Resultats de la cerca - Gareth R. Howell

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  1. 1
    The Complex Role of Neuroinflammation in Glaucoma

    The Complex Role of Neuroinflammation in Glaucoma per Ileana Soto, Gareth R. Howell

    Publicat 2014
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  2. 2
    Intrinsic axonal degeneration pathways are critical for glaucomatous damage

    Intrinsic axonal degeneration pathways are critical for glaucomatous damage per Gareth R. Howell, Ileana Soto, Richard T. Libby, Simon W. M. John

    Publicat 2012
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  3. 3
    Toward more predictive genetic mouse models of Alzheimer's disease

    Toward more predictive genetic mouse models of Alzheimer's disease per Kristen D. Onos, Stacey J. Sukoff Rizzo, Gareth R. Howell, Michael Sasner

    Publicat 2015
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  4. 4
    Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease

    Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease per Harriet M. Jackson, Ileana Soto, Leah Graham, Gregory W. Carter, Gareth R. Howell

    Publicat 2013
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  5. 5
    Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma

    Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma per Ryan H. Berry, Juan Qu, Simon W. M. John, Gareth R. Howell, Tatjana Jakobs

    Publicat 2015
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  6. 6
    Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

    Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity per Hongtian Yang, Leah Graham, Alaina M. Reagan, Weronika Grabowska, William Schott, Gareth R. Howell

    Publicat 2019
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  7. 7
    Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data

    Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data per Gareth R. Howell, David O. Walton, Benjamin L. King, Richard T. Libby, Simon W. M. John

    Publicat 2011
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  8. 8
    Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice

    Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice per Gareth R. Howell, Ileana Soto, Margaret M. Ryan, Leah Graham, Richard S. Smith, Simon W. M. John

    Publicat 2013
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  9. 9
    Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

    Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease per Leah Graham, Jeffrey M. Harder, Ileana Soto, Wilhelmine N. de Vries, Simon W. M. John, Gareth R. Howell

    Publicat 2016
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  10. 10
    Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

    Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease per Hongtian Yang, Kristen D. Onos, Kwangbom Choi, Kelly J. Keezer, Daniel A. Skelly, Gregory W. Carter, Gareth R. Howell

    Publicat 2021
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  11. 11
    The APOEε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

    The APOEε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice per Kate E. Foley, Amanda A. Hewes, Dylan Garceau, Kevin P. Kotredes, Gregory W. Carter, Michael Sasner, Gareth R. Howell

    Publicat 2022
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  12. 12
    Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma

    Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma per Cory A. Diemler, Michael MacLean, Sarah E. Heuer, Amanda A. Hewes, Olivia J. Marola, Richard T. Libby, Gareth R. Howell

    Publicat 2024
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  13. 13
    Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

    Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma per Gareth R. Howell, Katharine H. MacNicoll, Catherine Braine, Ileana Soto, Danilo G. Macalinao, Gregory L. Sousa, Simon W. M. John

    Publicat 2014
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  14. 14
    Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma

    Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma per Pete A. Williams, Gareth R. Howell, Jessica M. Barbay, Catherine Braine, Gregory L. Sousa, Simon W. M. John, James P. Morgan

    Publicat 2013
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  15. 15
    Exercise prevents obesity-induced cognitive decline and white matter damage in mice

    Exercise prevents obesity-induced cognitive decline and white matter damage in mice per Leah Graham, Weronika Grabowska, Yoona Chun, Shannon L. Risacher, Vivek M. Philip, Andrew J. Saykin, Stacey J. Sukoff Rizzo, Gareth R. Howell

    Publicat 2019
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  16. 16
    Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1

    Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1 per Gareth R. Howell, Richard T. Libby, Jeffrey K. Marchant, Lawriston A. Wilson, Ioan M Cosma, Richard S. Smith, Michael G. Anderson, Simon W. M. John

    Publicat 2007
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  17. 17
    Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

    Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice per Jeffrey M. Harder, Pete A. Williams, Catherine Braine, Hongtian Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John, Gareth R. Howell

    Publicat 2020
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  18. 18
    APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

    APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction per Ileana Soto, Leah Graham, Hannah J. Richter, Stephen N. Simeone, Jake E. Radell, Weronika Grabowska, William K. Funkhouser, Megan C. Howell, Gareth R. Howell

    Publicat 2015
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  19. 19
    Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

    Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma per Pete A. Williams, James R. Tribble, Keating W. Pepper, Stephen D. Cross, B. Paul Morgan, James P. Morgan, Simon W. M. John, Gareth R. Howell

    Publicat 2016
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  20. 20
    Genetic context modulates aging and degeneration in the murine retina

    Genetic context modulates aging and degeneration in the murine retina per Olivia J. Marola, Michael MacLean, Travis Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

    Publicat 2025
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