Search Results - Daniel Rauh

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  1. 1
    Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer

    Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer by Julian Engel, Jonas Lategahn, Daniel Rauh

    Published 2015
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  2. 2
    C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

    C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer? by Tobias Grabe, Jonas Lategahn, Daniel Rauh

    Published 2018
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  3. 3
    Spotlight on AKT: Current Therapeutic Challenges

    Spotlight on AKT: Current Therapeutic Challenges by Ina Landel, Lena Quambusch, Laura Depta, Daniel Rauh

    Published 2020
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  4. 4
    KRasG12C inhibitors in clinical trials: a short historical perspective

    KRasG12C inhibitors in clinical trials: a short historical perspective by Lisa Goebel, Matthias Müller, Roger S. Goody, Daniel Rauh

    Published 2020
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  5. 5
    Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase

    Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase by Raynard L. Bateman, Daniel Rauh, Brandon Tavshanjian, Kevan M. Shokat

    Published 2008
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  6. 6
    Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands

    Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands by Janina Niggenaber, Leonie Heyden, Tobias Grabe, Matthias Müller, Jonas Lategahn, Daniel Rauh

    Published 2020
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  7. 7
    Proteus in the World of Proteins: Conformational Changes in Protein Kinases

    Proteus in the World of Proteins: Conformational Changes in Protein Kinases by Matthias Rabiller, Matthäus Getlik, Sabine Klüter, André Richters, Sandra Tückmantel, Jeffrey R. Simard, Daniel Rauh

    Published 2010
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  8. 8
    Identification and Further Development of Potent TBK1 Inhibitors

    Identification and Further Development of Potent TBK1 Inhibitors by André Richters, Debjit Basu, Julian Engel, Meryem S. Ercanoglu, Hyatt Balke‐Want, Roberta Tesch, Roman K. Thomas, Daniel Rauh

    Published 2014
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  9. 9
    Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes

    Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes by Andrey P. Antonchick, S. López-Tosco, Juan A. Parga, Sonja Sievers, Markus Schürmann, Hans Preut, Susanne Höing, Hans R. Schöler, Jared Sterneckert, Daniel Rauh, Herbert Waldmann

    Published 2013
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  10. 10
    An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules

    An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules by Masahiro Tanaka, Raynard L. Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C. Hansen, Alma L. Burlingame, J. K. Trautman, Kevan M. Shokat, Cynthia L. Adams

    Published 2005
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  11. 11
    A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives

    A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives by Daniel N. do Amaral, Jonas Lategahn, Harold Hilarion Fokoue, Eduardo Miguez Bastos da Silva, Carlos Maurício R. Sant’Anna, Daniel Rauh, Eliezer J. Barreiro, Stefan Laufer, Lı́dia Moreira Lima

    Published 2019
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  12. 12
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA by Alina Teuber, Tom Schulz, B. S. Fletcher, Rajesh Gontla, Thomas Mühlenberg, Mia‐Lisa Zischinsky, Janina Niggenaber, Jörn Weisner, Silke Kleinbölting, Jonas Lategahn, Sonja Sievers, Matthias Müller, Sebastian Bauer, Daniel Rauh

    Published 2024
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  13. 13
    ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors

    ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors by Johannes M. Heuckmann, Michael Hölzel, Martin L. Sos, Stefanie Heynck, Hyatt Balke‐Want, Mirjam Koker, Martin Peifer, Jonathan M. Weiss, Christine M. Lovly, Christian Grütter, Daniel Rauh, William Pao, Roman K. Thomas

    Published 2011
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  14. 14
    Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

    Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34 by Lucas Robke, Luca Laraia, Marjorie A. Carnero Corrales, Georgios Konstantinidis, Makoto Muroi, André Richters, Michael Winzker, Tobias Engbring, Stefano Tomassi, Nobumoto Watanabe, Hiroyuki Osada, Daniel Rauh, Herbert Waldmann, Yao‐Wen Wu, Julian Engel

    Published 2017
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  15. 15
    Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt

    Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt by Niklas Uhlenbrock, Steven P. Smith, Jörn Weisner, Ina Landel, Marius Lindemann, Thien Anh Le, Julia Hardick, Rajesh Gontla, Rebekka Scheinpflug, Paul Czodrowski, Petra Janning, Laura Depta, Lena Quambusch, Matthias Müller, Bernd Engels, Daniel Rauh

    Published 2019
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  16. 16
    Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

    Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer by Sampurna Chatterjee, Lukas C. Heukamp, Maike Siobal, Jakob Schöttle, Caroline Wieczorek, Martin Peifer, Davide Frasca, Mirjam Koker, Katharina König, Lydia Meder, Daniel Rauh, Reinhard Buettner, Jürgen Wolf, Rolf A. Brekken, Bernd Neumaier, Gerhard Christofori, Roman K. Thomas, Roland T. Ullrich

    Published 2013
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  17. 17
    Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain

    Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain by Susanne Grünewald, Lillian R. Klug, Thomas Mühlenberg, Jonas Lategahn, Johanna Falkenhorst, Ajia Town, Christiane Ehrt, Eva Wardelmann, Wolfgang Hartmann, Hans‐Ulrich Schildhaus, Juergen Treckmann, Jonathan A. Fletcher, Sascha Jung, Paul Czodrowski, Steven P. Miller, Oleg Schmidt-Kittler, Daniel Rauh, Michael C. Heinrich, Sebastian Bauer

    Published 2020
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  18. 18
    Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation

    Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation by Martin L. Sos, Haridas B. Rode, Stefanie Heynck, Martin Peifer, Florian Fischer, Sabine Klüter, Vijaykumar G. Pawar, Cecile Reuter, Johannes M. Heuckmann, Jonathan M. Weiss, Lars Ruddigkeit, Matthias Rabiller, Mirjam Koker, Jeffrey R. Simard, Matthäus Getlik, Yuki Yuza, Tzu-Hsiu Chen, Heidi Greulich, Roman K. Thomas, Daniel Rauh

    Published 2010
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  19. 19
    A framework for identification of actionable cancer genome dependencies in small cell lung cancer

    A framework for identification of actionable cancer genome dependencies in small cell lung cancer by Martin L. Sos, Felix Dietlein, Martin Peifer, Jakob Schöttle, Hyatt Balke‐Want, Christian Müller, Mirjam Koker, André Richters, Stefanie Heynck, Florian Malchers, Johannes M. Heuckmann, Danila Seidel, Patrick A. Eyers, Roland T. Ullrich, Andrey P. Antonchick, Viktor V. Vintonyak, Peter M. Schneider, Takashi Ninomiya, Herbert Waldmann, Reinhard Büttner, Daniel Rauh, Lukas C. Heukamp, Roman K. Thomas

    Published 2012
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  20. 20
    A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

    A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer by Felix Dietlein, Bastian Kalb, Mladen Jokić, Elisa M. Noll, Alexander Strong, Lars Tharun, Luka Ozretić, Helen Künstlinger, Kato Kambartel, Winfried Randerath, Christian Jüngst, Anna Schmitt, Alessandro Torgovnick, André Richters, Daniel Rauh, Florian Siedek, Thorsten Persigehl, Cornelia Mauch, Jiřina Bártková, Allan Bradley, Martin R. Sprick, Andreas Trumpp, Roland Rad, Dieter Saur, Jiří Bártek, Jürgen Wolf, Reinhard Büttner, Roman K. Thomas, Hans Christian Reinhardt

    Published 2015
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