检索结果 - Benjamin P. Kleinstiver

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  1. 1
    Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

    Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 由 Russell T. Walton, Kathleen A. Christie, Madelynn N. Whittaker, Benjamin P. Kleinstiver

    出版 2020
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  2. 2
    Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA

    Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA 由 Russell T. Walton, Jonathan Y. Hsu, J. Keith Joung, Benjamin P. Kleinstiver

    出版 2021
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  3. 3
    731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects

    731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects 由 Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew, Shengdar Q. Tsai, Nathalie T. Nguyen, J. Keith Joung

    出版 2016
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  4. 4
    Monomeric site-specific nucleases for genome editing

    Monomeric site-specific nucleases for genome editing 由 Benjamin P. Kleinstiver, Jason M. Wolfs, Tomasz Kolaczyk, Alanna K. Roberts, Sherry X. Hu, David R. Edgell

    出版 2012
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  5. 5
    High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

    High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects 由 Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew, Shengdar Q. Tsai, Nathalie T. Nguyen, Zongli Zheng, J. Keith Joung

    出版 2016
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  6. 6
    Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer

    Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer 由 Caroline Mahendra, Kathleen A. Christie, Beatriz A. Osuna, Rafael Pinilla‐Redondo, Benjamin P. Kleinstiver, Joseph Bondy‐Denomy

    出版 2020
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  7. 7
    Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

    Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells 由 Florian Wünnemann, Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P. Kleinstiver, Guillaume Lettre

    出版 2023
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  8. 8
    Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

    Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition 由 Benjamin P. Kleinstiver, Michelle S. Prew, Shengdar Q. Tsai, Nathalie T. Nguyen, Ved V. Topkar, Zongli Zheng, J. Keith Joung

    出版 2015
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  9. 9
    Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

    Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases 由 Joana Ferreira da Silva, Connor J. Tou, Emily M. King, Madeline L. Eller, Linyuan Ma, David Rufino‐Ramos, Benjamin P. Kleinstiver

    出版 2023
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  10. 10
    Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors

    Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors 由 Y. Esther Tak, Benjamin P. Kleinstiver, James K. Nuñez, Jonathan Y. Hsu, Joy E. Horng, Jingyi Gong, Jonathan S. Weissman, J. Keith Joung

    出版 2017
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  11. 11
    Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa

    Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa 由 Pingjuan Li, Benjamin P. Kleinstiver, Mihoko Leon, Michelle S. Prew, Daniel Navarro-Gomez, Scott H. Greenwald, Eric A. Pierce, J. Keith Joung, Qin Liu

    出版 2018
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  12. 12
    Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes

    Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes 由 Beatriz A. Osuna, Shweta Karambelkar, Caroline Mahendra, Kathleen A. Christie, Bianca Garcı́a, Alan R. Davidson, Benjamin P. Kleinstiver, Samuel Kilcher, Joseph Bondy‐Denomy

    出版 2020
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  13. 13
    Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

    Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells 由 Benjamin P. Kleinstiver, Shengdar Q. Tsai, Michelle S. Prew, Nathalie T. Nguyen, Moira M. Welch, Jose M. Lopez, Zachary R. McCaw, Martin J. Aryee, J. Keith Joung

    出版 2016
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  14. 14
    Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

    Enhanced proofreading governs CRISPR–Cas9 targeting accuracy 由 Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Alexander A. Sousa, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yıldız, Jennifer A. Doudna

    出版 2017
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  15. 15
    Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs

    Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs 由 Jennifer Listgarten, Michael M. Weinstein, Benjamin P. Kleinstiver, Alexander A. Sousa, J. Keith Joung, Jake Crawford, Kevin Gao, Luong Hoang, Melih Elibol, John G. Doench, Nicolò Fusi

    出版 2018
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  16. 16
    CRISPR-Cas knockout of miR21 reduces glioma growth

    CRISPR-Cas knockout of miR21 reduces glioma growth 由 Lisa Nieland, Thomas S. van Solinge, Pike-See Cheah, Liza Morsett, Joseph El Khoury, Joseph I. Rissman, Benjamin P. Kleinstiver, Marike L. D. Broekman, Xandra O. Breakefield, Erik R. Abels

    出版 2022
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  17. 17
    Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads

    Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads 由 Kevin Leandro, David Rufino‐Ramos, Koen Breyne, Emilio Di Ianni, Sara Lopes, Rui Jorge Nobre, Benjamin P. Kleinstiver, Pedro R.L. Perdigão, Xandra O. Breakefield, Luís Pereira de Almeida

    出版 2024
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  18. 18
    Activities and specificities of <scp>CRISPR</scp>/Cas9 and Cas12a nucleases for targeted mutagenesis in maize

    Activities and specificities of <scp>CRISPR</scp>/Cas9 and Cas12a nucleases for targeted mutagenesis in maize 由 Keunsub Lee, Yingxiao Zhang, Benjamin P. Kleinstiver, Jimmy A. Guo, Martin J. Aryee, Jonah Miller, Aimee A. Malzahn, Scott Zarecor, Carolyn J. Lawrence‐Dill, J. Keith Joung, Yiping Qi, Kan Wang

    出版 2018
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  19. 19
    Discovery of widespread type I and type V CRISPR-Cas inhibitors

    Discovery of widespread type I and type V CRISPR-Cas inhibitors 由 Nicole D. Marino, Jenny Y. Zhang, Adair L. Borges, Alexander A. Sousa, Lina M. León, Benjamin J. Rauch, Russell T. Walton, Joel Berry, J. Keith Joung, Benjamin P. Kleinstiver, Joseph Bondy‐Denomy

    出版 2018
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  20. 20
    Precise DNA cleavage using CRISPR-SpRYgests

    Precise DNA cleavage using CRISPR-SpRYgests 由 Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Jiecong Lin, Linyuan Ma, Russell T. Walton, Luca Pinello, G. Brett Robb, Benjamin P. Kleinstiver

    出版 2022
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