Søgeresultater - Francesca Tonelli

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  1. 1
    Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery

    Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery af Cecilia Masiero, Carla Aresi, Antonella Forlino, Francesca Tonelli

    Udgivet 2024
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  2. 2
    Structural basis of human LRRK2 membrane recruitment and activation

    Structural basis of human LRRK2 membrane recruitment and activation af Hanwen Zhu, Francesca Tonelli, Dario R. Alessi, Ji Sun

    Udgivet 2022
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  3. 3
    A chemical-genetics approach to study the role of atypical protein kinase C in <i>Drosophila</i>

    A chemical-genetics approach to study the role of atypical protein kinase C in <i>Drosophila</i> af Matthew R. Hannaford, Nicolas Loyer, Francesca Tonelli, Martin Zoltner, Jens Januschke

    Udgivet 2019
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  4. 4
    Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes

    Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes af Roberta Besio, Chi‐Wing Chow, Francesca Tonelli, Joan C. Marini, Antonella Forlino

    Udgivet 2019
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  5. 5
    Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2

    Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2 af Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R. Prescott, Dario R. Alessi, Ji Sun

    Udgivet 2023
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  6. 6
    FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

    FTY720 Analogues as Sphingosine Kinase 1 Inhibitors af Keng G. Lim, Francesca Tonelli, Zaiguo Li, Xuequan Lu, Robert Bittman, Susan Pyne, Nigel J. Pyne

    Udgivet 2011
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  7. 7
    Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

    Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites af Raja Sekhar Nirujogi, Francesca Tonelli, Matthew Taylor, Paweł Lis, Alexander Zimprich, Esther Sammler, Dario R. Alessi

    Udgivet 2020
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  8. 8
    LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

    LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade af Herschel S. Dhekne, Izumi Yanatori, Edmundo G. Vides, Yuriko Sobu, Federico Diez, Francesca Tonelli, Suzanne R. Pfeffer

    Udgivet 2021
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  9. 9
    Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

    Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain af Shahzad S. Khan, Yuriko Sobu, Herschel S. Dhekne, Francesca Tonelli, Kerryn Berndsen, Dario R. Alessi, Suzanne R. Pfeffer

    Udgivet 2021
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  10. 10
    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease af Shahzad S. Khan, Ebsy Jaimon, Yu‐En Lin, Jonas Nikoloff, Francesca Tonelli, Dario R. Alessi, Suzanne R. Pfeffer

    Udgivet 2024
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  11. 11
    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease af Shahzad S. Khan, Ebsy Jaimon, Yu‐En Lin, Jonas Nikoloff, Francesca Tonelli, Dario R. Alessi, Suzanne R. Pfeffer

    Udgivet 2024
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  12. 12
    Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders

    Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders af Francesca Tonelli, Jan Willem Bek, Roberta Besio, Adelbert De Clercq, Laura Leoni, Phil Salmon, Paul Coucke, Andy Willaert, Antonella Forlino

    Udgivet 2020
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  13. 13
    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain af Herschel S. Dhekne, Izumi Yanatori, Rachel C. Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R. Alessi, Suzanne R. Pfeffer

    Udgivet 2018
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  14. 14
    Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease

    Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease af Özge Karayel, Francesca Tonelli, Sebastian Virreira Winter, Philipp E. Geyer, Ying Fan, Esther Sammler, Dario R. Alessi, Martin Steger, Matthias Mann

    Udgivet 2020
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  15. 15
    FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

    FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-inde... af Francesca Tonelli, Keng Gat Lim, Carolyn J. Loveridge, Jaclyn S. Long, Stuart M. Pitson, Gábor Tigyi, Robert Bittman, Susan Pyne, Nigel J. Pyne

    Udgivet 2010
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  16. 16
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding af Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi

    Udgivet 2022
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  17. 17
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase af Herschel S. Dhekne, Francesca Tonelli, Wondwossen M Yeshaw, Claire Y Chiang, Charles Limouse, Ebsy Jaimon, Elena Purlyte, Dario R. Alessi, Suzanne R. Pfeffer

    Udgivet 2023
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  18. 18
    Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure

    Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting... af Valentina Daponte, Francesca Tonelli, Cecilia Masiero, Delfien Syx, Chloé Exbrayat-Heritier, Marco Biggiogera, Andy Willaert, Antonio Rossi, Paul Coucke, Florence Ruggiero, Antonella Forlino

    Udgivet 2023
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  19. 19
    Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase

    Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase af Elena Purlyte, Herschel S. Dhekne, Adil R. Sarhan, Rachel C. Gomez, Paweł Lis, Melanie Wightman, Terina N. Martinez, Francesca Tonelli, Suzanne R. Pfeffer, Dario R. Alessi

    Udgivet 2017
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  20. 20
    The administration of exogenous HSP47 as a collagen specific therapeutic approach

    The administration of exogenous HSP47 as a collagen specific therapeutic approach af Roberta Besio, Nadia Garibaldi, Alessandra Sala, Francesca Tonelli, Carla Aresi, Elisa Maffioli, Claudio Casali, Camilla Torriani, Marco Biggiogera, Simona Villani, Antonio Rossi, Gabriella Tedeschi, Antonella Forlino

    Udgivet 2025
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