Resultats de la cerca - David E. Root

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  1. 1
    Resources for the design of CRISPR gene editing experiments

    Resources for the design of CRISPR gene editing experiments per Daniel B. Graham, David E. Root

    Publicat 2015
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  2. 2
    Identification of an oncogenic RAB protein

    Identification of an oncogenic RAB protein per Douglas B. Wheeler, Roberto Zoncu, David E. Root, David M. Sabatini, Charles L. Sawyers

    Publicat 2015
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  3. 3
    Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors

    Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors per Steven R. Whittaker, Glenn S. Cowley, Steve Wagner, Flora Luo, David E. Root, Levi A. Garraway

    Publicat 2015
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  4. 4
    Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines

    Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines per Joshua M. Dempster, Jordan Rossen, Mariya Kazachkova, Joshua Pan, Guillaume Kugener, David E. Root, Aviad Tsherniak

    Publicat 2019
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  5. 5
    Conserved pathways within bacteria and yeast as revealed by global protein network alignment

    Conserved pathways within bacteria and yeast as revealed by global protein network alignment per Brian Kelley, Roded Sharan, Richard M. Karp, Taylor Sittler, David E. Root, Brent R. Stockwell, Trey Ideker

    Publicat 2003
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  6. 6
    Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression

    Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression per Vishal M. Gohil, Roland Nilsson, Casey A. Belcher-Timme, Biao Luo, David E. Root, Vamsi K. Mootha

    Publicat 2010
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  7. 7
    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool per Katherine Donovan, Mudra Hegde, Meagan E. Sullender, Emma W Vaimberg, Cory M. Johannessen, David E. Root, John G. Doench

    Publicat 2017
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  8. 8
    Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

    Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks per Joel P. Wagner, Alejandro Wolf‐Yadlin, Mark Sevecka, Jennifer K. Grenier, David E. Root, Douglas A. Lauffenburger, Gavin MacBeath

    Publicat 2013
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  9. 9
    A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

    A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation per Jason D. Arroyo, Alexis A. Jourdain, Sarah E. Calvo, Carmine Ballarano, John G. Doench, David E. Root, Vamsi K. Mootha

    Publicat 2016
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  10. 10
    Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

    Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression per Joseph Rosenbluh, Han Xu, William F. Harrington, Stanley Gill, Xiaoxing Wang, Francisca Vázquez, David E. Root, Aviad Tsherniak, William C. Hahn

    Publicat 2017
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  11. 11
    Chronos: a CRISPR cell population dynamics model

    Chronos: a CRISPR cell population dynamics model per Joshua M. Dempster, Isabella Boyle, Francisca Vázquez, David E. Root, Jesse S. Boehm, William C. Hahn, Aviad Tsherniak, James M. McFarland

    Publicat 2021
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  12. 12
    Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

    Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects per Joshua M. Dempster, Isabella Boyle, Francisca Vázquez, David E. Root, Jesse S. Boehm, William C. Hahn, Aviad Tsherniak, James M. McFarland

    Publicat 2021
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  13. 13
    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects per Shantanu Singh, Xiaoyun Wu, Vebjorn Ljosa, Mark‐Anthony Bray, Federica Piccioni, David E. Root, John G. Doench, Jesse S. Boehm, Anne E. Carpenter

    Publicat 2015
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  14. 14
    A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition

    A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition per Steven R. Whittaker, Jean‐Philippe Theurillat, Eliezer M. Van Allen, Nikhil Wagle, Jessica Hsiao, Glenn S. Cowley, Dirk Schadendorf, David E. Root, Levi A. Garraway

    Publicat 2013
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  15. 15
    High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

    High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons per Thomas J.F. Nieland, David J. Logan, Jessica L. Saulnier, Daniel D. Lam, Caroline A. Johnson, David E. Root, Anne E. Carpenter, Bernardo L. Sabatini

    Publicat 2014
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  16. 16
    Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

    Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells per Ophir Shalem, Neville E. Sanjana, Ella Hartenian, Xi Shi, David Scott, Tarjei S. Mikkelsen, Dirk Heckl, Benjamin L. Ebert, David E. Root, John G. Doench, Feng Zhang

    Publicat 2013
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  17. 17
    Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

    Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways per Michelle Dang, Nicole Armbruster, Miles A. Miller, Efraín A. Cermeño, Monika Hartmann, George W. Bell, David E. Root, Douglas A. Lauffenburger, Harvey F. Lodish, Andreas Herrlich

    Publicat 2013
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  18. 18
    CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines

    CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines per Daniel J. Merk, Linda Paul, Foteini Tsiami, Helen Hohenthanner, Ghazal Mohseni Kouchesfahani, Lara A. Haeusser, Bianca Walter, Adam Brown, Nicole S. Persky, David E. Root, Ghazaleh Tabatabai

    Publicat 2024
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  19. 19
    An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

    An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription per Matthieu Giraud, Nada Jmari, Lina Du, Floriane Carallis, Thomas J.F. Nieland, Flor M. Pérez-Campo, Olivier Bensaude, David E. Root, Nir Hacohen, Diane Mathis, Christophe Benoist

    Publicat 2014
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  20. 20
    Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

    Identification of RPS14 as a 5q- syndrome gene by RNA interference screen per Benjamin L. Ebert, Jennifer Pretz, Jocelyn Bosco, Cindy Chang, Pablo Tamayo, Naomi Galili, Azra Raza, David E. Root, Eyal C. Attar, Steven R. Ellis, Todd R. Golub

    Publicat 2008
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