Ngā hua rapu - Chloe E. Emerson
- E whakaatu ana i te 1 - 2 hua o te 2
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1
mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors mā Clare F. Malone, Chloe E. Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin Liu, Franziska Michor, Marcia C. Haigis, Kay F. Macleod, Ophélia Maertens, Karen Cichowski
I whakaputaina 2017Artigo -
2
MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in <i>BRAF-, NRAS</i>-, and <i>NF1</i>-Mutant Melanomas mā Ophélia Maertens, Ryan Kuzmickas, Haley E. Manchester, Chloe E. Emerson, Alessandra G. Gavin, Caroline J. Guild, Terence C. Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi A. Garraway, Keith T. Flaherty, Shailja Pathania, Stephen J. Elledge, Karen Cichowski
I whakaputaina 2019Artigo
Ngā utauta rapu:
Ngā marau whai pānga
Biology
Cancer research
Genetics
KRAS
Signal transduction
Biochemistry
Cancer
Cell biology
Colorectal cancer
DNA
DNA damage
DNA repair
Gene
HDAC3
Histone
Histone deacetylase
MAPK/ERK pathway
MEK inhibitor
Melanoma
Mutant
Mutation
Neuroblastoma RAS viral oncogene homolog
Oxidative stress
PI3K/AKT/mTOR pathway
Synthetic lethality
TXNIP
Thioredoxin