Resultats de la cerca - Douglas M. Fowler

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  1. 1
    Deep mutational scanning: a new style of protein science

    Deep mutational scanning: a new style of protein science per Douglas M. Fowler, Stanley Fields

    Publicat 2014
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  2. 2
    Deep mutational scanning: assessing protein function on a massive scale

    Deep mutational scanning: assessing protein function on a massive scale per Carlos L. Araya, Douglas M. Fowler

    Publicat 2011
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  3. 3
    Will variants of uncertain significance still exist in 2030?

    Will variants of uncertain significance still exist in 2030? per Douglas M. Fowler, Heidi L. Rehm

    Publicat 2023
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  4. 4
    Measuring the activity of protein variants on a large scale using deep mutational scanning

    Measuring the activity of protein variants on a large scale using deep mutational scanning per Douglas M. Fowler, Jason J. Stephany, Stanley Fields

    Publicat 2014
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  5. 5
    Partial Restoration of Mutant Enzyme Homeostasis in Three Distinct Lysosomal Storage Disease Cell Lines by Altering Calcium Homeostasis

    Partial Restoration of Mutant Enzyme Homeostasis in Three Distinct Lysosomal Storage Disease Cell Lines by Altering Calcium Homeostasis per Ting‐Wei Mu, Douglas M. Fowler, Jeffery W. Kelly

    Publicat 2008
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  6. 6
    A platform for functional assessment of large variant libraries in mammalian cells

    A platform for functional assessment of large variant libraries in mammalian cells per Kenneth A. Matreyek, Jason J. Stephany, Douglas M. Fowler

    Publicat 2017
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  7. 7
    Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions

    Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions per Vanessa E. Gray, Ronald J. Hause, Douglas M. Fowler

    Publicat 2017
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  8. 8
    Enrich: software for analysis of protein function by enrichment and depletion of variants

    Enrich: software for analysis of protein function by enrichment and depletion of variants per Douglas M. Fowler, Carlos L. Araya, Wayne Gerard, Stanley Fields

    Publicat 2011
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  9. 9
    Biophysical and Mechanistic Models for Disease-Causing Protein Variants

    Biophysical and Mechanistic Models for Disease-Causing Protein Variants per Amelie Stein, Douglas M. Fowler, Rasmus Hartmann‐Petersen, Kresten Lindorff‐Larsen

    Publicat 2019
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  10. 10
    Pharmacogenomics of CYP2C9: Functional and Clinical Considerations

    Pharmacogenomics of CYP2C9: Functional and Clinical Considerations per Ann K. Daly, Allan E. Rettie, Douglas M. Fowler, John O. Miners

    Publicat 2017
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  11. 11
    Quantitative Missense Variant Effect Prediction Using Large-Scale Mutagenesis Data

    Quantitative Missense Variant Effect Prediction Using Large-Scale Mutagenesis Data per Vanessa E. Gray, Ronald J. Hause, Jens Luebeck, Jay Shendure, Douglas M. Fowler

    Publicat 2017
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  12. 12
    An improved platform for functional assessment of large protein libraries in mammalian cells

    An improved platform for functional assessment of large protein libraries in mammalian cells per Kenneth A. Matreyek, Jason J. Stephany, Melissa A. Chiasson, Nicholas Hasle, Douglas M. Fowler

    Publicat 2019
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  13. 13
    A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

    A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function per Carlos L. Araya, Douglas M. Fowler, Wentao Chen, Ike Muniez, Jeffery W. Kelly, Stanley Fields

    Publicat 2012
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  14. 14
    Functional Amyloid Formation within Mammalian Tissue

    Functional Amyloid Formation within Mammalian Tissue per Douglas M. Fowler, Atanas V. Koulov, Christelle Alory-Jost, Michael S. Marks, William E. Balch, Jeffery W. Kelly

    Publicat 2005
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  15. 15
    A statistical framework for analyzing deep mutational scanning data

    A statistical framework for analyzing deep mutational scanning data per Alan F. Rubin, Hannah Gelman, Nathan Lucas, Sandra Bajjalieh, Anthony T. Papenfuss, Terence P. Speed, Douglas M. Fowler

    Publicat 2017
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  16. 16
    A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

    A chemically controlled Cas9 switch enables temporal modulation of diverse effectors per Cindy T. Wei, Nicholas A. Popp, Omri Peleg, Rachel L. Powell, Elhanan Borenstein, Dustin J. Maly, Douglas M. Fowler

    Publicat 2023
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  17. 17
    The dynamin middle domain is critical for tetramerization and higher-order self-assembly

    The dynamin middle domain is critical for tetramerization and higher-order self-assembly per Rajesh Ramachandran, Mark C. Surka, Joshua S. Chappie, Douglas M. Fowler, Ted R. Foss, Byeong Doo Song, Sandra L. Schmid

    Publicat 2006
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  18. 18
    High-resolution mapping of protein sequence-function relationships

    High-resolution mapping of protein sequence-function relationships per Douglas M. Fowler, Carlos L. Araya, Sarel J. Fleishman, Elizabeth H. Kellogg, Jason J. Stephany, David Baker, Stanley Fields

    Publicat 2010
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  19. 19
    MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect

    MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect per Daniel Esposito, Jochen Weile, Jay Shendure, Lea M. Starita, Anthony T. Papenfuss, Frederick P. Roth, Douglas M. Fowler, Alan F. Rubin

    Publicat 2019
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  20. 20
    Systematic misclassification of missense variants in BRCA1 and BRCA2 “coldspots”

    Systematic misclassification of missense variants in BRCA1 and BRCA2 “coldspots” per Jennifer N. Dines, Brian H. Shirts, Thomas P. Slavin, Tom Walsh, Mary‐Claire King, Douglas M. Fowler, Colin C. Pritchard

    Publicat 2020
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