Torthaí cuardaigh - Chloe E. Emerson
- 1 - 2 toradh as 2 á dtaispeáint
-
1
mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors de réir Clare F. Malone, Chloe E. Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin Liu, Franziska Michor, Marcia C. Haigis, Kay F. Macleod, Ophélia Maertens, Karen Cichowski
Foilsithe / Cruthaithe 2017Artigo -
2
MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in <i>BRAF-, NRAS</i>-, and <i>NF1</i>-Mutant Melanomas de réir Ophélia Maertens, Ryan Kuzmickas, Haley E. Manchester, Chloe E. Emerson, Alessandra G. Gavin, Caroline J. Guild, Terence C. Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi A. Garraway, Keith T. Flaherty, Shailja Pathania, Stephen J. Elledge, Karen Cichowski
Foilsithe / Cruthaithe 2019Artigo
Uirlisí cuardaigh:
Ábhair a bhaineann le hábhar
Biology
Cancer research
Genetics
KRAS
Signal transduction
Biochemistry
Cancer
Cell biology
Colorectal cancer
DNA
DNA damage
DNA repair
Gene
HDAC3
Histone
Histone deacetylase
MAPK/ERK pathway
MEK inhibitor
Melanoma
Mutant
Mutation
Neuroblastoma RAS viral oncogene homolog
Oxidative stress
PI3K/AKT/mTOR pathway
Synthetic lethality
TXNIP
Thioredoxin