Resultados da busca - Christine Lukacs

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  1. 1
    Systematic literature review and meta-analysis on the epidemiology of methylmalonic acidemia (MMA) with a focus on MMA caused by methylmalonyl-CoA mutase (mut) deficiency

    Systematic literature review and meta-analysis on the epidemiology of methylmalonic acidemia (MMA) with a focus on MMA caused by methylmalonyl-CoA mutase (mut) deficiency por Tímea Almási, Lin T. Guey, Christine Lukacs, Kata Csetneki, Zoltán Vokó, Tamás Zelei

    Publicado em 2019
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  2. 2
    Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor

    Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor por David C. Fry, Charles Wartchow, Bradford Graves, Cheryl A. Janson, Christine Lukacs, U. Kammlott, Charles Belunis, Stefan Palme, Christian Klein, Binh Thanh Vu

    Publicado em 2013
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  3. 3
    Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia

    Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia por An Ding, Andrea Frassetto, Eric Jacquinet, Marianne Eybye, Joseph Milano, Christine DeAntonis, Vi Nguyen, Rodrigo Laureano, Jaclyn Milton, Staci Sabnis, Christine Lukacs, Lin T. Guey

    Publicado em 2019
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  4. 4
    High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

    High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein por Klaus Klumpp, Angela M. Lam, Christine Lukacs, Robert Vogel, Suping Ren, Christine Espiritu, Ruth Baydo, Kateri Atkins, Jan Abendroth, Guochun Liao, Andrey Efimov, George D. Hartman, Osvaldo Flores

    Publicado em 2015
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  5. 5
    Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

    Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors por Piro Lito, Anna Saborowski, Jingyin Yue, Martha Solomon, Eric W. Joseph, Sunyana Gadal, Michael Saborowski, Edward R. Kastenhuber, Christof Fellmann, Kazuhiro Ohara, Kenji Morikami, Takaaki Miura, Christine Lukacs, Nobuya Ishii, Scott W. Lowe, Neal Rosen

    Publicado em 2014
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  6. 6
    Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

    Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization por Bradford Graves, Thelma Thompson, Mingxuan Xia, Cheryl A. Janson, Christine Lukacs, Dayanand Deo, Paola Di Lello, David C. Fry, Colin W. Garvie, Kuo‐Sen Huang, Lin Gao, Christian Tovar, Allen Lovey, Jutta Wanner, Lyubomir T. Vassilev

    Publicado em 2012
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  7. 7
    Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates

    Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates por Xuling Zhu, Ling Yin, Matt Theisen, Jenny Zhuo, Summar Siddiqui, Becca R. Levy, Vladimir Presnyak, Andrea Frassetto, Jaclyn Milton, Timothy Salerno, Kerry E. Benenato, Joe Milano, Andy Lynn, Staci Sabnis, Kristine Burke, Gilles Besin, Christine Lukacs, Lin T. Guey, Patrick F. Finn, Paolo G.V. Martini

    Publicado em 2019
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  8. 8
    Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy

    Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: im... por Cheng Liao, Jonathan Hsu, Yong Kim, Dong‐Qing Hu, Daigen Xu, Jun Zhang, Achal Pashine, John G. Menke, Toni Whittard, Natasha Romero, Theresa Truitt, Michelle Slade, Christine Lukacs, Johannes C. Hermann, Mingyan Zhou, Matthew C. Lucas, Satwant K. Narula, Julie A. DeMartino, Seng‐Lai Tan

    Publicado em 2013
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  9. 9
    Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia

    Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia por Lei Jiang, Ji-Sun Park, Ling Yin, Rodrigo Laureano, Eric Jacquinet, Jin‐Song Yang, Shi Liang, Andrea Frassetto, Jenny Zhuo, Xinhua Yan, Xuling Zhu, Steven Fortucci, Kara M. Hoar, Cosmin Mihai, Christopher Tunkey, Vladimir Presnyak, Kerry E. Benenato, Christine Lukacs, Paolo G.V. Martini, Lin T. Guey

    Publicado em 2020
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  10. 10
    Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4 mouse model of PFIC3

    Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4 mouse model of PFIC3 por Guangyan Wei, Jingsong Cao, Pinzhu Huang, Ping An, Disha Badlani, Kahini A. Vaid, Shuangshuang Zhao, David Q.‐H. Wang, Jenny Zhuo, Ling Yin, Andrea Frassetto, Arianna Markel, Vladimir Presnyak, Srujan Gandham, Serenus Hua, Christine Lukacs, Patrick F. Finn, Paloma H. Giangrande, Paolo G.V. Martini, Yury Popov

    Publicado em 2020
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  11. 11
    Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

    Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia por An Ding, Jessica L. Schneller, Andrea Frassetto, Shi Liang, Xuling Zhu, Ji-Sun Park, Matt Theisen, Sue‐Jean Hong, Jenny Zhou, Raj Rajendran, Becca R. Levy, Rebecca Howell, Gilles Besin, Vladimir Presnyak, Staci Sabnis, Kerry E. Murphy-Benenato, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai, Christine Lukacs, Randy J. Chandler, Lin T. Guey, Charles P. Venditti, Paolo G.V. Martini

    Publicado em 2017
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  12. 12
    mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency

    mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency por Jingsong Cao, An Ding, Mikel Galduroz, Jenny Zhuo, Shi Liang, Marianne Eybye, Andrea Frassetto, Eishi Kuroda, Aki Funahashi, Jordan Santana, Cosmin Mihai, Kerry E. Benenato, E. Sathyajith Kumarasinghe, Staci Sabnis, Timothy Salerno, Kimberly A. Coughlan, Edward J. Miracco, Becca R. Levy, Gilles Besin, Joshua R. Schultz, Christine Lukacs, Lin T. Guey, Patrick F. Finn, Tatsuhiko Furukawa, Paloma H. Giangrande, Takeyori Saheki, Paolo G.V. Martini

    Publicado em 2019
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  13. 13
    Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

    Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH) por Ganesha Rai, Kyle R. Brimacombe, Bryan T. Mott, Daniel J. Urban, Xin Hu, Shyh‐Ming Yang, Tobie D. Lee, Dorian M. Cheff, Jennifer Kouznetsova, Gloria A. Benavides, Katie Pohida, Eric J. Kuenstner, Diane K. Luci, Christine Lukacs, D.R. Davies, David M. Dranow, Hu Zhu, Gary A. Sulikowski, William Moore, Gordon M. Stott, Andrew Flint, Matthew D. Hall, Victor Darley‐Usmar, Leonard Μ. Neckers, Chi V. Dang, Alex G. Waterson, Anton Simeonov, Ajit Jadhav, David J. Maloney

    Publicado em 2017
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