Search Results - Benjamin P. Kleinstiver

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  1. 1
    Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

    Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants by Russell T. Walton, Kathleen A. Christie, Madelynn N. Whittaker, Benjamin P. Kleinstiver

    Published 2020
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  2. 2
    Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA

    Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA by Russell T. Walton, Jonathan Y. Hsu, J. Keith Joung, Benjamin P. Kleinstiver

    Published 2021
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  3. 3
    731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects

    731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects by Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew, Shengdar Q. Tsai, Nathalie T. Nguyen, J. Keith Joung

    Published 2016
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  4. 4
    Monomeric site-specific nucleases for genome editing

    Monomeric site-specific nucleases for genome editing by Benjamin P. Kleinstiver, Jason M. Wolfs, Tomasz Kolaczyk, Alanna K. Roberts, Sherry X. Hu, David R. Edgell

    Published 2012
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  5. 5
    High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

    High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects by Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew, Shengdar Q. Tsai, Nathalie T. Nguyen, Zongli Zheng, J. Keith Joung

    Published 2016
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  6. 6
    Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer

    Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer by Caroline Mahendra, Kathleen A. Christie, Beatriz A. Osuna, Rafael Pinilla‐Redondo, Benjamin P. Kleinstiver, Joseph Bondy‐Denomy

    Published 2020
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  7. 7
    Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

    Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells by Florian Wünnemann, Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P. Kleinstiver, Guillaume Lettre

    Published 2023
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  8. 8
    Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

    Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition by Benjamin P. Kleinstiver, Michelle S. Prew, Shengdar Q. Tsai, Nathalie T. Nguyen, Ved V. Topkar, Zongli Zheng, J. Keith Joung

    Published 2015
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  9. 9
    Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

    Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases by Joana Ferreira da Silva, Connor J. Tou, Emily M. King, Madeline L. Eller, Linyuan Ma, David Rufino‐Ramos, Benjamin P. Kleinstiver

    Published 2023
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  10. 10
    Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors

    Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors by Y. Esther Tak, Benjamin P. Kleinstiver, James K. Nuñez, Jonathan Y. Hsu, Joy E. Horng, Jingyi Gong, Jonathan S. Weissman, J. Keith Joung

    Published 2017
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  11. 11
    Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa

    Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa by Pingjuan Li, Benjamin P. Kleinstiver, Mihoko Leon, Michelle S. Prew, Daniel Navarro-Gomez, Scott H. Greenwald, Eric A. Pierce, J. Keith Joung, Qin Liu

    Published 2018
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  12. 12
    Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes

    Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes by Beatriz A. Osuna, Shweta Karambelkar, Caroline Mahendra, Kathleen A. Christie, Bianca Garcı́a, Alan R. Davidson, Benjamin P. Kleinstiver, Samuel Kilcher, Joseph Bondy‐Denomy

    Published 2020
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  13. 13
    Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

    Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells by Benjamin P. Kleinstiver, Shengdar Q. Tsai, Michelle S. Prew, Nathalie T. Nguyen, Moira M. Welch, Jose M. Lopez, Zachary R. McCaw, Martin J. Aryee, J. Keith Joung

    Published 2016
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  14. 14
    Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

    Enhanced proofreading governs CRISPR–Cas9 targeting accuracy by Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Alexander A. Sousa, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yıldız, Jennifer A. Doudna

    Published 2017
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  15. 15
    Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs

    Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs by Jennifer Listgarten, Michael M. Weinstein, Benjamin P. Kleinstiver, Alexander A. Sousa, J. Keith Joung, Jake Crawford, Kevin Gao, Luong Hoang, Melih Elibol, John G. Doench, Nicolò Fusi

    Published 2018
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  16. 16
    CRISPR-Cas knockout of miR21 reduces glioma growth

    CRISPR-Cas knockout of miR21 reduces glioma growth by Lisa Nieland, Thomas S. van Solinge, Pike-See Cheah, Liza Morsett, Joseph El Khoury, Joseph I. Rissman, Benjamin P. Kleinstiver, Marike L. D. Broekman, Xandra O. Breakefield, Erik R. Abels

    Published 2022
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  17. 17
    Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads

    Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads by Kevin Leandro, David Rufino‐Ramos, Koen Breyne, Emilio Di Ianni, Sara Lopes, Rui Jorge Nobre, Benjamin P. Kleinstiver, Pedro R.L. Perdigão, Xandra O. Breakefield, Luís Pereira de Almeida

    Published 2024
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  18. 18
    Activities and specificities of <scp>CRISPR</scp>/Cas9 and Cas12a nucleases for targeted mutagenesis in maize

    Activities and specificities of <scp>CRISPR</scp>/Cas9 and Cas12a nucleases for targeted mutagenesis in maize by Keunsub Lee, Yingxiao Zhang, Benjamin P. Kleinstiver, Jimmy A. Guo, Martin J. Aryee, Jonah Miller, Aimee A. Malzahn, Scott Zarecor, Carolyn J. Lawrence‐Dill, J. Keith Joung, Yiping Qi, Kan Wang

    Published 2018
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  19. 19
    Discovery of widespread type I and type V CRISPR-Cas inhibitors

    Discovery of widespread type I and type V CRISPR-Cas inhibitors by Nicole D. Marino, Jenny Y. Zhang, Adair L. Borges, Alexander A. Sousa, Lina M. León, Benjamin J. Rauch, Russell T. Walton, Joel Berry, J. Keith Joung, Benjamin P. Kleinstiver, Joseph Bondy‐Denomy

    Published 2018
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  20. 20
    Precise DNA cleavage using CRISPR-SpRYgests

    Precise DNA cleavage using CRISPR-SpRYgests by Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Jiecong Lin, Linyuan Ma, Russell T. Walton, Luca Pinello, G. Brett Robb, Benjamin P. Kleinstiver

    Published 2022
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