. Massirer, Dalia Baršytė-Lovejoy, David Shechter, Rachel Harding, C.H. Arrowsmith, Panagiotis Prinos

    Publicat 2024
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  10. 10
    PRMT5 promotes full-length <i>HTT</i> expression by repressing multiple proximal intronic polyadenylation sites

    PRMT5 promotes full-length <i>HTT</i> expression by repressing multiple proximal intronic polyadenylation sites per Manisha Yadav, Mona Alqazzaz, Felipe E. Ciamponi, Jolene Caifeng Ho, Maxim I. Maron, Aiden M. Sababi, Graham MacLeod, Moloud Ahmadi, Garrett Bullivant, Vincent Tano, Sarah R. Langley, María Sánchez‐Osuna, Patty Sachamitr, Michelle Kushida, Costanza Ferrari Bardile, Mahmoud A. Pouladi, Rebecca Kurtz, Laura M. Richards, Trevor J. Pugh, Mike Tyers, Stéphane Angers, Peter Dirks, Gary D. Bader, Ray Truant, Katlin B. Massirer, Dalia Baršytė-Lovejoy, David Shechter, Rachel Harding, C.H. Arrowsmith, Panagiotis Prinos

    Publicat 2025
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  11. 11
    Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

    Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma per Kulandaimanuvel Antony Michealraj, Sachin Kumar, Leo J.Y. Kim, Florence M.G. Cavalli, David Przelicki, John Wojcik, Alberto Delaidelli, Andrea Bajic, Olivier Saulnier, Graham MacLeod, Ravi N. Vellanki, Maria C. Vladoiu, Paul Guilhamon, Winnie Ong, John J. Y. Lee, Yanqing Jiang, Borja Holgado, Alex Rasnitsyn, Ahmad Malik, Ricky Tsai, Cory Richman, Kyle Juraschka, Joonas Haapasalo, Evan Y. Wang, Pasqualino de Antonellis, Hiromichi Suzuki, Hamza Farooq, Polina Balin, Kaitlin Kharas, Randy Van Ommeren, Olga Sirbu, Avesta Rastan, Stacey Krumholtz, Michelle Ly, Moloud Ahmadi, Geneviève Deblois, Dilakshan Srikanthan, Betty Luu, James Loukides, Xiaochong Wu, Livia Garzia, Vijay Ramaswamy, Evgeny Kanshin, María Sánchez‐Osuna, Ibrahim El-Hamamy, Fiona J. Coutinho, Panagiotis Prinos, Sheila K. Singh, Laura Donovan, Craig Daniels, Daniel Schramek, Mike Tyers, Samuel Weiss, Lincoln Stein, Mathieu Lupien, Bradly G. Wouters, Benjamin A. Garcia, C.H. Arrowsmith, Poul H. Sorensen, Stéphane Angers, Nada Jabado, Peter B. Dirks, Stephen C. Mack, Sameer Agnihotri, Jeremy N. Rich, Michael D. Taylor

    Publicat 2020
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