Search Results - Denzil Bernard

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  1. 1
    Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics

    Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics by Yujun Zhao, Denzil Bernard, Shaomeng Wang

    Published 2013
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  2. 2
    Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

    Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment by Yujun Zhao, Angelo Aguilar, Denzil Bernard, Shaomeng Wang

    Published 2014
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  3. 3
    Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction

    Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction by Hacer Karataş, Elizabeth C. Townsend, Denzil Bernard, Yali Dou, Shaomeng Wang

    Published 2010
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  4. 4
    Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges

    Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges by Shaomeng Wang, Yujun Zhao, Angelo Aguilar, Denzil Bernard, Chao‐Yie Yang

    Published 2017
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  5. 5
    Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

    Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors by Jianyong Chen, Longchuan Bai, Denzil Bernard, Zaneta Nikolovska‐Coleska, Cindy Gomez, Jian Zhang, Yi Han, Shaomeng Wang

    Published 2010
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  6. 6
    Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

    Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles by Angelo Aguilar, Wei Sun, Liu Liu, Jianfeng Lu, Donna McEachern, Denzil Bernard, Jeffrey R. Deschamps, Shaomeng Wang

    Published 2014
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  7. 7
    High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

    High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction by Hacer Karataş, Elizabeth C. Townsend, Fang Cao, Yong Chen, Denzil Bernard, Liu Liu, Ming Lei, Yali Dou, Shaomeng Wang

    Published 2012
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  8. 8
    A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

    A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice by Yujun Zhao, Shanghai Yu, Wei Sun, Liu Liu, Jianfeng Lü, Donna McEachern, Sanjeev Shargary, Denzil Bernard, Xiaoqin Li, Ting Zhao, Peng Zou, Duxin Sun, Shaomeng Wang

    Published 2013
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  9. 9
    Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma

    Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma by Zhang Xiao Ying, Meiyan Jin, Luke F. Peterson, Denzil Bernard, Kamlai Saiya-Cork, Mehmet Ali Yıldız, Shaomeng Wang, Mark Kaminski, Alfred E. Chang, Daniel J. Klionsky, Sami N. Malek

    Published 2016
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  10. 10
    Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

    Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors by Yujun Zhao, Liu Liu, Wei Sun, Jianfeng Lü, Donna McEachern, Xiaoqin Li, Shanghai Yu, Denzil Bernard, Philippe Ochsenbein, Vincent Ferey, Jean‐Christophe Carry, Jeffrey R. Deschamps, Duxin Sun, Shaomeng Wang

    Published 2013
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  11. 11
    Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

    Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer by Sanjeev Shangary, Ke Ding, Su Qiu, Zaneta Nikolovska‐Coleska, Joshua A. Bauer, Meilan Liu, Guoping Wang, Yipin Lu, Donna McEachern, Denzil Bernard, Carol R. Bradford, Thomas E. Carey, Shaomeng Wang

    Published 2008
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  12. 12
    High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction

    High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction by Haibin Zhou, Weihua Zhou, Bing Zhou, Liu Liu, Ting‐Rong Chern, Krishnapriya Chinnaswamy, Jianfeng Lü, Denzil Bernard, Chao‐Yie Yang, Shasha Li, Mi Wang, Jeanne A. Stuckey, Yi Sun, Shaomeng Wang

    Published 2018
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  13. 13
    Activating STAT6 mutations in follicular lymphoma

    Activating STAT6 mutations in follicular lymphoma by Mehmet Ali Yıldız, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Siân Jones, Kamlai Saiya-Cork, Brian Parkin, Kathryn Jacobi, Kerby Shedden, Shaomeng Wang, Alfred E. Chang, Mark Kaminski, Sami N. Malek

    Published 2014
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  14. 14
    A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

    A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation by Haibin Zhou, Jianfeng Lü, Liu Liu, Denzil Bernard, Chao-Yie Yang, Ester Fernández‐Salas, Krishnapriya Chinnaswamy, Stephanie Danielle Layton, Jeanne A. Stuckey, Qing Yu, Weihua Zhou, Zhen‐Qiang Pan, Yi Sun, Shaomeng Wang

    Published 2017
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  15. 15
    Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction

    Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction by Shilin Xu, Angelo Aguilar, Tianfeng Xu, Ke Zheng, Liyue Huang, Jeanne A. Stuckey, Krishnapriya Chinnaswamy, Denzil Bernard, Ester Fernández‐Salas, Liu Liu, Mi Wang, Donna McEachern, Sally Przybranowski, C.L. Foster, Shaomeng Wang

    Published 2017
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  16. 16
    Discovery of 4-((3′<i>R</i>,4′<i>S</i>,5′<i>R</i>)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

    Discovery of 4-((3′<i>R</i>,4′<i>S</i>,5′<i>R</i>)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo... by Angelo Aguilar, Jianfeng Lü, Liu Liu, Ding Du, Denzil Bernard, Donna McEachern, Sally Przybranowski, Xiaoqin Li, Ruijuan Luo, Bo Wen, Duxin Sun, Hengbang Wang, Jianfeng Wen, Guangfeng Wang, Yifan Zhai, Ming Guo, Dajun Yang, Shaomeng Wang

    Published 2017
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  17. 17
    Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

    Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition by Sanjeev Shangary, Dongguang Qin, Donna McEachern, Meilan Liu, Rebecca S. Miller, Su Qiu, Zaneta Nikolovska‐Coleska, Ke Ding, Guoping Wang, Jianyong Chen, Denzil Bernard, Jian Zhang, Yipin Lu, Qingyang Gu, Rajal B. Shah, Kenneth J. Pienta, Xiaolan Ling, Sunghyun Kang, Ming Guo, Yi Sun, Dajun Yang, Shaomeng Wang

    Published 2008
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  18. 18
    SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression

    SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression by Shaomeng Wang, Wei Sun, Yujun Zhao, Donna McEachern, Isabelle Meaux, Cédric Barrière, Jeanne A. Stuckey, Jennifer L. Meagher, Longchuan Bai, Liu Liu, C. Gianna Hoffman-Luca, Jianfeng Lü, Sanjeev Shangary, Shanghai Yu, Denzil Bernard, Angelo Aguilar, Odette Dos-Santos, Laurent Besret, S. Guérif, Pascal Pannier, Dimitri Gorge-Bernat, Laurent Debüssche

    Published 2014
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