Torthaí cuardaigh - Francesca Tonelli

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  1. 1
    Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery

    Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery de réir Cecilia Masiero, Carla Aresi, Antonella Forlino, Francesca Tonelli

    Foilsithe / Cruthaithe 2024
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  2. 2
    Structural basis of human LRRK2 membrane recruitment and activation

    Structural basis of human LRRK2 membrane recruitment and activation de réir Hanwen Zhu, Francesca Tonelli, Dario R. Alessi, Ji Sun

    Foilsithe / Cruthaithe 2022
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  3. 3
    A chemical-genetics approach to study the role of atypical protein kinase C in <i>Drosophila</i>

    A chemical-genetics approach to study the role of atypical protein kinase C in <i>Drosophila</i> de réir Matthew R. Hannaford, Nicolas Loyer, Francesca Tonelli, Martin Zoltner, Jens Januschke

    Foilsithe / Cruthaithe 2019
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  4. 4
    Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes

    Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes de réir Roberta Besio, Chi‐Wing Chow, Francesca Tonelli, Joan C. Marini, Antonella Forlino

    Foilsithe / Cruthaithe 2019
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  5. 5
    Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2

    Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2 de réir Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R. Prescott, Dario R. Alessi, Ji Sun

    Foilsithe / Cruthaithe 2023
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  6. 6
    FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

    FTY720 Analogues as Sphingosine Kinase 1 Inhibitors de réir Keng G. Lim, Francesca Tonelli, Zaiguo Li, Xuequan Lu, Robert Bittman, Susan Pyne, Nigel J. Pyne

    Foilsithe / Cruthaithe 2011
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  7. 7
    Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

    Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites de réir Raja Sekhar Nirujogi, Francesca Tonelli, Matthew Taylor, Paweł Lis, Alexander Zimprich, Esther Sammler, Dario R. Alessi

    Foilsithe / Cruthaithe 2020
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  8. 8
    LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

    LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade de réir Herschel S. Dhekne, Izumi Yanatori, Edmundo G. Vides, Yuriko Sobu, Federico Diez, Francesca Tonelli, Suzanne R. Pfeffer

    Foilsithe / Cruthaithe 2021
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  9. 9
    Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

    Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain de réir Shahzad S. Khan, Yuriko Sobu, Herschel S. Dhekne, Francesca Tonelli, Kerryn Berndsen, Dario R. Alessi, Suzanne R. Pfeffer

    Foilsithe / Cruthaithe 2021
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  10. 10
    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease de réir Shahzad S. Khan, Ebsy Jaimon, Yu‐En Lin, Jonas Nikoloff, Francesca Tonelli, Dario R. Alessi, Suzanne R. Pfeffer

    Foilsithe / Cruthaithe 2024
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  11. 11
    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease de réir Shahzad S. Khan, Ebsy Jaimon, Yu‐En Lin, Jonas Nikoloff, Francesca Tonelli, Dario R. Alessi, Suzanne R. Pfeffer

    Foilsithe / Cruthaithe 2024
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  12. 12
    Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders

    Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders de réir Francesca Tonelli, Jan Willem Bek, Roberta Besio, Adelbert De Clercq, Laura Leoni, Phil Salmon, Paul Coucke, Andy Willaert, Antonella Forlino

    Foilsithe / Cruthaithe 2020
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  13. 13
    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain de réir Herschel S. Dhekne, Izumi Yanatori, Rachel C. Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R. Alessi, Suzanne R. Pfeffer

    Foilsithe / Cruthaithe 2018
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  14. 14
    Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease

    Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease de réir Özge Karayel, Francesca Tonelli, Sebastian Virreira Winter, Philipp E. Geyer, Ying Fan, Esther Sammler, Dario R. Alessi, Martin Steger, Matthias Mann

    Foilsithe / Cruthaithe 2020
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  15. 15
    FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

    FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-inde... de réir Francesca Tonelli, Keng Gat Lim, Carolyn J. Loveridge, Jaclyn S. Long, Stuart M. Pitson, Gábor Tigyi, Robert Bittman, Susan Pyne, Nigel J. Pyne

    Foilsithe / Cruthaithe 2010
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  16. 16
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding de réir Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi

    Foilsithe / Cruthaithe 2022
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  17. 17
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase de réir Herschel S. Dhekne, Francesca Tonelli, Wondwossen M Yeshaw, Claire Y Chiang, Charles Limouse, Ebsy Jaimon, Elena Purlyte, Dario R. Alessi, Suzanne R. Pfeffer

    Foilsithe / Cruthaithe 2023
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  18. 18
    Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure

    Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting... de réir Valentina Daponte, Francesca Tonelli, Cecilia Masiero, Delfien Syx, Chloé Exbrayat-Heritier, Marco Biggiogera, Andy Willaert, Antonio Rossi, Paul Coucke, Florence Ruggiero, Antonella Forlino

    Foilsithe / Cruthaithe 2023
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  19. 19
    Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase

    Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase de réir Elena Purlyte, Herschel S. Dhekne, Adil R. Sarhan, Rachel C. Gomez, Paweł Lis, Melanie Wightman, Terina N. Martinez, Francesca Tonelli, Suzanne R. Pfeffer, Dario R. Alessi

    Foilsithe / Cruthaithe 2017
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  20. 20
    The administration of exogenous HSP47 as a collagen specific therapeutic approach

    The administration of exogenous HSP47 as a collagen specific therapeutic approach de réir Roberta Besio, Nadia Garibaldi, Alessandra Sala, Francesca Tonelli, Carla Aresi, Elisa Maffioli, Claudio Casali, Camilla Torriani, Marco Biggiogera, Simona Villani, Antonio Rossi, Gabriella Tedeschi, Antonella Forlino

    Foilsithe / Cruthaithe 2025
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